Beckman Research Highlights
Q2 2026
The Jarosz lab's recent publication describes how prions can act as molecular dials that yeast use to speed up their own mutation rate under stress. This "mutagenesis switch" helps yeast rapidly adapt to environmental challenges, and may represent a new target for antifungal drug development.
Q1 2026
Mechanical Forces Regulate the Composition and Fate of Stalled Nascent Chains
Brandman Lab
Khan D, Vinayak AA, Sitron CS, Brandman O. Mechanical forces regulate the composition and fate of stalled nascent chains. Mol Cell. 2026 Jan 8;86(1):97-113.e4. PMID: 41475347.
Defining the Rules of Protein Interactions
Garcia Lab
Yang A, Jiang H, Jude KM, Akpinaroglu D, Allenspach S, Li AJ, Bowden J, Perez CP, Liu L, Huang PS, Kortemme T, Listgarten J, Garcia KC. Structural ontogeny of protein-protein interactions. Science. 2026 Feb 12;391(6786):eadx6931. PMID: 41678610.
DUO‑1 Safeguards Meiotic Chromosome Architecture during Meiosis
Villeneuve Lab
Strand LG, Choi CP, McCoy S, Nsamba ET, Silva N, Villeneuve AM. Active maintenance of meiosis-specific chromosome structures in Caenorhabditis elegans by the deubiquitinase DUO-1. Proc Natl Acad Sci USA. 2026 Mar 24;123(12):e2532671123. PMID: 41838919.
Visualizing Cellular Recycling
CSIF / Abu-Remaileh Lab
Ghoochani A, Heiby JC, Rawat ES, Medoh UN, Di Fraia D, Dong W, Gastou M, Rastogi M, Hernandez V, Nyame K, Laqtom NN, Durso W, Valkova C, Isakova A, Kaether C, Wernig M, Gomez-Ospina N, Franke C, Ori A, Abu-Remaileh M. Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder. Cell. 2026 Feb 5;189(3):765-782.e31. PMID: 41576950.