Recent Peer-Reviewed Research Publications

2024 Publications

Mack DP, Dribin TE, Turner PJ, Wasserman RL, Hanna MA, Shaker M, Tang MLK, Rodríguez Del Río P, Sobolewski B, Abrams EM, Anagnostou A, Arasi S, Bajowala S, Bégin P, Cameron SB, Chan ES, Chinthrajah S, Clark AT, Detjen P, du Toit G, Ebisawa M, Elizur A, Factor JM, Greiwe J, O'B Hourihane J, Hughes SW, Jones DH, Muraro A, Nowak-Wegrzyn A, Patel NB, Scurlock AM, Shah AN, Sindher SB, Tilles S, Vickery BP, Wang J, Windom HH, Greenhawt M. Preparing Patients for Oral Immunotherapy (PPOINT): International Delphi consensus for procedural preparation and consent. J Allergy Clin Immunol. 2024 Mar 28:S0091-6749(24)00238-0. doi: 10.1016/j.jaci.2024.02.019. Epub ahead of print. PMID: 38597862.
Schuetz JP, Anderson B, Sindher SB. New biologics for food allergy. Curr Opin Allergy Clin Immunol. 2024 Mar 29. doi: 10.1097/ACI.0000000000000981. Epub ahead of print. PMID: 38547423.
Petroni D, Bégin P, Bird JA, Brown-Whitehorn T, Chong HJ, Fleischer DM, Gagnon R, Jones SM, Leonard S, Makhija MM, Oriel RC, Shreffler WG, Sindher SB, Sussman GL, Yang WH, Bee KJ, Bois T, Campbell DE, Green TD, Rutault K, Sampson HA, Wood RA. Varying Doses of Epicutaneous Immunotherapy With Viaskin Milk vs Placebo in Children With Cow's Milk Allergy: A Randomized Clinical Trial. JAMA Pediatr. 2024 Apr 1;178(4):345-353. doi: 10.1001/jamapediatrics.2023.6630. Erratum in: JAMA Pediatr. 2024 Apr 1;178(4):421. PMID: 38407859; PMCID: PMC10897821.
Wood RA, Togias A, Sicherer SH, Shreffler WG, Kim EH, Jones SM, Leung DYM, Vickery BP, Bird JA, Spergel JM, Iqbal A, Olsson J, Ligueros-Saylan M, Uddin A, Calatroni A, Huckabee CM, Rogers NH, Yovetich N, Dantzer J, Mudd K, Wang J, Groetch M, Pyle D, Keet CA, Kulis M, Sindher SB, Long A, Scurlock AM, Lanser BJ, Lee T, Parrish C, Brown-Whitehorn T, Spergel AKR, Veri M, Hamrah SD, Brittain E, Poyser J, Wheatley LM, Chinthrajah RS. Omalizumab for the Treatment of Multiple Food Allergies. N Engl J Med. 2024 Mar 7;390(10):889-899. doi: 10.1056/NEJMoa2312382. Epub 2024 Feb 25. PMID: 38407394.
Lejeune S, Kaushik A, Parsons ES, Chinthrajah S, Snyder M, Desai M, Manohar M, Prunicki M, Contrepois K, Gosset P, Deschildre A, Nadeau K. Untargeted metabolomic profiling in children identifies novel pathways in asthma and atopy. J Allergy Clin Immunol. 2024 Feb;153(2):418-434. doi: 10.1016/j.jaci.2023.09.040. Epub 2023 Oct 29. PMID: 38344970.
Balz K, Grange M, Pegel U, Karamya ZA, Mello M, Zhou X, Berger T, Bloch K, Dunham D, Chinthrajah S, Nadeau K, Luche H, Skevaki C. A novel mass cytometry protocol optimized for immunophenotyping of low-frequency antigen-specific T cells. Front Cell Infect Microbiol. 2024 Jan 15;13:1336489. doi: 10.3389/fcimb.2023.1336489. PMID: 38287974; PMCID: PMC10822892.
Marques-Mejias A, Bartha I, Ciaccio CE, Chinthrajah RS, Chan S, Hershey GKK, Hui-Beckman JW, Kost L, Lack G, Layhadi JA, Leung DYM, Marshall HF, Nadeau KC, Radulovic S, Rajcoomar R, Shamji MH, Sindher S, Brough HA. Skin as the target for allergy prevention and treatment. Ann Allergy Asthma Immunol. 2024 Jan 20:S1081-1206(24)00001-2. doi: 10.1016/j.anai.2023.12.030. Epub ahead of print. PMID: 38253125.
Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H; IMPACC Network; Maecker HT, Rouphael N, Diray-Arce J, Wigdahl B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition. Nat Commun. 2024 Jan 9;15(1):404. doi: 10.1038/s41467-023-44211-0. PMID: 38195739; PMCID: PMC10776791.
Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, Dandekar R, Shannon CP, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, van Bakel H, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS, Erle DJ, Langelier CR, Eckalbar W, Bosinger SE; IMPACC Network; Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC, Montgomery RR, Becker PM, Rouphael N. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nat Commun. 2024 Jan 3;15(1):216. doi: 10.1038/s41467-023-44090-5. PMID: 38172101; PMCID: PMC10764789.

2023 Publications

Marshall HF, Leung DYM, Lack G, Sindher S, Ciaccio CE, Chan S, Nadeau KC, Brough HA. Topical steroid withdrawal and atopic dermatitis. Ann Allergy Asthma Immunol. 2024 Apr;132(4):423-425. doi: 10.1016/j.anai.2023.12.022. Epub 2023 Dec 23. PMID: 38142858.
Santos AF, Worm M, Kurita S, Wong T, Contato D, Pirillo E, Esteban AE, Tassinari P, Perna F, Chinthrajah RS. Living with food allergies: the experiences of adult patients and caregivers. Front Allergy. 2023 Nov 6;4:1272851. doi: 10.3389/falgy.2023.1272851. PMID: 38026132; PMCID: PMC10658712.
Sindher SB, Fiocchi A, Zuberbier T, Arasi S, Wood RA, Chinthrajah RS. The Role of Biologics in the Treatment of Food Allergy. J Allergy Clin Immunol Pract. 2024 Mar;12(3):562-568. doi: 10.1016/j.jaip.2023.11.032. Epub 2023 Nov 25. PMID: 38013157.
Anagnostou A, Upton JEM, Chinthrajah RS. The promise of sublingual and other immunotherapy options for infants and toddlers with food allergy. J Allergy Clin Immunol. 2024 Jan;153(1):95-97. doi: 10.1016/j.jaci.2023.11.009. Epub 2023 Nov 20. PMID: 37992817.
