Research Interests & Publications
Dr. Peter Bayley and his team are featured contributors in the Life Sciences Special Edition on Gulf War Illness State of the Science. Presenting research findings to support the accumulating evidence suggesting that Gulf War illness (GWI) is characterised by autonomic nervous system dysfunction (higher heart rate [HR], lower heart rate variability [HRV]).
Dr. Bayley's compared (i) whether HR and HRV improved among Veterans with GWI receiving either yoga or cognitive behavioural therapy (CBT) for pain; and (ii) whether baseline autonomic functioning predicted treatment-related pain outcomes across follow-up. Their results showed that Veterans who received CBT tended towards higher mean HR at end-of-treatment. Better autonomic function (lower mean HR, higher RMSSD/HF-HRV) at baseline predicted greater reductions in pain across follow-up, regardless of treatment group. Better baseline autonomic function (mid-range-to-high RMSSD/HF-HRV) also predicted greater pain reductions with yoga, while worse baseline autonomic function (higher mean HR, lower RMSSD/HF-HRV) predicted greater pain reductions with CBT.
This is the first study to suggest that among Veterans with GWI, HR may increase with CBT yet remain stable with yoga. Furthermore, HR and HRV moderated pain outcome across follow-up for yoga and CBT. Mean HR increased in Veterans with GWI receiving CBT yet remained stable with yoga. Furthermore, HR and HRV moderated pain outcome across follow-up for yoga and CBT.
- Study Highlights
- • Mean HR increased in Veterans with GWI receiving CBT yet remained stable with yoga.
- • Baseline HR and HRV predicted pain across follow-up regardless of treatment type.
- • CBT was more effective for pain in Veterans with higher HR and lower RMSSD/HF-HRV.
- • Yoga was more effective for pain in Veterans with higher baseline RMSSD and HF-HRV.
- • If replicated, HR and HRV may be used to select individualised GWI treatment.
VA Polytrauma Monthly Seminar
Dissemination of research findings on traumatic brain injury and related conditions, primarily among US Veterans.
Meditation as Trauma Therapy: Results from a randomized clinical trial comparing a Breathing-Based Meditation to Cognitive Processing Therapy for Treating PTSD Symptoms in Military Veterans
Dr. Peter Bayley presents on the growing interest in the use of complementary and integrative health, including the use of meditation for treating PTSD. Breathing-based meditation is unique compared to other types of meditation as it involves a process that normally operates unconsciously but through training can be consciously controlled to rapidly impact emotion. One such breathing-based meditation technique known as Sudarshan Kriya Yoga (SKY) has previously shown some efficacy in treating PTSD.
However, no previous studies have compared SKY head-to-head with gold-standard trauma therapy. Results from a recent randomized controlled noninferiority trial demonstrating that SKY was statistically not inferior to standard treatment (Cognitive Processing Therapy) in reducing PTSD symptoms and depression. Findings are discussed in the context of a growing number of clinical trials showing that integrative health approaches are effective in treating PTSD.
Mathersul DC, Dixit K, Avery TJ, Schulz-Heik RJ, Zeitzer JM, Mahoney LA, Cho RH, Bayley PJ. Heart rate and heart rate variability as outcomes and longitudinal moderators of treatment for pain across follow-up in Veterans with Gulf War illness. Life Sciences. 2021 Jul 15;277:119604.
Zhang Y, Avery T, Vakhtin AA, Mathersul DC, Tranvinh E, Wintermark M, Massaband P, Ashford JW, Bayley PJ, Furst AJ. Brainstem atrophy in Gulf War Illness. Neurotoxicology. 2020 May;78:71-79. doi: 10.1016/j.neuro.2020.02.006. Epub 2020 Feb 17. PMID: 32081703.
Zhang Y, Vakhtin AA, Dietch J, Jennings JS, Yesavage JA, Clark JD, Bayley PJ, Ashford JW, Furst AJ. Brainstem damage is associated with poorer sleep quality and increased pain in gulf war illness veterans. Life Sci. 2021 Sep 1;280:119724. doi: 10.1016/j.lfs.2021.119724. Epub 2021 Jun 16. PMID: 34144059.
Avery, Tim & Schulz-Heik, R. & Friedman, Marcelle & Mahoney, Louise & Ahmed, Nabiha & Bayley, Peter. (2020). Clinical yoga program utilization in a large health care system. Psychological Services. 10.1037/ser0000420.
