Clinical and Translational Research Group in Nonmelanoma Skin Cancer and Human Skin Aging

Stanford University School of Medicine's Center for Advanced Dermatologic Investigation is the Dermatology Department's Clinical Trials Unit. 

Directed by Anne  Lynn S. Chang, MD., the Center is home to 12-15 ongoing clinical studies, investigating the safety and efficacy of new and currently available drugs and over-the-counter medications.  The Center works with Stanford's own panel on medical research, leading pharmaceutical companies,and the Food and Drug Administration to safely and ethically expand the medical field's knowledge of dermatologic treatments.  New studies begin regularly, and the Center continues to recruit patients with skin cancer (including basal cell carcinomas, squamous cell carcinoma, skin aging and sun damage, ) and other dermatologic diseases for ongoing studies. 

Nonmelanoma Skin Cancer:

Skin cancers may arise when normal aging processes go awry. Recent advances in our understanding of basal cell skin cancer biology have enabled the development of cutting edge study drugs which combat tumor growth. In addition we are working with medical onchologists, radiation onchologists and surgeon to combine therapy to fight skin cancer. We are currently home to a number of clinical trials at the fore front of potential therapy for advanced or metastatic basal cell cancer and squamous cell cancer. In addition, we seek to understand the biology of skin cancers and to identify molecular predictors for treatment success.

Skin Aging Studies:

Normal skin again may serve as a brake for development of skin cancers. We seek to understand the human aging process as it relates to skin on a fundamental level. To this end, our studies focus on clinical and translational research efforts ranging from: (1) the analysis of gene changes which predispose individuals to exceptionally youthful skin to (2) molecular signatures that may be biomarkers for aging skin to (3) the careful study of new candidate agents which might affect the skin aging process.


On December 4, 2014, Dr. Anne Chang was interviewed by Dr. Michael Whitlow of New York University's Langone Medical Center on Sirius XM Satellite Radio about her research on aging of the skin. Please use the links below to read the interview transcript or listen to the interview on Sirius Radio.

Transcript of Dr. Anne Chang's Interview

Instructions on listening to the interview on Sirius XM Satellite Radio