Recent Publications

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Lee, S., Vander Roest, A., Blair, C., Kao, K., Bremner, S., Childers, M., Pathak, D., Heinrich, P., Lee, D., Chirikian, O., Mohran, S., Roberts, B., Smith, J., Jahng, J., Paik, D., Wu, J., Gunawardane, R., Ruppel, K., Mack, D., Pruitt, B., Regnier, M., Wu, S., Spudich, J., and Bernstein, D. Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration, PNAS 2024 April 29 121 (19) e2318413121 PMID: 2318413121

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Ranjbarvaziri S, Fajardo G, Zhao M, Vaziri S, Ruppel K, Spudich J, Contrepois K, Woo J, Snyder M, Bernstein D. mitochondrial function and metabolism? Circulation Oct 21, 2021. PMID: 34672721

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Vander Roest AS, Liu C, Morck MM, Kooiker KB, Jung G, Song D, Dawood A. Jhingran A, Pardon G, Ranjbarvaziri S, Fajardo G, Zhao M, Campbell KS, Pruitt BL, Spudich J, Ruppel K, Bernstein D. Hypertrophic cardiomyopathy ß-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state. PNAS 2021 Jun 15;118(24), 2021. PMID: 34117120

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Magdy T, Jouni M, Kuo H-H, Weddle C, Lyra-Leite D, Fonoudi H, Romero-Tejada M, Gharib M, Javed H, Fajardo G, Carleton B, Bernstein D, Burridge P. Identification of Drug Transporter Genomic Variants and Inhibitors that Protect Against Doxorubicin-Induced Cardiotoxicity. Cell Stem Cell. 2021 Sep 14, 2021. PMID: 34525346

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Raftrey B, Williams I, Rios Coronado, PE, Chang AH, Zhao M, Roth R, Racelis R, D’Amato G, Phansalkar R, Gonzalez KM, Zhang Y, Bernstein D, Red-Horse K, Dach1 extends artery networks and protects against cardiac injury. Circ .Res. 2021 Sep 17;129(7):702-716. PMID: 34383559

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Jiang Z, Magdy T, Burmeister BT, Kuo H-H, Jung G, Romero-Tejeda M, Schuldt AJT, Egecioglu D, Chen C, Zhao M, Ntziachristos P, Sanz-Clemente A, Horiuchi D, Ross CJD, Carleton BC, Bernstein D, Burridge PW. Validation of a GWAS-identified variant in RARG as a risk predictor of doxorubicin–induced cardiotoxicity using patient-derived hiPSC-CMs. Cell Stem Cell Sep., 2021. PMID: 34525346. *Drs. Bernstein and Burridge are co-corresponding authors.

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JHV Hwang, N Sandeep, RV Nair, DQ Hu, M Zhao, IS Lan, G Fajardo, SJ Matkovich, D Bernstein, S Reddy. Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload-induced Right Ventricular Failure. JAHA, 10:e017835, 2021. PMID 33522250.

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Voltarelli VA, Coronado M, Fernandez LG, Campos JC, Jannig PR, Ferreira JCB, Fajardo G, Brum PC, Bernstein D. β2-adrenergic signaling modulates mitochondrial function and morphology in skeletal muscle in response to aerobic exercise. Cells 10:146, 2021.PMID: 33450889.

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Edwards J, Brandimarto JA, Dong-Qing H, Jeong S, Yucel N, Li L, Bedi K, Wada S, Murashige D, Hwang HT, Zhao M, Margulies K, Bernstein D, Reddy S, Arany Z. Noncanonical WNT activation in human right ventricular heart failure. Frontiers in Cardiovasc. Med. 7:582407, 2020. PMID: 33134326.

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Hwang HV, Sandeep N, Paige S, Vaziri S, Hu DQ, Zhao M, Lan IS, Coronado M, Kooiker KB, Fajardo G, Bernstein D, Reddy S. 4HNE Impairs Myocardial Bioenergetics in Congenital Heart Disease-induced Right Ventricular Failure. Circulation 142:1667-1683, 2020. PMID: 32806952.

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Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM. β-Cardiac Myosin Hypertrophic Cardiomyopathy Mutations Release Sequestered Heads and Increase Enzymatic Activity. Nature Commun., 10: 2685, 2019. PMID: 31213605.