Zhuang, Liping & Wang, Jingyi & Xiong, Bingsen & Bian, Cheng & Hao, Lei & Bayley, Peter & Qin, Shaozheng. (2020). Rapid Neural Reorganization during Retrieval Practice Predicts Subsequent Long-term Retention and False Memory. 10.1101/2020.04.02.020321.
Journal of the American Geriatrics Society
Bayley PJ, Kong JY, Mendiondo M, Lazzeroni LC, Borson S, Buschke H, Dean M, Fillit H, Frank L, Schmitt FA, Peschin S, Finkel S, Austen M, Steinberg C, Ashford JW. Findings from the National Memory Screening Day program. Journal of the American Geriatrics Society. 63: 309-14. PMID 25643739 DOI: 10.1111/jgs.13234
Isaac L, Main KL, Soman S, Gotlib IH, Furst AJ, Kinoshita LM, Fairchild JK, Yesavage JA, Ashford JW, Bayley PJ, Adamson MM. The impact of depression on Veterans with PTSD and traumatic brain injury: a diffusion tensor imaging study. Biological Psychology.105: 20-8. PMID 25559772 DOI: 10.1016/j.biopsycho.2014.12.011
Medical Research Methodology
Bayley PJ, Kong JY, Helmer DA, Schneiderman A, Roselli LA, Rosse SM, Jackson JA, Baldwin J, Isaac L, Nolasco M, Blackman MR, Reinhard MJ, Ashford JW, Chapman JC. Challenges to be overcome using population-based sampling methods to recruit veterans for a study of post-traumatic stress disorder and traumatic brain injury. Bmc Medical Research Methodology. 14: 48. PMID 24713131 DOI: 10.1186/1471-2288-14-48
Journal of the Alzheimer's Association
Borson S, Frank L, Bayley PJ, Boustani M, Dean M, Lin PJ, McCarten JR, Morris JC, Salmon DP, Schmitt FA, Stefanacci RG, Mendiondo MS, Peschin S, Hall EJ, Fillit H, et al. Improving dementia care: the role of screening and detection of cognitive impairment. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 151-9.PMID 23375564 DOI: 10.1016/j.jalz.2012.08.008
Aviation, Space, and Environmental Medicine
International Journal of Behavioral Medicine
Hawkinson JE, Ross AJ, Parthasarathy S, Scott DJ, Laramee EA, Posecion LJ, Rekshan WR, Sheau KE, Njaka ND, Bayley PJ, deCharms RC. Quantification of adverse events associated with functional MRI scanning and with real-time fMRI-based training. International Journal of Behavioral Medicine. 19: 372-81. PMID 21633905 DOI: 10.1007/s12529-011-9165-6
Journal of Alzheimer's Disease
Advances in Alzheimer's Disease
Bayley PJ, Frisoni GB, Jack CR. Section 2: Structural imaging Advances in Alzheimer's Disease. 2: 45-46. DOI: 10.3233/978-1-60750-793-2-45
Advances in Alzheimer's Disease
Proceedings of the National Academy of Sciences
European Journal of Pharmacology
Proceedings of the National Academy of Sciences
Gold JJ, Smith CN, Bayley PJ, Shrager Y, Brewer JB, Stark CE, Hopkins RO, Squire LR. Item memory, source memory, and the medial temporal lobe: concordant findings from fMRI and memory-impaired patients. Proceedings of the National Academy of Sciences of the United States of America. 103: 9351-6. PMID 16751272 DOI: 10.1073/pnas.0602716103
Filbey FM, Bayley PJ. The 15th annual Summer Institute in Cognitive Neuroscience in review Neuroimage. 19: 471-472. DOI: 10.1016/S1053-8119(03)00055-7
Journal of Pharmacology and Experimental Therapeutics
Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 1051-60. PMID 11082440
Journal of the International Neuropsychological Society
Bayley PJ, Salmon DP, Bondi MW, Bui BK, Olichney J, Delis DC, Thomas RG, Thal LJ. Comparison of the serial position effect in very mild Alzheimer's disease, mild Alzheimer's disease, and amnesia associated with electroconvulsive therapy. Journal of the International Neuropsychological Society : Jins. 6: 290-8.