On this page, we provide information for those curious to learn more about the well-being of animals in science, as well as tools for scientists looking to take their own research Beyond3Rs.

The 3Rs of animal research were proposed by Russel and Burch in 1959. These ideas lay the groundwork for humane use of animals in research, but modern animal well-being science is expanding far beyond the scope of this framework. Click below to learn more about the original principles and how to go Beyond3Rs.

How to Go Beyond3Rs

Embracing Variability

Harmonizing animal and human research, spontaneous disease models, and biomarkers

Housing and Husbandry

Improving enclosures, enrichment, handling, nutrition, and other husbandry practices

Reproducibility and Translation

Experimental design, animal-to-human translation, and "the science of doing science"