Castaño N, Chua K, Kaushik A, Kim S, Cordts SC, Nafarzadegan CD, Hofmann GH, Seastedt H, Schuetz JP, Dunham D, Parsons ES, Tsai M, Cao S, Desai M, Sindher SB, Chinthrajah RS, Galli SJ, Nadeau KC, Tang SKY. Combining avidin with CD63 improves basophil activation test accuracy in classifying peanut allergy. Allergy. 2024 Feb;79(2):445-455. doi: 10.1111/all.15930. Epub 2023 Nov 2. PMID: 37916710; PMCID: PMC10842984.
Wimmers F, Burrell AR, Feng Y, Zheng H, Arunachalam PS, Hu M, Spranger S, Nyhoff LE, Joshi D, Trisal M, Awasthi M, Bellusci L, Ashraf U, Kowli S, Konvinse KC, Yang E, Blanco M, Pellegrini K, Tharp G, Hagan T, Chinthrajah RS, Nguyen TT, Grifoni A, Sette A, Nadeau KC, Haslam DB, Bosinger SE, Wrammert J, Maecker HT, Utz PJ, Wang TT, Khurana S, Khatri P, Staat MA, Pulendran B. Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell. 2023 Oct 12;186(21):4632-4651.e23. doi: 10.1016/j.cell.2023.08.044. Epub 2023 Sep 29. PMID: 37776858; PMCID: PMC10724861.
Keet C, Sicherer SH, Bunyavanich S, Visness C, Fulkerson PC, Togias A, Davidson W, Perry S, Hamrah S, Calatroni A, Robinson K, Dunaway L, Davis CM, Anvari S, Leong-Kee SM, Hershey GK, DeFranco E, Devonshire A, Kim H, Joseph C, Davidson B, Strong NK, Tsuang AJ, Groetch M, Wang J, Dantzer J, Mudd K, Aina A, Shreffler W, Yuan Q, Simmons V, Leung DYM, Hui-Beckman J, Ramos JA, Chinthrajah S, Winn V, Sindher T, Jones SM, Manning NA, Scurlock AM, Kim E, Stuebe A, Gern JE, Singh AM, Krupp J, Wood RA. The SunBEAm birth cohort: Protocol design. J Allergy Clin Immunol Glob. 2023 Aug;2(3):100124. doi: 10.1016/j.jacig.2023.100124. Epub 2023 Jun 3. PMID: 37771674; PMCID: PMC10509956.
Sindher SB, Sharma R, Yarlagadda M, Chin AR, Chinthrajah RS. Recent Mechanistic Studies in Allergic Diseases. Int J Mol Sci. 2023 Sep 20;24(18):14312. doi: 10.3390/ijms241814312. PMID: 37762615; PMCID: PMC10531635.
Croote D, Wong JJW, Pecalvel C, Leveque E, Casanovas N, Kamphuis JBJ, Creeks P, Romero J, Sohail S, Bedinger D, Nadeau KC, Chinthrajah RS, Reber LL, Lowman HB. Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy. J Allergy Clin Immunol. 2024 Jan;153(1):182-192.e7. doi: 10.1016/j.jaci.2023.08.035. Epub 2023 Sep 23. PMID: 37748654; PMCID: PMC10766438.
Long A, Ferretti-Gallon JJ, Chin AR, Chinthrajah RS, Sindher SB. Neuroimmune pathways and allergic disease: An overview. Ann Allergy Asthma Immunol. 2023 Nov;131(5):547-549. doi: 10.1016/j.anai.2023.06.029. Epub 2023 Jul 28. PMID: 37517658.
Greenhawt M, Dribin TE, Abrams EM, Shaker M, Chu DK, Golden DB, Akin C, Anagnostou A, ALMuhizi F, Alqurashi W, Arkwright P, Baldwin JL, Banerji A, Bégin P, Ben-Shoshan M, Bernstein J, Bingeman TA, Bindslev-Jensen C, Blumenthal K, Byrne A, Cahil J, Cameron S, Campbell D, Campbell R, Cavender M, Chan ES, Chinthrajah S, Comberiatti P, Eastman JJ, Ellis AK, Fleischer DM, Fox A, Frischmeyer-Guerrerio PA, Gagnon R, Garvey LH, Grayson MH, Clarisse Isabwe GA, Hartog N, Hendron D, Horner CC, O'B Hourihane J, Iglesia E, Kan M, Kaplan B, Katelaris CH, Kim H, Kelso JM, Kahn DA, Lang D, Ledford D, Levin M, Lieberman JA, Loh R, Mack DP, Mazer B, Mody K, Mosnaim G, Munblit D, Mustafa SS, Nanda A, Nathan R, Oppenheimer J, Otani IM, Park M, Pawankar R, Perrett KP, Peter J, Phillips EJ, Picard M, Pitlick M, Ramsey A, Rasmussen TH, Rathkopf MM, Reddy H, Robertson K, Rodriguez Del Rio P, Sample S, Sheshradi A, Shiek J, Sindher SB, Spergel JM, Stone CA, Stukus D, Tang ML, Tracy JM, Turner PJ, Vander Leek TK, Wallace DV, Wang J, Wasserman S, Weldon D, Wolfson AR, Worm M, Yacoub MR. Updated Guidance Regarding The Risk ofAllergic Reactions to COVID-19 Vaccines and Recommended Evaluation and Management: A GRADE Assessment, and International Consensus Approach. J Allergy Clin Immunol. 2023 Jun 7:S0091-6749(23)00746-7. doi: 10.1016/j.jaci.2023.05.019. Epub ahead of print. PMID: 37295474; PMCID: PMC10247143.
Pouessel G, Deschildre A, Dribin TE, Ansotegui IJ, Cardona V, Chinthrajah RS, Ebisawa M, Muraro A, Roberts G, Sampson HA, Waserman S, Wood RA, Worm M, Turner PJ. Refractory Anaphylaxis: A New Entity for Severe Anaphylaxis. J Allergy Clin Immunol Pract. 2023 Jul;11(7):2043-2048. doi: 10.1016/j.jaip.2023.04.037. Epub 2023 May 10. PMID: 37172716.
