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Hero Publications

Publications

Researchers strive to enhance early detection methods and develop targeted therapies. Advancements in cancer research offer hope for improved treatments and outcomes, paving the way for a brigther future in heathcare.

Recent Publications

Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis

Neuhöfer P, Roake CM, Kim SJ, Lu RJ, West RB, Charville GW and Artandi SE.

Published Sept. 2021

Regulation of human telomerase in homeostasis and disease

Roake CM and Artandi SE.

Published Apr. 2020

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

Published May. 2019

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, and Artandi SE.

Published Jun. 2018

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

Lin S, Nascimento EM, Gajera C, Chen L, Neuhoefer P, Garbuzov A, Wang S, and Artandi SE.

Published Apr. 2018

Purification of GFRα1+ and GFRα1- Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination

Garbuzov A, Pech MF, Hasegawa K, Sukhwani M, Zhang RJ, Orwig KE, Artandi SE.

Published Feb. 2018

High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells

Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, Artandi SE.

Published Dec. 2015

Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells

Roake CM, Artandi SE.

Published Sept. 2015

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice

Raval A, Behbehani GK, Nguyen le XT, Thomas D, Kusler B, Garbuzov A, Ramunas J, Holbrook C, Park CY, Blau H, Nolan GP, Artandi SE, Mitchell BS.

Published Jul. 2015

Stem Cells and Aging: What's Next?

Artandi SE, Blau HM, de Haan G, Geiger H, Goodell MA, Jones L, Levine RL, Muñoz-Cánoves P, Rodewald HR, Wagers A, Wang ZQ, Yamashita Y.

Published Jun. 2015

A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate

Harel I, Benayoun BA, Machado B, Singh BP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE and Brunet A.

Published Feb. 2015

Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis

Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O'Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, Wernig M.

Published Jan. 2015

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

Freund A, Zhong F, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE.

Published Dec. 2014

Understanding telomere diseases through analysis of patient-derived iPS cells

Batista L and Artandi SE.

Published Aug. 2013

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S, Schluth-Bolard C, Simonet T, Renault VM, Ye J, Djerbi A, Pineau P, Choi J, Artandi S, Dejean A, Plateroti M, Gilson E.

Published Apr. 2013

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends

Zhong F, Batista LZ, Freund A, Pech MF, Venteicher AS, Artandi SE.

Published Aug. 2012 

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

Shkreli, M., Sarin, K.Y., Pech, M.F., Papeta, N., Chang, W., Brockman, S.A., Cheung, P., Lee, E., Kuhnert, F., Olson, J.L., Kuo, C.J., Gharavi, A.G., D'Agati, V.D., and S.E. Artandi.

Published Dec. 2011

Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions

Chu, C., Qu, K., Zhong, F., Artandi, S.E., and H.W. Chang.

Published Nov. 2011

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases

Sebastiano, V., Maeder, M.L., Angstman, J.F., Haddad, B., Khayter, C., Yeo, D.T., Goodwin, M.J., Hawkins, J.S., Ramirez, C.L., Batista, L.F., Artandi, S.E., Wernig, M., and J.K. Joung.

Published Nov. 2011

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

Batista, L.F.Z., Pech, M.F., Zhong, F.Z., Nguyen, H.N., Xie, K.T., Zaug, A.J., Crary, S.M., Choi, J., Sebastiano, V., Cherry, A., Giri, N., Wernig, M., Alter, B.P., Cech, T.R., Savage, S.A, Reijo Pera, R.A, and S.E. Artandi.

Published May. 2011

TRAPping telomerase within the intestinal stem cell niche

Pech, M. F. and S.E. Artandi.

Published Mar. 2011

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

Zhong, F., Savage, S.A, Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B.A., and S.E. Artandi.

Published Jan. 2011

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members

Hong JY, Park JI, Cho K, Gu D, Ji H, Artandi SE, McCrea PD.

Published Dec. 2010

Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice

Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz. J.H., Artandi, S.E., and H.M. Blau.

Published Dec. 2010

Telomeres and telomerase in cancer

Artandi, S.E. and R.A. DePinho.

