Selected Publications

  1. Horton TM, Kraemer BR, Annes JP. Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas. STAR Protoc. 2021 Jan 12;2(1):100263. doi: 10.1016/j.xpro.2020.100263. PMID: 33490979; PMCID: PMC7806521.
  2. Guenthart BA, Trope W, Keeyapaj W, Weiel JJ, Edmonson A, MacArthur JW, Annes JP, Woo YJ, Lui NS. Intracardiac paragangliomas: surgical approach and perioperative management. Gen Thorac Cardiovasc Surg. 2020 Oct 19. doi:10.1007/s11748-020-01503-2. Epub ahead of print. PMID: 33074472.
  3. Alobuia WM, Ammar S, Tyagi M, Ghosh C, Gunda V, Annes JP, Kebebew E. Probability of positive genetic testing in patients diagnosed with pheochromocytoma and paraganglioma: Criteria beyond a family history. Surgery. 2020 Oct 3:S0039-6060(20)30559-6. doi: 10.1016/j.surg.2020.08.027. Epub ahead of print. PMID: 33023754
  4. Alobuia W, Annes J, Kebebew E. Genetic testing in endocrine surgery: Opportunities for precision surgery. Surgery. 2020 Aug;168(2):328-334. doi:10.1016/j.surg.2020.03.009. Epub 2020 May 4. PMID: 32376047
  5. Horton TM, Sundaram V, Lee CH, et al. PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker. Sci Rep. 2020;10(1):10943. 
  6. Allegretti PA,  Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP. Generation of Highly Potent DYRK1A-Dependent Inducers of Human β-Cell Replication via Multi-Dimensional Compound Optimization. Bioorg Med Chem. 2020 Jan 1;28(1):115193
  7. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells. Cell Chem Biol. 2019 Feb 21;26(2):213-222. PMID: 30527998.
  8. Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D, Shalizi A, Smith M, Armstrong NA, Annes JP. CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. Endocrinology. 2018 Sep 1;159(9):3143-3157. PMID: 29514186.
  9. Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018 Jan 12;293(2):567-578. PMID: 29183997.
  10. Navarro G, Abdolazimi Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes. 2017 Jul;66(7):1928-1938. PMID: 28468960.
  11. Hosseini-Nassab N, Samanta D, Abdolazimi Y, Annes JP, Zare RN. Electrically controlled release of insulin using polypyrrole nanoparticles. Nanoscale. 2017 Jan 7;9(1):143-149. doi: 10.1039/c6nr08288b. Epub 2016 Dec 8.
  12. Zhao, Z., Abdolazimi, Y., Armstrong, N.A.Annes, J.P. 2016. A high-content in vitro pancreatic islet beta-cell replication screening platform. JOVE
  13. Zhao, Z., Low, Y.S., Armstrong, N.A., Ryu, J.H., Sun, S.A., Arvanites, A.C., Hollister-Lock, J., Shah, N.H., Weir, G.C., and Annes, J.P. 2014. Repurposing cAMP-modulating medications to promote beta-cellreplication. Mol Endocrinol 28:1682-1697.  *Selected by the Endocrine Society as THE BEST of BASIC RESEARCH 2014
  14. Nichols, R.J., New, C., and Annes, J.P. 2014. Adult tissue sources for new beta cells. Transl Res 163:418-431.
  15. Vaidya, A., Underwood, P.C., Annes, J.P., Sun, B., Williams, G.H., Forman, J.P., and Williams, J.S. 2013. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism 62:539-547.
  16. Wei, K., Piecewicz, S.M., McGinnis, L.M., Taniguchi, C.M., Wiegand, S.J., Anderson, K., Chan, C.W., Mulligan, K.X., Kuo, D., Yuan, J., et al. 2013. A liver Hif-2alpha-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med 19:1331-1337.
  17. Chen, C.A., Carolan, P.C., and Annes, J.P. 2012. In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents. PLoS One 7:e44600.
  18. Bar-Lev, A., and Annes, J.P. 2012. Genetics of adrenocortical disease: an update. Curr Opin Endocrinol Diabetes Obes 19:159-167.
  19. Annes, J.P., Ryu, J.H., Lam, K., Carolan, P.J., Utz, K., Hollister-Lock, J., Arvanites, A.C., Rubin, L.L., Weir, G., and Melton, D.A. 2012. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication. Proc Natl Acad Sci U S A 109:3915-3920.
  20. Volpicelli, E.R., Doyle, L., Annes, J.P., Murray, M.F., Jacobsen, E., Murphy, G.F., and Saavedra, A.P. 2011. Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol 38:280-285.
  21. Annes, J.P., Giovanni, M.A., and Murray, M.F. 2010. Risks of presymptomatic direct-to-consumer genetic testing. N Engl J Med 363:1100-1101.
  22. Annes, J.P., Chen, Y., Munger, J.S., and Rifkin, D.B. 2004. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165:723-734.
  23. Annes, J., Vassallo, M., Munger, J.S., and Rifkin, D.B. 2004. A genetic screen to identify latent transforming growth factor beta activators. Anal Biochem 327:45-54.
  24. Krishnan, S., Deora, A.B., Annes, J.P., Osoria, J., Rifkin, D.B., and Hajjar, K.A. 2004. Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol 265:140-154.
  25. Annes, J.P., Munger, J.S., and Rifkin, D.B. 2003. Making sense of latent TGFbeta activation. J Cell Sci 116:217-224.
  26. Chen, Y., Dabovic, B., Annes, J.P., and Rifkin, D.B. 2002. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett 517:277-280.
  27. Annes, J.P., Rifkin, D.B., and Munger, J.S. 2002. The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett 511:65-68.
  28. Gualandris, A., Annes, J.P., Arese, M., Noguera, I., Jurukovski, V., and Rifkin, D.B. 2000. The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. Mol Biol Cell 11:4295-4308.
  29. Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L., et al. 2000. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 404:402-407.