Greenhawt M, Sindher SB, Wang J, O'Sullivan M, du Toit G, Kim EH, Albright D, Anvari S, Arends N, Arkwright PD, Bégin P, Blumchen K, Bourrier T, Brown-Whitehorn T, Cassell H, Chan ES, Ciaccio CE, Deschildre A, Divaret-Chauveau A, Dorris SL, Dorsey MJ, Eiwegger T, Erlewyn-Lajeunesse M, Fleischer DM, Ford LS, Garcia-Lloret M, Giovannini-Chami L, Hourihane JO, Jay N, Jones SM, Kerns LA, Kloepfer KM, Leonard S, Lezmi G, Lieberman JA, Lomas J, Makhija M, Parrish C, Peake J, Perrett KP, Petroni D, Pfützner W, Pongracic JA, Quinn P, Robison RG, Sanders G, Schneider L, Sharma HP, Trujillo J, Turner PJ, Tuttle K, Upton JE, Varshney P, Vickery BP, Vogelberg C, Wainstein B, Wood RA, Bee KJ, Campbell DE, Green TD, Rouissi R, Peillon A, Bahnson HT, Bois T, Sampson HA, Burks AW. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy. N Engl J Med. 2023 May 11;388(19):1755-1766. doi: 10.1056/NEJMoa2212895. PMID: 37163622.
Groetch M, Mudd K, Woch M, Schaible A, Gray BE, Babineau DC, Bird JA, Jones S, Kim EH, Lanser BJ, Poyser J, Rogers N, Shreffler W, Sicherer S, Spergel AKR, Spergel J, Vickery BP, Chinthrajah RS, Wood R. Retail Food Equivalents for Post-Oral Immunotherapy Dosing in the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food-Allergic Children and Adults (OUtMATCH) Clinical Trial. J Allergy Clin Immunol Pract. 2023 Feb;11(2):572-580.e2. doi: 10.1016/j.jaip.2022.10.022. Epub 2022 Oct 28. PMID: 37113037; PMCID: PMC10147955.
Sindher SB, Hillier C, Anderson B, Long A, Chinthrajah RS. Treatment of food allergy: Oral immunotherapy, biologics, and beyond. Ann Allergy Asthma Immunol. 2023 Jul;131(1):29-36. doi: 10.1016/j.anai.2023.04.023. Epub 2023 Apr 25. PMID: 37100276; PMCID: PMC10330596.
Stankovich GA, Warren CM, Gupta R, Sindher SB, Chinthrajah RS, Nadeau KC. Food allergy risks and dining industry - an assessment and a path forward. Front Allergy. 2023 Mar 29;4:1060932. doi: 10.3389/falgy.2023.1060932. PMID: 37064717; PMCID: PMC10090668.
Sindher SB, Chin AR, Aghaeepour N, Prince L, Maecker H, Shaw GM, Stevenson DK, Nadeau KC, Snyder M, Khatri P, Boyd SD, Winn VD, Angst MS, Chinthrajah RS. Advances and potential of omics studies for understanding the development of food allergy. Front Allergy. 2023 Mar 24;4:1149008. doi: 10.3389/falgy.2023.1149008. PMID: 37034151; PMCID: PMC10080041.
Calise J, DeBerg H, Garabatos N, Khosa S, Bajzik V, Calderon LB, Aldridge K, Rosasco M, Ferslew BC, Zhu T, Smulders R, Wheatley LM, Laidlaw TM, Qin T, Chichili GR, Adelman DC, Farrington M, Robinson D, Jeong D, Jones SM, Sanda S, Larson D, Kwok WW, Baloh C, Nepom GT, Wambre E; IMPACT. Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy. J Allergy Clin Immunol. 2023 Jul;152(1):155-166.e9. doi: 10.1016/j.jaci.2023.03.020. Epub 2023 Mar 30. PMID: 37003475; PMCID: PMC10330178.
Gao F, Mallajoysula V, Arunachalam PS, van der Ploeg K, Manohar M, Röltgen K, Yang F, Wirz O, Hoh R, Haraguchi E, Lee JY, Willis R, Ramachandiran V, Li J, Kathuria KR, Li C, Lee AS, Shah MM, Sindher SB, Gonzalez J, Altman JD, Wang TT, Boyd SD, Pulendran B, Jagannathan P, Nadeau KC, Davis MM. Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8⁺ T cell responses post SARS-CoV-2 infection. Immunity. 2023 Apr 11;56(4):864-878.e4. doi: 10.1016/j.immuni.2023.03.005. Epub 2023 Mar 16. PMID: 36996809; PMCID: PMC10017386.
Arasi S, Nurmatov U, Dunn-Galvin A, Roberts G, Turner PJ, Shinder SB, Gupta R, Eigenmann P, Nowak-Wegrzyn A, Ansotegui IJ, Rivas MF, Petrou S, Tanno LK, Vazquez-Ortiz M, Vickery B, Wong G, Alvaro-Lozano M, Asaria M, Begin P, Bozzola M, Boyle R, Brough H, Cardona V, Chinthrajah RS, Cianferoni A, Deschildre A, Fleischer D, Gazzani F, Gerdts J, Giannetti M, Greenhawt M, Guzmán MA, Hossny E, Kauppi P, Jones C, Lucidi F, Monge Ortega OP, Munblit D, Muraro A, Pajno G, Podestà M, Rodriguez Del Rio P, Said M, Santos A, Shaker M, Szajewska H, Venter C, Warren C, Winders T, Ebisawa M, Fiocchi A. WAO consensus on DEfinition of Food Allergy SEverity (DEFASE). World Allergy Organ J. 2023 Mar 2;16(3):100753. doi: 10.1016/j.waojou.2023.100753. PMID: 36910595; PMCID: PMC9996094.
Lee AS, Parsons ES, Chang I, Dunham D, Chinthrajah RS, Nadeau KC. Quantitative analysis of urinary cytokines in food-allergic and healthy individuals. Allergy. 2023 Mar 11. doi: 10.1111/all.15707. Epub ahead of print. PMID: 36905306.
Parsons ES, Liu F, Kaushik A, Lee A, Schuetz J, Dunham D, Seastedt H, Ogulur I, Heider A, Tan G, Shah A, Cao S, Smith E, Kost L, Acharya S, Prunicki M, Rothenberg M, Sindher S, Leib R, Akdis CA, Nadeau K, Lejeune S. Detection of gut and mucosal peptides through TOMAHAQ in healthy individuals. Allergy. 2023 Jul;78(7):2052-2055. doi: 10.1111/all.15698. Epub 2023 Mar 20. PMID: 36872560.
Sindher SB, Barshow S, Tirumalasetty J, Arasi S, Atkins D, Bauer M, Bégin P, Collins MH, Deschildre A, Doyle AD, Fiocchi A, Furuta GT, Garcia-Lloret M, Mennini M, Rothenberg ME, Spergel JM, Wang J, Wood RA, Wright BL, Zuberbier T, Chin AR, Long A, Nadeau KC, Chinthrajah RS. The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders. J Allergy Clin Immunol. 2023 Mar;151(3):595-606. doi: 10.1016/j.jaci.2023.01.007. PMID: 36872039; PMCID: PMC9993424.