Published Jan. 2010

Reverse transcribing the code for chromosome stability

Artandi, S.E. and J.P. Cooper.

Published Dec. 2011

Stem cell aging and aberrant differentiation within the niche

Choi, J. and S.E. Artandi.

Published Jul. 2009

Telomerase modulates Wnt signalling by association with target gene chromatin

Park, J.-I., Venteicher, A.S., Hong, J.Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., McLaughlin, M., Veenstra, T.D., Nusse, R., McCrea, P.D., and S. E. Artandi.

Published Jul. 2009

Telomere uncapping, chromosomes, and carcinomas

Batista, L.F. and S.E. Artandi.

Published Jun. 2009

TCAB1: driving telomerase to Cajal bodies

Venteicher, A.S. and S. E. Artandi.

Published May. 2009

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

Venteicher, A.S., Abreu, E.B., Meng, Z., McCann, K.E., Terns, R.M., Veenstra, T.D., Terns, M.P., and S. E. Artandi.

Published Jan. 2009

Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells

Gao, Q., Reynolds, G.E., Miller, D., Cheung, P. Artandi, S. E. and J. P. Murnane.

Published Aug. 2008

Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

Venteicher, A.S., Meng, Z., Mason, P. J., Veenstra, T.D., and S. E. Artandi.

Published Mar. 2008

TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

Choi, J., Southworth, L., Sarin, K., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M.K., Shah, N., Kim, S.K. and S. E. Artandi.

Published Jan. 2008

Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo

Rajaraman, S., Choi, J., Cheung, P., Beaudry, V., Moore, H. and S. E. Artandi.

Published Nov. 2007

Aging, graying and loss of melanocyte stem cells

Sarin, K. and S. E. Artandi.

Published Fall 2007

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse

Maser, R.S., Wong, K.K., Sahin, E., Xia, H., Naylor, M., Hedberg, H.M., Artandi, S.E., and R.A. DePinho.

Published Mar. 2007 

Telomeres, telomerase, and human disease

Artandi, S.E.

Published Sept. 2006

Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

Artandi, S.E.

Published May. 2006

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

Middleman, E., Choi, J., Venteicher, A. S., Cheung, P., and S.E. Artandi.

Published Mar. 2006

Conditional telomerase induction causes proliferation of hair follicle stem cells

Sarin, K. Y., Cheung, P., Lee, E., Gilison, D., Artandi, M.K., Oro, A., and S. E. Artandi.

Published Aug. 2005

Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer

Artandi, S.E. and Attardi, L.D.

Published Jun. 2005

Complex roles for telomeres and telomerase in breast carcinogenesis

Artandi, S.E.

Published Oct. 2003

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

O'Hagan, R., Chang, S., Maser, R., Mohan, R., Artandi, S.E., Chin, L. and R.A. DePinho.

Published Aug. 2002

Telomere shortening and cell fates in mouse models of neoplasia

Artandi, S.E.

Published Jan. 2002

Constitutive telomerase expression promotes mammary carcinomas in aging mice

Artandi, S. E., Alson, S., Tietze, M., Sharpless, N., Ye, S., Greenberg, R., Castrillon, D., Horner, J., Weiler, S., Carrasco, R. and R. DePinho.

Published Jun. 2002

A critical role for telomeres in suppressing and facilitating carcinogenesis

Artandi, S.E., and DePinho R.A.

Published Feb. 2000

Mice without telomerase: what can they teach us about human cancer?

Artandi, S.E., and DePinho R.A.

Published Aug. 2000

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang S., Weiler, S.R., Ganesan S., Chaudhura J., Zhu C., Artandi S.E., Rudolph K.L., Gottlieb G.J., Chin L., Alt F.W., and DePinho, R.A.

Published Sept. 2000

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

Artandi, S.E., Chang, S., Lee, S.-L., Alson S., Gottlieb, G.J., Chin, L., and DePinho, R.A.

Published Aug. 2000

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

Chin, L., Artandi, S.E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., and DePinho, R.

Published May. 1999