The 3Rs of animal research were proposed by Russel and Burch in 1959. These principles provide a fundamental framework for humane animal use, but modern animal well-being science has expanded beyond the scope of the 3Rs.

Beyond3Rs is an initiative from the Department of Comparative Medicine at Stanford University, a world leading institution for research and education on laboratory animal well-being. We are a collaborative body of animal well-being researchers, veterinarians, and biomedical scientists.

We believe that “Good well-being is good science,” with an understanding that achieving this vision requires going Beyond3Rs.

Values, Vision, Mission

Our Values

  • We believe that animal research is necessary, and at the same time, that working with animals is a privilege, not a right.
  • We believe that the 3Rs are necessary principles, but we can always look for opportunities to further improve laboratory animal well-being.
  • We believe that animal work should be designed to maximize the likelihood of benefits to humans and other animals, to minimize harms,
    and to maximize animal well-being.

Our Vision

We imagine a world where animal research benefits everybody — not only all humans, but other animals, too — and where the well-being of research animals is seen as the most central piece of successful biomedical research.

Our Mission

  • To build on Stanford's reputation as an optimal place to research or learn about laboratory animal well-being
  • To pioneer a new discipline of translational research in laboratory animal well-being
  • To promote research, education, outreach, theory and practice in laboratory animal well-being

How to Go Beyond3Rs

Embracing Variability

Harmonizing animal and human research, spontaneous disease models, and biomarkers

Housing and Husbandry

Improving enclosures, enrichment, handling, nutrition, and other husbandry practices

Reproducibility and Translation

Experimental design, animal-to-human translation, and "the science of doing science"


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