Wong L, Kost L, Anderson B, Long A, Sindher SB, Chinthrajah RS, Collins WJ. Transitioning from epicutaneous to oral peanut immunotherapy. Front Allergy. 2023 Feb 6;4:1089308. doi: 10.3389/falgy.2023.1089308. PMID: 36814725; PMCID: PMC9939758.
CWimmers F, Burrell AR, Feng Y, Zheng H, Arunachalam PS, Hu M, Spranger S, Nyhoff L, Joshi D, Trisal M, Awasthi M, Bellusci L, Ashraf U, Kowli S, Konvinse KC, Yang E, Blanco M, Pellegrini K, Tharp G, Hagan T, Chinthrajah RS, Grifoni A, Sette A, Nadeau KC, Haslam DB, Bosinger SE, Wrammert J, Maecker HT, Utz PJ, Wang TT, Khurana S, Khatri P, Staat MA, Pulendran B. Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life. medRxiv [Preprint]. 2023 Jan 31:2023.01.28.23285133. doi: 10.1101/2023.01.28.23285133. PMID: 36778389; PMCID: PMC9915811.
Zuberbier T, Wood RA, Bindslev-Jensen C, Fiocchi A, Chinthrajah RS, Worm M, Deschildre A, Fernandez-Rivas M, Santos AF, Jaumont X, Tassinari P. Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2023 Apr;11(4):1134-1146. doi: 10.1016/j.jaip.2022.11.036. Epub 2022 Dec 15. PMID: 36529441.
Zhang Y, Bhardwaj SR, Vilches A, Breksa A, Lyu SC, Chinthrajah S, Nadeau KC, Jin T. IgE binding epitope mapping with TL1A tagged peptides. Mol Immunol. 2023 Jan;153:194-199. doi: 10.1016/j.molimm.2022.12.001. Epub 2022 Dec 15. PMID: 36527758.
Zhang Y, Bhardwaj SR, Lyu SC, Chinthrajah S, Nadeau KC, Li C. Expression, purification, characterization, and patient IgE reactivity of new macadamia nut iso-allergen. Protein Expr Purif. 2023 Mar;203:106211. doi: 10.1016/j.pep.2022.106211. Epub 2022 Nov 30. PMID: 36462715.
Skevaki C, Chinthrajah RS, Fomina D, Rohde G, Cao S, He Z, Serdotetskova S, Seidemann C, Grünewaldt A, Vengadeswaran A, Xie M, Karsonova A, Karaulov A, Nadeau KC, Chung HR, Renz H. Comorbidity defines asthmatic patients' risk of COVID-19 hospitalization: A global perspective. J Allergy Clin Immunol. 2023 Jan;151(1):110-117. doi: 10.1016/j.jaci.2022.09.039. Epub 2022 Nov 3. PMID: 36336123; PMCID: PMC9632231.
Dantzer JA, Kim EH, Chinthrajah RS, Wood RA. Treatment for food allergy: Current status and unmet needs. J Allergy Clin Immunol. 2023 Jan;151(1):1-14. doi: 10.1016/j.jaci.2022.08.008. Epub 2022 Aug 23. PMID: 35998790.

2022 Publications

Sampath V, Nadeau KC, Ebi KL, Narvaez D, Tessema MT, Pak-Gorstein S, Darmstadt GL. Improving planetary health is integral to improving children's health-a call to action. Pediatr Res. 2022. Dec 23. [Epub ahead of Print].
Goldman JD, Wang K, Röltgen K, Nielsen SCA, Roach JC, Naccache SN, Yang F, Wirz OF, Yost KE, Lee JY, Chun K, Wrin T, Petropoulos CJ, Lee I, Fallen S, Manner PM, Wallick JA, Algren HA, Murray KM, Hadlock J, Chen D, Dai CL, Yuan D, Su Y, Jeharajah J, Berrington WR, Pappas GP, Nyatsatsang ST, Greninger AL, Satpathy AT, Pauk JS, Boyd SD, Heath JR. Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report. Vaccines (Basel). 2022 Dec 20;11(1):5.
Fathman CG, Yip L, Gómez-Martín D, Yu M, Seroogy CM, Hurt CR, Lin JT, Jenks JA, Nadeau KC, Soares L. How GRAIL controls Treg function to maintain self-tolerance. Front Immunol. 2022 Dec 8;13:1046631.
Jung YS, Sampath V, Prunicki M, Aguilera J, Allen H, LaBeaud D, Veidis E, Barry M, Erny B, Patel L, Akdis C, Akdis M, Nadeau K. Characterization and regulation of microplastic pollution for protecting planetary and human health. Environ Pollut. 2022 Dec 15;315:120442.
Tursi AR, Saba NK, Dunham D, Manohar M, Peters RL, Saffery R, Koplin JJ, Nadeau KC, Neeland MR, Andorf S. Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants. Sci Data. 2022 Dec 1;9(1):738.
Zhang Y, Bhardwaj SR, Lyu SC, Chinthrajah S, Nadeau KC, Li C. Expression, purification, characterization, and patient IgE reactivity of new macadamia nut iso-allergen. Protein Expr Purif. 2022 Nov 30:106211.
Kanchan K, Shankar G, Huffaker MF, Bahnson HT, Chinthrajah RS, Sanda S, Manohar M, Ling H, Paschall JE, Toit GD, Ruczinski I, Togias A, Lack G, Nadeau KC, Jones SM, Nepom GT, Mathias RA. HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success. Front Immunol. 2022 Nov 18;13:941839.
Liu EG, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro JR, Chinthrajah S, Sindher T, Manohar M, Quake AZ, Nadeau K, Burks AW, Kim EH, Kulis MD, Henning AK, Jones SM, Leung DYM, Sicherer SH, Wood RA, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth SC. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Sci Transl Med. 2022 Nov 16;14(671):eabq0599.
Sarabu C, Deonarine A, Leitner S, Fayanju O, Fisun M, Nadeau K. Climate change and health informatics: pilot survey of perspectives across the field. J Am Med Inform Assoc. 2022 Nov 14;29(12):2117-2123.
Kaushik A, Dunham D, Han X, Do E, Andorf S, Gupta S, Fernandes A, Kost LE, Sindher SB, Yu W, Tsai M, Tibshirani R, Boyd SD, Desai M, Maecker HT, Galli SJ, Chinthrajah RS, DeKruyff RH, Manohar M, Nadeau KC. CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy. Nat Commun. 2022 Nov 4;13(1):6646.
Akdis CA, Nadeau KC. Human and planetary health on fire. Nat Rev Immunol. 2022 Nov;22(11):651-652.
