Beckman Publications

 

Explore the latest scientific publications from the Beckman Center.

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Q3 2026

August 2026

 
  • Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology Belinda Wang, Rasika Vartak, Kelsey M. Hennick, Yefim Zaltsman, Zun Zar Chi Naing, Benjamin J. Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela Lasser, Yuan Zhou, Justin McKetney, Keelan Z. Guiley, Paweł Gniewek, Úna Chan, Naufa Amirani, Owen Griffiths, Nishant Chadha, Reshmi Tognatta, Merve Çakır, Martin Gordon, Prachi Khare, Sam Drake, Vanessa Drury, David F. Burke, Silvano Gonzalez, Sahar Alkhairy, Reuben Thomas, Stephanie Lam, Montana Morris, Ethel Bader, Mélanie Dos Santos, Anastassia V. Komarova, Maxwell Bennett, Craig L. Ennis, Octavio Castillo, Yvonne Lim, Robert Martin, Meghan Seyler, Tierney Baum, Rebecca Krasnoff, George Wang, Sagnik Middya, Sheng Wang, P Pham, Juan Arbelaez, Dexter Pratt, Sofia Bali, Shivali Chag, Julia Kaye, Nadir Mahmood, Lee Spraggon, Thomas Rolland, Shawn L. Hervey‐Jumper, James S. Fraser, Thomas Bourgeron, Steven Finkbeiner, Caroline Demeret, Danielle L. Swaney, Sourav Bandyopadhyay, Trey Ideker, Pedro Beltrão, Helen Rankin Willsey, Ruth Hüttenhain, Kirsten Obernier, Tomasz J. Nowakowski, Matthew W. State, A. Jeremy Willsey, Nevan J. Krogan. Science. 2026-08-27;393(6814):eady4523-eady4523. doi: 10.1126/science.ady4523. PMID: 42658940
 
  • De novo design of RNA pseudoknots with deep learning Jill Townley, Wipapat Kladwang, David Baker, Hamish M Blair, Christian Choe, Gina El Nesr, Andrew Favor, Eli Fisker, Daniel B. Haack, Shujun He, J. Hingey, R J Huang, Po‐Ssu Huang, Chaitanya K Joshi, Thomas G. Karagianes, Andrew Kubaney, Pietro Lio, Adamo Mancino, Jonathan Romano, Boris Rudolfs, Nicholas Spellmon, Navtej Toor, Jigyasa Verma, Vivian Wu, Zhiheng Yu, Eterna Participants, Rhiju Das. Science. 2026-08-27;393(6814):931-937. doi: 10.1126/science.aeg6829. PMID: 42658941
 
 
 
  • “Home” Lawrence Steinman. Neurology Neuroimmunology & Neuroinflammation. 2026-08-24;13(5):e200625-e200625. doi: 10.1212/nxi.0000000000200625. PMID: 42636413
 
  • Lipoproteins modulate the uptake and biological function of cationic cell-penetrating peptides across the animal lineage Sovanny R. Taylor, Temilade V. Oluwasesin, Muthu Raj Salaikumaran, Borna Novak, Adam Briner, Roshan Ailani, Pilar I. Andrade, Paulo L. Onuchic, Olivia M. S. Carmo, Garam Kım, Jacob A. Blum, Mason Galliver, Catherine Stuart, Nicolás Méndez, Vedant Patel, Guo-Teng Liang, Ronan O’Connell, Mohammad Majharul Islam, Zeinab Kashaniasl, María José Villar, Yingqiong Cao, Xi‐Lei Zeng, Lucas Porta, Haoyun Yang, Gabe Hohensee, Misha Kavalur, Rachel N. Arey, Sarah N. Blutt, Ewan K.S. McRae, Radbod Darabi, Lilei Zhang, Kathryn Jones, Simon G. Pfisterer, Chad W. Johnston, Jeroen Pollet, Mirian A. F. Hayashi, Aaron D. Gitler, Hyun Kyoung Lee, Alex S. Holehouse, Steven J. Ludtke, Steven Boeynaems. bioRxiv (Cold Spring Harbor Laboratory). 2026-08-24. doi: 10.64898/2026.08.23.746575.
 
