Andreasson Lab News
Study reveals immune driver of brain aging
Scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system’s front-line soldiers.
New Method for Tackling Stroke Restrains an Overactive Immune System
Shutting down an inflammatory molecule could potentially provide treatment days after onset.
Scientists shrink stroke damage in mice by calming immune cells outside brain
Instead of trying to fix stroke-damaged nerve cells, Stanford scientists took aim at a set of first-responder immune cells that live outside the brain but rush to the site of a stroke. It worked.
Boosting the Brain's Immune System - Dr. Katrin Andreasson
Previous research has shown that NSAIDS, a class of anti-inflammatory drug, can help prevent Alzheimer’s in cognitively normal people, but it wasn’t clear why. NSAIDs do not work once any memory loss has begun, so this is a real preventive effect. Now, exciting new research has identified a potential culprit - malfunctioning immune cells in the brain. This discovery has opened up new avenues for treatment.
Brain Traffic Control
With new brain-scanning methods, scientists aim to make Alzheimer’s disease history
Alzheimer’s Disease: What Stands Between Us and a Cure?
Our understanding of Alzheimer’s disease is better than ever before. So why are we still so far from a cure?
Blocking receptor in brain's immune cells counters Alzheimer's in mice, study finds
Brain cells called microglia chew up toxic substances and cell debris, calm inflammation and make nerve-cell-nurturing substances. New research shows that keeping them on the job may prevent neurodegeneration.
Another big step toward building a better aspirin tablet
In the new study, which appears in the Journal of Neuroscience, Andreasson and her colleagues (including fellow Stanford neuroscientist Marion Buckwalter, MD, PhD,) specifically blocked PGE2's function in mice's microglia.
Untangling the inflammation/Alzheimer's connection
It's been known for some time that otherwise relatively healthy people who, for one reason or another, are long-time users of non-steroidal anti-inflammatory drugs, or NSAIDs, such as aspirin, ibuprofen (Advil), naproxen (Aleve), and others have a reduced risk of developing Alzheimer's disease. Stanford neuroscientist Katrin Andreasson, MD, just published a study in Annals of Neurology that suggests why this might be so.