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Haileselassie B, Mukherjee R, Joshi AU, Napier BA, Massis LM, Ostberg NP, Queliconi BB, Monack D, Bernstein D, Mochly-Rosen D. Drp1/Fis1 Interaction Mediates Mitochondrial Dysfunction in Septic Cardiomyopathy. J. Mol. Cell. Cardiol. 130: 160-169, 2019. PMID: 30981733.

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Coronado M, Zhao M, Fajardo G, Jung G, Gottlieb R, Bernstein D. Physiological mitochondrial fragmentation is a cardiac adaptation to increased demand. Circulation Research 122: 282-295, 2018. PMID: 29233845.

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Bock MJ, Pahl E, Rusconi PG, Boyle GJ, Parent JJ, Twist CJ, Kirklin JK, Pruitt E, Bernstein D. Cancer recurrence and mortality after pediatric heart transplantation for anthracycline cardiomyopathy. Pediatr. Transpl Aug;21(5), 2017. PMID: 28378408.

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Reddy S, Hu D-Q, Zhao M, Blay E, Sandeep N, Ong S-G, Jung G, Kooiker KB, Coronado M, Fajardo G, Bernstein D. miR-21 is associated with fibrosis and right ventricular failure. JCI Insight 2(9): e91625, 2017. PMID 5414555.

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Adhikari AS, Kooiker KB, Sarkar SS, LuiC, Bernstein D, Spudich JA, Ruppel KM. Early onset hypertrophic cardiomyopathy mutations significantly increase the velocity, force, and actin-activated ATPase activity of human β-cardiac myosin. Cell Rep. 17:2857-2864, 2016. PMID: 27974200.

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Kodo K, Ong S-G, Jahanbani F, Termglinchan VT, Rahatloo KI, Ebert A, Shulka R, Abilez O, Churko J, Karakikes I, Jung G, Synder MP, *Bernstein D, *Wu JC. iPSC-derived cardiomyocytes reveal abnormal TGFβ signaling in left ventricular non-compaction cardiomyopathy. Nature Cell Biology 18: 1031-42, 2016. PMID: 27642787. * Drs. Bernstein and Wu are co-corresponding authors.

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Gottlieb R, Bernstein D. Mitochondrial Remodeling: Rearranging, recycling, and reprogramming. Cell Calcium 60:88-101, 2016. PMID: 27130902.

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Burridge PW, Matsa E, Ebert AD, Wu H, Fuga Y, Wilson KD, Churko JM, Mordwinkin NN, Ong S-G, Chang AC, Metzler SA, Simmons CS, Knowles JW, Telli ML, Witteles RM, Blau HM, Altman RB, Bernstein D, Gold JD, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to Doxorubicin-Induced Cardiotoxicity. Nature Medicine 22:547-56, 2016. PMID: 27089514.

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Jung G, Fajardo G, Ribeiro AJS, Bezold K, Coronado M, Zhao M, Hu, D-Q, Reddy S, Kodo K, Sriram K, Insel PA, Pruitt BL, Wu J, Bernstein D. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. FASEB J. 30:1464-79, 2016. PMID: 26675706.

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Aminkeng F, Visscher H, Rassekh SR, Bhavsar AP, Brunham LR, Weissman CR, Lee JW, Caron HN, van Dalen EC, Kremer LC, can der Pal HJ, Rider MJ, Bernstein D, Ross CJD, Carleton BC, Hayden MR. A Coding Variant in RARG Confers Susceptibility to Anthracycline-Induced Cardiotoxicity in Childhood Cancer. Nature Genetics 47(9):1079-84, 2015. PMID: 26237429.

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Reddy S, Zhao MM, Hu D-Q, Fajardo G, Katznelson E, Punn R, Spin JM, Chan FP, Bernstein D. Physiologic and molecular characterization of a murine model of right ventricular volume overload. Amer. J. Physiol 304:H1314-27, 2013. PMID 23504182.

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Rajagopalan V, Zhao M, Reddy S, Fajardo G, Wang X, Dewey S, Gomes AV, Bernstein D. Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Amer J. Physiol 305: H551-62, 2013. PMID 23729213.

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Reddy S, Zhao MM, Fajardo G, Hu S, Wu J, Bernstein D. Dynamic microRNA expression during the transition from RV hypertrophy to failure. Physiol. Genomics 44: 562-75, 2012. PMID 22454450