  • RNA delivery to the corneal endothelium using charge-altering releasable transporters Sean K. Wang, Sean K. Wang, Zhijian Li, Sahil Shah, Quincy A. Edwards, Richard Bouffard, Elizabeth S. Hines, Joel A. Imventarza, Sven Korte, Matthew S. Lawrence, Euisun Song, Essam Helmy, Laura Amaya, Nae-Won Kang, David Myung, Miao-Chih Tsai, William J. Greenleaf, Robert M. Waymouth, Sui Wang, Sui Wang, Paul A. Wender, Howard Y. Chang. Science Advances. 2026-08-21;12(34):eady8161-eady8161. doi: 10.1126/sciadv.ady8161. PMID: 42627922
 
 
 
 
 
  • Structural mechanism governing the directionality of bridge recombination Masahiro Hiraizumi, Januka S. Athukoralage, Nicholas T. Perry, Eisuke Tsujimoto, Nami Shiojiri, Naoto Nagahata, Lauren Lee, Gwanggyu Sun, Matthew G. Durrant, Sita S. Chandrasekaran, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu. Nature. 2026-08-12. doi: 10.1038/s41586-026-10903-y. PMID: 42587149
 
 
 
  • Engulfment by brain macrophages in a short-lived vertebrate Rahul Nagvekar, Angela N. Pogson, Prateek R Kalakuntla, Helena J Barr, Azalia M Martínez Jaimes, SV Perry, Emma K. Costa, Jingxun Chen, Felix Boos, Paloma Navarro Negredo, Luise A. Seeker, James B. Jaggard, Rogelio Barajas, Philippe Mourrain, Param Priya Singh, Stephen R. Quake, Tony Wyss‐Coray, Kristy Red‐Horse, Beth Stevens, Bo Wang, Claire N. Bedbrook, Ravi D. Nath, Anne Brunet. eLife. 2026-08-04. doi: 10.7554/elife.112503.
 
 
 
 
  • Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols-Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D. Greicius. Annals of Neurology. 2026-08-03. doi: 10.1002/ana.78303. PMID: 42548036
 
  • Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome Yuan Xu, Hailey Loucks, Julian Menendez, Fedor Ryabov, Julian Lucas, Monika Čechová, Luke Morina, Emily Xu, Danilo Dubocanin, Cy Chittenden, Mobin Asri, Ivo Violich, Christian Ortiz, Joshua M.V. Gardner, Todd Hillaker, Sara O'Rourke, Brandy McNulty, Tamara Potapova, Matthew W. Mitchell, Jacob P. Schwartz, Aaron F. Straight, Jennifer L. Gerton, Winston Timp, Ivan A. Alexandrov, Nicolas Altemose, Karen H. Miga. Cell Genomics. 2026-08-01;6(8):101324-101324. doi: 10.1016/j.xgen.2026.101324. PMID: 42561950
 
  • Mapping enhancer–gene regulatory interactions from single-cell data Maya U. Sheth, Wei‐Lin Qiu, X. Rosa, Andreas R. Gschwind, Evelyn Jagoda, Anthony S. Tan, James Galante, Judhajeet Ray, Dulguun Amgalan, Hjörleifur Einarsson, Bram L. Gorissen, Danilo Dubocanin, Christopher S. McGinnis, Jacob Huang, Glen Munson, Kayla Brand, Ansuman T. Satpathy, Thouis R. Jones, Lars M. Steinmetz, Anshul Kundaje, Berk Ustun, J Engreitz, Robin Andersson. Nature Genetics. 2026-08-01;58(8):1941-1952. doi: 10.1038/s41588-026-02695-8. PMID: 42547575
 
 
 