Wang Y, Yu M, Matsushita K, Liu C, Ishihara N, Nomura M, Tsai M, Galli SJ. Dynamin-related protein 1 differentially regulates FcεRI- and substance P-induced mast cell activation. J Allergy Clin Immunol. 2022 Nov;150(5):1228-1231.e5.
Kizer KW, Perera FP, Nadeau KC. Health implications of the West Virginia v Environmental Protection Agency US Supreme Court decision. Lancet Planet Health. 2022 Nov;6(11):e847-e848.
Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ. New Insights Into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy. Annu Rev Pathol. 2022 Oct 21.
Kabasser S, Radauer C, Eber E, Haber ME, Hieden K, Zieglmayer P, Kost LE, Sindher SB, Chinthrajah S, Geiselhart S, Hoffmann-Sommergruber K, Nadeau KC, Breiteneder H, Bublin M. Co-sensitization to the three non-homologous major cashew allergens Ana o 1, Ana o 2 and Ana o 3 is caused by IgE cross-reactivity. J Investig Allergol Clin Immunol. 2022 Oct 18:0. [Epub ahead of print].
Zhou X, Yu W, Dunham DM, Schuetz JP, Blish CA, DeKruyff RH, Nadeau KC. Cytometric analysis reveals an association between allergen-responsive natural killer cells and human peanut allergy. J Clin Invest. 2022 Oct 17;132(20):e157962.
Warren C, Sherr J, Sindher S, Nadeau KC, Casale TB, Ward D, Gupta R, Chinthrajah RS. The impact of COVID-19 on a national sample of US adults with food allergy. J Allergy Clin Immunol Pract. 2022 Oct;10(10):2744-2747.
Ram-Mohan N, Rogers AJ, Blish CA, Nadeau KC, Zudock EJ, Kim D, Quinn JV, Sun L, Liesenfeld O; Stanford COVID-19 Biobank Study Group, Yang S. Using a 29-mRNA Host Response Classifier To Detect Bacterial Coinfections and Predict Outcomes in COVID-19 Patients Presenting to the Emergency Department. Microbiol Spectr. 2022 Oct 17:e0230522.
Pelham SJ, Caldirola MS, Avery DT, Mackie J, Rao G, Gothe F, Peters TJ, Guerin A, Neumann D, Vokurkova D, Hwa V, Zhang W, Lyu SC, Chang I, Manohar M, Nadeau KC, Gaillard MI, Bezrodnik L, Iotova V, Zwirner NW, Gutierrez M, Al-Herz W, Goodnow CC, Vargas-Hernández A, Forbes Satter LR, Hambleton S, Deenick EK, Ma CS, Tangye SG. STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis. J Allergy Clin Immunol. 2022 Oct;150(4):931-946.
Turner PJ, Gretzinger M, Patel N, Brough HA, Chinthrajah RS, Ebisawa M, Elizur A, Koplin JJ, Peters RL, Purington N, Nowak-Wegrzyn A, Saf S, Sampson HA, Westerhout J, Blom WM, Baumert JL, Houben GF, Remington BC. Updated threshold dose-distribution data for sesame. Allergy. 2022 Oct;77(10):3124-3162.
Wood RA, Chinthrajah RS, Eggel A, Bottoli I, Gautier A, Woisetschlaeger M, Tassinari P, Altman P. The rationale for development of ligelizumab in food allergy. World Allergy Organ J. 2022 Sep 13;15(9):100690.
Bearer CF, Molloy EJ, Tessema MT, Pak-Gorstein S, Montecillo-Narvaez D, Darmstadt GL, Sampath V, Mulkey S, Nadeau KC. Global climate change: the defining issue of our time for our children's health. Pediatr Res. 2022 Sep 8. [Epub ahead of print].
Wolfe CR, Tomashek KM, Patterson TF, et al;ACTT-4 Study Group (includes Nadeau K). Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial. Lancet Respir Med. 2022 Sep;10(9):888-899.
Parikh VN, Ioannidis AG, Jimenez-Morales D, Gorzynski JE, De Jong HN, Liu X, Roque J, Cepeda-Espinoza VP, Osoegawa K, Hughes C, Sutton SC, Youlton N, Joshi R, Amar D, Tanigawa Y, Russo D, Wong J, Lauzon JT, Edelson J, Mas Montserrat D, Kwon Y, Rubinacci S, Delaneau O, Cappello L, Kim J, Shoura MJ, Raja AN, Watson N, Hammond N, Spiteri E, Mallempati KC, Montero-Martín G, Christle J, Kim J, Kirillova A, Seo K, Huang Y, Zhao C, Moreno-Grau S, Hershman SG, Dalton KP, Zhen J, Kamm J, Bhatt KD, Isakova A, Morri M, Ranganath T, Blish CA, Rogers AJ, Nadeau K, Yang S, Blomkalns A, O'Hara R, Neff NF, DeBoever C, Szalma S, Wheeler MT, Gates CM, Farh K, Schroth GP, Febbo P, deSouza F, Cornejo OE, Fernandez-Vina M, Kistler A, Palacios JA, Pinsky BA, Bustamante CD, Rivas MA, Ashley EA. Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy. Nat Commun. 2022 Aug 30;13(1):5107.
Dantzer JA, Kim EH, Chinthrajah RS, Wood RA. Treatment for Food Allergy: Current Status and Unmet Needs. J Allergy Clin Immunol. 2022 Aug 20:S0091-6749(22)01116-2.
Zhao X, Blokhuis BRJ, Redegeld FA, Chang I, Dunham D, Chen H, Nadeau K, Garssen J, Knippels LMJ, Hogenkamp A. Selenomethionine attenuates allergic effector responses in human primary mast cells. Allergy. 2022 Aug;77(8):2552-2555.
Jutel M, Torres MJ, Palomares O, Akdis CA, Eiwegger T, Untersmayr E, Barber D, Zemelka-Wiacek M, Kosowska A, Palmer E, Vieths S, Mahler V, Canonica WG, Nadeau K, Shamji MH, Agache I. COVID-19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals-EAACI recommendations. Allergy. 2022 Aug;77(8):2313-2336.
