Yohei Sato, MD, Ph.D

Visiting Instructor

  • PhD, 2016, Jikei University School of Medicine 
  • MD, 2008, Jikei University School of Medicine



Research Interests

I have been dedicated to clinical and basic research of inherited metabolic disorders through my academic career. My goal is to contribute to the children health by promoting translational research. To appreciate the immune regulation is beneficial to the patient fighting against rare immune disease and also the knowledge could be applied to the other disease in children. We believe our research could bring the light to the patients fighting against rare immune disease and improve children health.



  1. Sato Y, Kobayashi H, Higuchi T, Shimada Y, Ida H, Ohashi T. Metabolomic profiling of Pompe disease-induced pluripotent stem cell-derived cardiomyocytes reveals that oxidative stress is associated with cardiac and skeletal muscle pathology. Stem Cells Translational Medicine. Wiley. 2016, (in press)
  2. Sato Y, Kobayashi H, Higuchi T, Shimada Y, Ida H, Ohashi T. TFEB overexpression promotes glycogen clearance of Pompe disease iPSC-derived skeletal muscle. Mol Ther Methods and Clin Dev. NPG. 3, 16054, 2016
  3. Limkul J, Iizuka S, Sato Y, Misaki R, Ohashi T, Ohashi T, Fujiyama K. The production of human glucocerebrosidase in glyco-engineered Nicotiana benthamiana plants. Plant Biotechnology Jouranal. Wiley. p1-13, 2016
  4. Sato Y, Kobayashi H, Higuchi T, Shimada Y, Era T, Kimura S, Eto Y, Ida H, Ohashi T. Disease modeling and lentiviral gene transfer in patient-specific induced pluripotent stem cells from late-onset Pompe diseaase patient. Mol Ther Methods Clin Dev. NPG. 2, 15023, 2015
  5. Sato Y, Fujiwara M, Kobayashi H, Yoshitake M, Hashimoto K, Oto Y, Ida H. Residual glycosaminoglycan accumulation in mitral and aortic valves of a patient with attenuated MPS I (Scheie syndrome) after 6 years of enzyme replacement therapy: Implications for early diagnosis and therapy. Molecular Genetics and Metaborism Reports. Elsevier. 5, 94-97, 2015
  6. Sato Y, Higuchi T, Kobayashi H, Minamisawa S, Ida H, Ohashi T. Lentiviral gene transfer to iPS cells; toward the cardiomyocyte differentiation of Pompe disease-specific iPS cells. Etiology and Morphogenesis of Congenital Heart Disease. Springer. 2015 
  7. Sato Y, Kobayashi H, Shimada Y, Sato S, Fukuda T, Eto Y, Ohashi T, Ida H. Systemic accumulation of undigested lysosomal metabolites in an autopsy case of mucolipidosis type II; autophagic dysfunction in cardiomyocyte. Molecular Genetics and Metabolism. Elsevier. 112(3), 224-228, 2014
  8. Sato Y, Otsubo C, Wada Y, Kubo M, Ida H. Infantile Case of Pneumomediastinum Complicated by Epidural Pneumatoisis. Elmer. International Journal of Clinical Pediatrics. 3(1), 19-21, 2014
  9. Sato Y, Fujiwara M, Kobayashi H, Ida H. Massive Accumulation of Glycosaminoglycans in the Aortic Valve of a Patient With Hunter Syndrome During Enzyme Replacement Therapy. Pediatr Cardiol. Springer. 34(8), 2077-9, 2013 10. Sato Y, Komatsu Y, Kamiya N, Ishida Y, Hosoya R. Risk factors for hospital-acquired hyponatremia among pediatric patients. Pediatri Nephrol. Springer. 26, 829, 2011

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