  • Predicting cellular responses to perturbation across diverse contexts with State Abhinav Adduri, Dhruv Gautam, Beatrice Bevilacqua, Mohsen Naghipourfar, Alishba Imran, Rohan Shah, Noam Teyssier, Rishi Verma, Christopher Carpenter, Basak Eraslan, Francis Chalissery, Rajesh Ilango, Vishvak Subramanyam, Chiara Ricci-Tam, Sanjay Nagaraj, Aidan Winters, Mingze Dong, Stefanie Fellinger, Adam Krejčí, Tilmann Bürckstümmer, Sravya Tirukkovular, Jeremy Sullivan, Brian S. Plosky, Nicholas D. Youngblut, Jure Leskovec, Luke A. Gilbert, Silvana Konermann, Patrick D. Hsu, Alexander Dobin, Dave P. Burke, Hani Goodarzi, Yusuf Roohani. Cell. 2026-08-01. doi: 10.1016/j.cell.2026.07.052. PMID: 42673963
 
  • Virtual Cell Challenge 2026: Benchmarking zero-shot generalization across cellular contexts Abhinav Adduri, Dave Burke, Joseph Caputo, Paul Datlinger, Alexander Dobin, Basak Eraslan, Luke Gilbert, Ben Hsu, Ben Hsu, Tony Hua, Julia Kazaks, Silvana Konermann, Dara Leto, Reshma Mehta, Usman Muzaffar, Brian Plosky, Chiara Ricci-Tam, Rachel Senturia, Jeremy Sullivan, Michael Teng, Sadie VanHorn, Megan van Overbeek, Alden Woodrow, Usha Adhikari, Will Agnew-Svoboda, Valeria Aizen, Dana Al-Azzeh, Daniel Alameda Serrano, William Allen, Alexander Atamian, Inna Averbukh, Jerika Barron, Beatrice Bevilacqua, Harry Bevir, Steven Boggess, Paul Bunk, Maria Erendira Calleja Cervantes, Christopher Carpenter, Yi-Chen Chih, Shawn Chizari, Cyntia Del Valle Gomez, Xiaolong Dong, Miles Duncan, Kevin Feng, Carmen Gallardo, Gabriel Grenot, Jesse Holt, Parsa Idehpour, Malvenderjit Jagjit Singh, Emiliano Josue Hergenreder, Aarushi Kalaimani, Trinh Lam, David Lara Astiaso, Nianzhen Li, Victor Li, Jonathan Lyda, Gabriella Martyn, Satoru Miura, Sanmati Nagesh, Harris Nami, Alexander Nevue, Charlene Pan, Khushali Patel, Akshaya Rajan, Kheerthivasan Ramachandran, Ninad Ranadive, Sneha Rao, Lorena Saavedra, Nerea Santana Gonzalez, Kristen Seim, Tulsi Solanki, Jin Wen Tan, Ipek Tasan, Ed Tuan, Po-Yuan Tung, Rishi Verma, Tushita Wadhawan, Flora Yi, Nick Youngblut, Jamie Zaikov, Hani Goodarzi. Cell. 2026-08-01. doi: 10.1016/j.cell.2026.08.004. PMID: 42648290
 

July 2026

 
 
 
 
 
 
  • Antimalarial cytoskeletal targeting with broad apicomplexan activity Darshan V. Trivedi, Anastasia Karabina, Tiantian Jiang, Daisy Chen, Nimisha Mittal, Tonnie Huijs, Rianne van der Laak, Jin H. Jeon, Tomas Yeo, Dihia Moussaoui, James P. Robblee, Marianna Akey, Matthew Freese, Lorraine Fuller, Gustave Bergnes, Alice Racca, Heba Wander, Seongwon Jung, Stephanie Ouchida, Paul V. Ruijgrok, Dan Song, Annamma Spudich, Kathleen M. Ruppel, Suman Nag, Christoph Mueller‐Dieckmann, Jeremy N. Burrows, Benoı̂t Laleu, Rafael V. C. Guido, Anna Caroline Campos Aguiar, Dhélio B. Pereira, Sergio Wittlin, Partha Mukherjee, Arnish Chakraborty, Samuel E. Aggrey, Julien Robert‐Paganin, K M Trybus, L. David Sibley, Anne Houdusse, David A. Fidock, Koen J. Dechering, Elizabeth A. Winzeler, James A. Spudich. Proceedings of the National Academy of Sciences. 2026-07-24;123(30):e2608709123-e2608709123. doi: 10.1073/pnas.2608709123. PMID: 42497201
 