Sousa-Pinto B, Azevedo LF, Jutel M, Agache I, Canonica GW, Czarlewski W, Papadopoulos NG, Bergmann KC, Devillier P, Laune D, Klimek L, Anto A, Anto JM, Eklund P, Almeida R, Bedbrook A, Bosnic-Anticevich S, Brough HA, Brussino L, Cardona V, Casale T, Cecchi L, Charpin D, Chivato T, Costa EM, Cruz AA, Dramburg S, Durham SR, De Feo G, Gerth van Wijk R, Fokkens WJ, Gemicioglu B, Haahtela T, Illario M, Ivancevich JC, Kvedariene V, Kuna P, Larenas-Linnemann DE, Makris M, Mathieu-Dupas E, Melén E, Morais-Almeida M, Mösges R, Mullol J, Nadeau KC, Pham-Thi N, O'Hehir R, Regateiro FS, Reitsma S, Samolinski B, Sheikh A, Stellato C, Todo-Bom A, Tomazic PV, Toppila-Salmi S, Valero A, Valiulis A, Ventura MT, Wallace D, Waserman S, Yorgancioglu A, De Vries G, van Eerd M, Zieglmayer P, Zuberbier T, Pfaar O, Almeida Fonseca J, Bousquet J. Development and validation of combined symptom-medication scores for allergic rhinitis. Allergy. 2022 Jul;77(7):2147-2162.
Feyaerts D, Hédou J, Gillard J, Chen H, Tsai ES, Peterson LS, Ando K, Manohar M, Do E, Dhondalay GKR, Fitzpatrick J, Artandi M, Chang I, Snow TT, Chinthrajah RS, Warren CM, Wittman R, Meyerowitz JG, Ganio EA, Stelzer IA, Han X, Verdonk F, Gaudillière DK, Mukherjee N, Tsai AS, Rumer KK, Jacobsen DR, Bjornson-Hooper ZB, Jiang S, Saavedra SF, Valdés Ferrer SI, Kelly JD, Furman D, Aghaeepour N, Angst MS, Boyd SD, Pinsky BA, Nolan GP, Nadeau KC, Gaudillière B, McIlwain DR. Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19. Cell Rep Med. 2022 Jul 19;3(7):100680
Moroishi Y, Gui J, Hoen AG, Morrison HG, Baker ER, Nadeau KC, Li H, Li Z, Madan JC, Karagas MR. The relationship between the gut microbiome and the risk of respiratory infections among newborns. Commun Med (Lond). 2022 Jul 14;2:87.
Jia X, Cao S, Lee AS, Manohar M, Sindher SB, Ahuja N, Artandi M, Blish CA, Blomkalns AL, Chang I, Collins WJ, Desai M, Din HN, Do E, Fernandes A, Geng LN, Rosenberg-Hasson Y, Mahoney MR, Glascock AL, Chan LY, Fong SY; CLIAHUB Consortium; Chan Zuckerberg Biohub, Phelps M, Raeber O; Stanford COVID-19 Biobank Study Group, Purington N, Röltgen K, Rogers AJ, Snow T, Wang TT, Solis D, Vaughan L, Verghese M, Maecker H, Wittman R, Puri R, Kistler A, Yang S, Boyd SD, Pinsky BA, Chinthrajah S, Nadeau KC. Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome. JCI Insight. 2022 Jul 8;7(13):e156713.
Pongracic JA, Gagnon R, Sussman G, Siri D, Oriel RC, Brown-Whitehorn TF, Green TD, Campbell DE, Anvari S, Berger WE, Bird JA, Chan ES, Cheema A, Chinthrajah RS, Chong HJ, Dowling PJ, Fineman SM, Fleischer DM, Gonzalez-Reyes E, Kim EH, Lanser BJ, MacGinnitie A, Mehta H, Petroni D, Rupp N, Schneider LC, Scurlock AM, Sher LD, Shreffler WG, Sindher SB, Stillerman A, Wood R, Yang WH, Bois T, Sampson HA, Bégin P. Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1864-1873.e10.
Sindher SB, Fast K, Nadeau KC, Chinthrajah RS. Providing a Safe Nest for Improved Health Care Outcomes in Pregnant Women With Asthma. J Allergy Clin Immunol Pract. 2022 Jul;10(7):1784-1787.
Goshua A, Akdis CA, Nadeau KC. World Health Organization global air quality guideline recommendations: Executive summary. Allergy. 2022 Jul;77(7):1955-1960.
Sindher SB, Long A, Chin AR, Hy A, Sampath V, Nadeau KC, Chinthrajah RS. Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi-targeted approach. Allergy. 2022 Jun 22.
Perera F, Nadeau K. Climate Change, Fossil-Fuel Pollution, and Children's Health. N Engl J Med. 2022 Jun 16;386(24):2303-2314.
Yang LM, Costales C, Ramanathan M, Bulterys PL, Murugesan K, Schroers-Martin J, Alizadeh AA, Boyd SD, Brown JM, Nadeau KC, Nadimpalli SS, Wang AX, Busque S, Pinsky BA, Banaei N. Cellular and humoral immune response to SARS-CoV-2 vaccination and booster dose in immunosuppressed patients: An observational cohort study. J Clin Virol. 2022 Jun 11;153:105217.
Yoon J, Kizer KW, Ong MK, Zhang Y, Vanneman ME, Chow A, Phibbs CS. Health Care Access Expansions and Use of Veterans Affairs and Other Hospitals by Veterans. JAMA Health Forum. 2022 Jun 10;3(6):e221409.
Chinthrajah RS, Jones SM, Kim EH, Sicherer SH, Shreffler W, Lanser BJ, Atri N, Babineau DC, Adelman DC, Iqbal A, Limb SL, Rudman Spergel AK, Togias A, Wood RA. Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy. J Allergy Clin Immunol. 2022 Jun;149(6):2166-2170.e1.
Valent P, Akin C, Hartmann K, Reiter A, Gotlib J, Sotlar K, Sperr WR, Degenfeld-Schonburg L, Smiljkovic D, Triggiani M, Horny HP, Arock M, Galli SJ, Metcalfe DD. Drug-induced mast cell eradication: A novel approach to treat mast cell activation disorders? J Allergy Clin Immunol. 2022 Jun;149(6):1866-1874.
Yoon J, Kizer KW, Ong MK, Zhang Y, Vanneman ME, Chow A, Phibbs CS. Health Care Access Expansions and Use of Veterans Affairs and Other Hospitals by Veterans. JAMA Health Forum. 2022 Jun 10;3(6):e221409. Tsai M, Valent P, Galli SJ. KIT as a master regulator of the mast cell lineage. J Allergy Clin Immunol. 2022 Jun;149(6):1845-1854.
Sindher SB, Kumar D, Cao S, Purington N, Long A, Sampath V, Zedeck SS, Woch MA, Garcia-Lloret M, Chinthrajah RS. Phase 2, randomized multi oral immunotherapy with omalizumab 'real life' study. Allergy. 2022 Jun;77(6):1873-1884.
O'Rourke E, Tang H, Chin A, Long A, Sindher S, Chinthrajah RS. Current insights: a systemic review of therapeutic options for peanut allergy. Curr Opin Allergy Clin Immunol. 2022 Jun 1;22(3):188-193.