 
  • Single-cell chromatin state transitions during epigenetic memory formation Taihei Fujimori, Abby R. Thurm, Simon Gaudin, Carolina Rios-Martinez, Benjamin R. Doughty, Michaela M. Hinks, Joydeb Sinha, Derek Le, Antonina Hafner, William J. Greenleaf, Alistair N. Boettiger, Lacramioara Bintu. Science Advances. 2026-07-23;12(30):eaeb0060-eaeb0060. doi: 10.1126/sciadv.aeb0060. PMID: 42490451
 
 
  • Damaging RBM20 E-rich domain variants are not rescued by gene replacement Fang Bai, K.Y. Chua, D. Li, Анна Кіріллова, Sunil Yadav, David Staudt, Yuta Yamamoto, Hannah N. De Jong, Linda Helena Müller, Kai Fenzl, Non Rungaramsin, Yong Huang, Chloe M. Reuter, Xicheng Zhang, Vikki A. Krysov, Joyce Njoroge, Brendan J. Floyd, Neal K. Lakdawala, Cynthia A. James, Douglas Cannie, Perry Elliott, Luisa Mestroni, Anjali Owens, Marco Merlo, Andrew D. Krahn, Chad Mao, Diane Fatkin, Vasanth Vedantham, C. Anwar A. Chahal, Adam Helms, Joseph C. Wu, Calum A. MacRae, Michael Gotthardt, Dan M. Roden, Frederick P. Roth, Euan A. Ashley, Benjamin Meder, Brett M. Kroncke, Daniel Tabet, Atina Cote, Lars M. Steinmetz, Andrew M. Glazer, Mark Mercola, Victoria N. Parikh. bioRxiv (Cold Spring Harbor Laboratory). 2026-07-20. doi: 10.64898/2026.07.13.738343. PMID: 42523282
 
 
  • Meeting report – CellExIt#1, the first international symposium on cell extrusion Naoka Shiratsuchi, Yasuyuki Fujita, Simon de Beco, Cécile Daubech, Benoît Ladoux, Aline Grata, Romain Levayer, Emile Magny, Lucy Erin O’Brien, Rashmi Priya, Saranne J. Mitchell, Jody Rosenblatt, Jean-François Rupprecht, Lieke Stockmann, Jakub Sedzinski, Léa Roquin, Magali Suzanne, Yusuke Toyama, Marija Matekcic, Xavier Trepat, Sabrina Vinzens, Sara A. Wickström, Angela K.O. Lwin, Alpha S. Yap. Journal of Cell Science. 2026-07-15;139(14). doi: 10.1242/jcs.265128. PMID: 42504880
 
 
 
 
  • Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy Laura Sen-Martín, Ángel Fernández‐Trasancos, Miguel López-Unzu, Agata Bak, Magdalena Zafra-Castellano, Rajiven Srikantharajah, Divya Pathak, Annika Klotz, Michel N. Kuehn, Alessia Ferrarini, V. Labrador, David Sánchez-Ortiz, María Rosaria Pricolo, Natalia Vicente, Diana Velázquez-Carreras, Lucía Sánchez, Jon Sicilia, José Ángel Nicolás-Ávila, María Sánchez-Díaz, Saskia Schlossarek, Lorena Cussó, Manuel Desco, María Villalba-Orero, Gabriela Guzmán, Enrique Calvo, Roberto Barriales‐Villa, Jesús Vázquez, Fátima Sánchez‐Cabo, Andrés Hidalgo, Pieter P. de Tombe, Lucie Carrier, James A. Spudich, Kathleen M. Ruppel, Florian Weinberger, Olivier Cazorla, Anthony L. Hessel, Jorge Alegre‐Cebollada. Nature Cardiovascular Research. 2026-07-07;5(7):638-657. doi: 10.1038/s44161-026-00833-3. PMID: 42414613
 