Chang AY, Tan AX, Nadeau KC, Odden MC. Aging Hearts in a Hotter, More Turbulent World: The Impacts of Climate Change on the Cardiovascular Health of Older Adults. Curr Cardiol Rep. 2022 Jun;24(6):749-760.
Castaño N, Kim S, Martin AM, Galli SJ, Nadeau KC, Tang SKY. Exponential magnetophoretic gradient for the direct isolation of basophils from whole blood in a microfluidic system. Lab Chip. 2022 May 3;22(9):1690-1701.
Agache I, Sampath V, Aguilera J, Akdis CA, Akdis M, Barry M, Bouagnon A, Chinthrajah S, Collins W, Dulitzki C, Erny B, Gomez J, Goshua A, Jutel M, Kizer KW, Kline O, LaBeaud AD, Pali-Schöll I, Perrett KP, Peters RL, Plaza MP, Prunicki M, Sack T, Salas RN, Sindher SB, Sokolow SH, Thiel C, Veidis E, Wray BD, Traidl-Hoffmann C, Witt C, Nadeau KC. Climate change and global health: A call to more research and more action. Allergy. 2022 May;77(5):1389-1407.
Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, Altiner S, Ozbey U, Ogulur I, Mitamura Y, Yilmaz I, Nadeau K, Ozdemir C, Mungan D, Akdis CA. Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease. Allergy. 2022 May;77(5):1418-1449.
Zhang W, Dhondalay GK, Liu TA, Kaushik A, Hoh R, Kwok S, Kambham N, Fernandez-Becker NQ, Andorf S, Desai M, Galli SJ, Boyd SD, Nadeau KC, Manohar M, DeKruyff RH, Chinthrajah RS. Gastrointestinal γδ T cells reveal differentially expressed transcripts and enriched pathways during peanut oral immunotherapy. Allergy. 2022 May;77(5):1606-1610.
Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science. 2022 Apr 15;376(6590):eabi9591.
Vivanco Gonzalez N, Oliveria JP, Tebaykin D, Ivison GT, Mukai K, Tsai MM, Borges L, Nadeau KC, Galli SJ, Tsai AG, Bendall SC. An optimized protocol for phenotyping human granulocytes by mass cytometry. STAR Protoc. 2022 Apr 8;3(2):101280.
Nadeau KC, Agache I, Jutel M, Annesi Maesano I, Akdis M, Sampath V, D'Amato G, Cecchi L, Traidl-Hoffmann C, Akdis CA. Climate change: A call to action for the United Nations. Allergy. 2022 Apr;77(4):1087-1090.
Jansen K, Satitsuksanoa P, Wirz OF, Schneider SR, van de Veen W, Tan G, Sokolowska M, Message SD, Kebadze T, Glanville N, Mallia P, Akdis CA, Moniuszko M, Johnston SL, Nadeau K, Akdis M. T regulatory cells from atopic asthmatic individuals show a Th2-like phenotype. Allergy. 2022 Apr;77(4):1320-1324.
Li C, Lee A, Grigoryan L, Arunachalam PS, Scott MKD, Trisal M, Wimmers F, Sanyal M, Weidenbacher PA, Feng Y, Adamska JZ, Valore E, Wang Y, Verma R, Reis N, Dunham D, O'Hara R, Park H, Luo W, Gitlin AD, Kim P, Khatri P, Nadeau KC, Pulendran B. Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine. Nat Immunol. 2022 Apr;23(4):543-555.
Gao YD, Agache I, Akdis M, Nadeau K, Klimek L, Jutel M, Akdis CA. The effect of allergy and asthma as a comorbidity on the susceptibility and outcomes of COVID-19. Int Immunol. 2022 Mar 25;34(4):177-188.
Röltgen K, Nielsen SCA, Silva O, Younes SF, Zaslavsky M, Costales C, Yang F, Wirz OF, Solis D, Hoh RA, Wang A, Arunachalam PS, Colburg D, Zhao S, Haraguchi E, Lee AS, Shah MM, Manohar M, Chang I, Gao F, Mallajosyula V, Li C, Liu J, Shoura MJ, Sindher SB, Parsons E, Dashdorj NJ, Dashdorj ND, Monroe R, Serrano GE, Beach TG, Chinthrajah RS, Charville GW, Wilbur JL, Wohlstadter JN, Davis MM, Pulendran B, Troxell ML, Sigal GB, Natkunam Y, Pinsky BA, Nadeau KC, Boyd SD. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination. Cell. 2022 Mar 17;185(6):1025-1040.e14.
Moroishi Y, Signes-Pastor AJ, Li Z, Cottingham KL, Jackson BP, Punshon T, Madan J, Nadeau K, Gui J, Karagas MR. Infant infections, respiratory symptoms, and allergy in relation to timing of rice cereal introduction in a United States cohort. Sci Rep. 2022 Mar 15;12(1):4450.
Aguilera J, Han X, Cao S, Balmes J, Lurmann F, Tyner T, Lutzker L, Noth E, Hammond SK, Sampath V, Burt T, Utz PJ, Khatri P, Aghaeepour N, Maecker H, Prunicki M, Nadeau K. Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ. Clin Epigenetics. 2022 Mar 14;14(1):40.
Chakraborty S, Gonzalez JC, Sievers BL, Mallajosyula V, Chakraborty S, Dubey M, Ashraf U, Cheng BY, Kathale N, Tran KQT, Scallan C, Sinnott A, Cassidy A, Chen ST, Gelbart T, Gao F, Golan Y, Ji X, Kim-Schulze S, Prahl M, Gaw SL, Gnjatic S, Marron TU, Merad M, Arunachalam PS, Boyd SD, Davis MM, Holubar M, Khosla C, Maecker HT, Maldonado Y, Mellins ED, Nadeau KC, Pulendran B, Singh U, Subramanian A, Utz PJ, Sherwood R, Zhang S, Jagannathan P, Tan GS, Wang TT. Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity. Sci Transl Med. 2022 Mar 9;14(635):eabm7853
Sievers BL, Chakraborty S, Xue Y, Gelbart T, Gonzalez JC, Cassidy AG, Golan Y, Prahl M, Gaw SL, Arunachalam PS, Blish CA, Boyd SD, Davis MM, Jagannathan P, Nadeau KC, Pulendran B, Singh U, Scheuermann RH, Frieman MB, Vashee S, Wang TT, Tan GS. Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses. Sci Transl Med. 2022 Mar 2;14(634):eabn7842
Chang X, March M, Mentch F, Nguyen K, Glessner J, Qu H, Liu Y, Furuta G, Aceves S, Gonsalves N, Nadeau K, Cianferoni A, Spergel J, Sleiman P, Hakonarson H. A genome-wide association meta-analysis identifies new eosinophilic esophagitis loci. J Allergy Clin Immunol. 2022 Mar;149(3):988-998.