  • Remembering George Smoot John Berliner, T. Broadhurst, Martin Bucher, R. N. Cahn, Jorge L. Cervantes–Cota, Steven Chu, Nóra Csiszár, Razieh Emami, Leo Fung, Ken Ganga, Alison Goldwyn, Bill Green, Dhiraj Kumar Hazra, Paula Keeney, Albert Wai Kit Lau, Sean Siyang Li, Eric Linder, Charley Lineweaver, Tao Liu, Omar López-Cruz, Philip Lubin, Kam-Biu Luk, John Mather, Saul Perlmutter, Federico Piazza, Barbara Rittner, Uros Seljak, Mehdi Shafiee, Tony Spadafora, Graciela Tiburcio Pintos, Henry Tye, Ann Whetstone, Alex Zhavoronkov. HAL (Le Centre pour la Communication Scientifique Directe). 2026-07-06.
 
  • Towards the construction of a virtual yeast Liujia Qian, Zizhuo Zhou, Peijie Zhou, Zhen Dong, Xi Zhang, Zhenwu Dai, Zhangyang Gao, Siqi Sun, Kevin Roy, Shuaiyao Wang, Nicola Zamboni, Charles Boone, Michael Costanzo, Li J, Gianni Liti, Jia‐Xing Yue, Markus Ralser, Evan Williams, Mattia Zampieri, Heng Jiang, Tailin Wu, Yuxing Wang, Feiran Li, Joseph Schacherer, Rui Sun, Zhaoxing Li, Yaming Deng, Yi Chen, Zhiping Xie, Huiqiang Lou, Xiaowen Wang, Linhai Xie, Han Wen, Liangyi Chen, Kai Lei, George Rosenberger, Xue Cai, Yingrui Wang, Qi Xiao, Huaizong Shen, Gaowen Liu, Лей Ма, Brenda Andrews, Hui Lü, Kiryl D. Piatkevich, Yi Zhu, Lei Bai, Yizhi Cai, Yuping Chen, E Weinan, Ge Gao, Fuchu He, Luonan Chen, Stan Z. Li, Hongwu Ma, Liang Qiao, Lars M. Steinmetz, 汤雷翰, Tang Tang, Xi Zhang, Jing Yang, Yifan Yang, Kaicheng Yu, Jianyang Zeng, Yefeng Zheng, B D Zhou, Tiannan Guo. Nature. 2026-07-01;655(8121):59-70. doi: 10.1038/s41586-026-10574-9. PMID: 42387167
 
  • Harmonizing standards and resources for the medical genome Euan A. Ashley, Ash A. Alizadeh, Hanae Armitage, Ami S. Bhatt, Yair Blumenfeld, Andrew Carroll, R. Martin Chavez, Petros Giannikopoulos, Megan E. Grove, Meghan C. Halley, Kiran Khush, Niall J. Lennon, Samantha Maragh, Alexander Marson, Benedict Paten, Adam M. Phillippy, Matthew H. Porteus, Heidi L. Rehm, Bradley R. Ringeisen, Julia Salzman, Valérie Schneider, Fritz J. Sedlazeck, Lars M. Steinmetz, Fyodor D. Urnov, Stacia K. Wyman, Justin M. Zook, Lloyd B. Minor, Jennifer A. Doudna. Nature. 2026-07-01;655(8121):47-58. doi: 10.1038/s41586-026-10621-5. PMID: 42387168
 
 
 
 
 
 
  • A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death Meredith N Nix, Sai Gourisankar, Kevin J. Bowman, Sabin A. Nettles, H H Yang, Brendan G. Dwyer, Roman C. Sarott, Hind Abuzaid, Michael M. Martinez, Nick Phillips, Vincent Cabaud, Artur Hakobyan, Vahram Arakelov, Garik Petrosyan, Aram Davtyan, Yanlan Wang, Juste M. Simanauskaite, Bryan A. Romero, Hannah M. Jones, A. Krokhotin, Tara N. Lowensohn, Le Chen, Cara Low, Hannes Vogel, Mark M. Davis, Daniel Fernandez, Tinghu Zhang, Michael R. Green, Stephen M. Hinshaw, Nathanael S. Gray, Gerald R. Crabtree. Cell. 2026-07-01. doi: 10.1016/j.cell.2026.06.037. PMID: 42476129