Baker MC, Mallajosyula V, Davis MM, Boyd SD, Nadeau KC, Robinson WH. Effective viral vector response to SARS-CoV-2 booster vaccination in a patient with rheumatoid arthritis after initial ineffective response to messenger RNA vaccine. Arthritis Rheumatol. 2022 Mar;74(3):541-542.
Herrmann A, Lenzer B, Müller BS, Danquah I, Nadeau KC, Muche-Borowski C, Traidl-Hoffmann C. Integrating planetary health into clinical guidelines to sustainably transform health care. Lancet Planet Health. 2022 Mar;6(3):e184-e185.
Kizer KW, Nadeau KC. Confronting Health Care's Climate Crisis Conundrum: The Federal Government as Catalyst for Change. JAMA. 2022 Feb 22;327(8):715-716.
Wanet A, Bassal MA, Patel SB, Marchi F, Mariani SA, Ahmed N, Zhang H, Borchiellini M, Chen S, Zhang J, Di Ruscio A, Miyake K, Tsai M, Paranjape A, Park SY, Karasuyama H, Schroeder T, Dzierzak E, Galli SJ, Tenen DG, Welner RS. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021 Feb 5;6(56):eaba0178.
Quake AZ, Liu TA, D'Souza R, Jackson KG, Woch M, Tetteh A, Sampath V, Nadeau KC, Sindher S, Chinthrajah RS, Cao S. Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study. Nutrients.2022 Feb 9;14(4).
Lunjani N, Tan G, Dreher A, Sokolowska M, Groeger D, Warwyzniak M, Altunbulakli C, Westermann P, Basera W, Hobane L, Botha M, Gray C, Mankahla A, Gray C, Nadeau KC, Hlela C, Levin M, O'Mahony L, Akdis CA. Environment-dependent alterations of immune mediators in urban and rural South African children with atopic dermatitis. Allergy. 2022 Feb;77(2):569-581.
Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, Chan SM, Santos AF, Bahnson HT, Guttman-Yassky E, Gupta RS, Lack G, Ciaccio CE, Sampath V, Nadeau KC, Nagler CR. Early intervention and prevention of allergic diseases. Allergy. 2022 Feb;77(2):416-441.
Ram-Mohan N, Kim D, Rogers AJ, Blish CA, Nadeau KC, Blomkalns AL, Yang S. Association Between SARS-CoV-2 RNAemia and Postacute Sequelae of COVID-19. Open Forum Infect Dis. 2022 Feb;9(2):ofab646.
Ram-Mohan N, Kim D, Zudock EJ, Hashemi MM, Tjandra KC, Rogers AJ, Blish CA, Nadeau KC, Newberry JA, Quinn JV, O'Hara R, Ashley E, Nguyen H, Jiang L, Hung P, Blomkalns AL, Yang S. SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19. Clin Infect Dis. 2022 Jan 29;74(2):218-226.
Jones SM, Kim EH, Nadeau KC, Nowak-Wegrzyn A, Wood RA, Sampson HA, Scurlock AM, Chinthrajah S, Wang J, Pesek RD, Sindher SB, Kulis M, Johnson J, Spain K, Babineau DC, Chin H, Laurienzo-Panza J, Yan R, Larson D, Qin T, Whitehouse D, Sever ML, Sanda S, Plaut M, Wheatley LM, Burks AW; Immune Tolerance Network. Efficacy and safety of oral immunotherapy in children aged 1-3 years with peanut allergy (the Immune Tolerance Network trial): a randomised placebo-controlled study. Lancet. 2022 Jan 22;399(10322):359-371.
Alonzi S, Caruso TJ, Sindher SB, Cao S, Varadharajulu S, Collins WJ, Chinthrajah RS. Virtual Reality Reduces Pediatric Anxiety During Food Allergy Clinical Trials: A Pilot Randomized, Pragmatic Study. Front Allergy. 2022 Jan 13;2:779804.
Suthar MS, Arunachalam PS, Hu M, Reis N, Trisal M, Raeber O, Chinthrajah S, Davis-Gardner ME, Manning K, Mudvari P, Boritz E, Godbole S, Henry AR, Douek DC, Halfmann P, Kawaoka Y, Boyd SD, Davis MM, Zarnitsyna VI, Nadeau K, Pulendran B. Durability of immune responses to the BNT162b2 mRNA vaccine. Med (N Y). 2022 Jan 14;3(1):25-27.
Chinthrajah S, Garcia E, Hasan Z, Hy A, Wong L. Climate Change Health Effects and What You Can Do. Am J Respir Crit Care Med. 2022 Jan 1;205(1):P1-P2.
Manohar M, Nadeau KC, Kasowski M. Early peanut introduction wins over the HLA-DQA1*01:02 allele in the interplay between environment and genetics. J Clin Invest. 2022 Jan 4;132(1)Eggert LE, He Z, Collins W, Lee AS, Dhondalay G, Jiang SY, Fitzpatrick J, Snow TT, Pinsky BA, Artandi M, Barman L, Puri R, Wittman R, Ahuja N, Blomkalns A, O'Hara R, Cao S, Desai M, Sindher SB, Nadeau K, Chinthrajah RS. Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19. Allergy. 2022 Jan;77(1):173-185.
Eggert LE, He Z, Collins W, Lee AS, Dhondalay G, Jiang SY, Fitzpatrick J, Snow TT, Pinsky BA, Artandi M, Barman L, Puri R, Wittman R, Ahuja N, Blomkalns A, O'Hara R, Cao S, Desai M, Sindher SB, Nadeau K, Chinthrajah RS. Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19. Allergy. 2022 Jan;77(1):173-185.
Wirz OF, Jansen K, Satitsuksanoa P, van de Veen W, Tan G, Sokolowska M, Mirer D, Stanić B, Message SD, Kebadze T, Glanville N, Mallia P, Gern JE, Papadopoulos N, Akdis CA, Johnston SL, Nadeau K, Akdis M. Experimental rhinovirus infection induces an antiviral response in circulating B cells which is dysregulated in patients with asthma. Allergy. 2022 Jan;77(1):130-142.
Nguyen DI, Sindher SB, Chinthrajah RS, Nadeau K, Davis CM. Shrimp-allergic patients in a multi-food oral immunotherapy trial. Pediatr Allergy Immunol. 2022 Jan;33(1):e13679.
Perrett KP, Sindher SB, Begin P, Shanks J, Elizur A. Advances, Practical Implementation, and Unmet Needs Regarding Oral Immunotherapy for Food Allergy. J Allergy Clin Immunol Pract. 2022 Jan;10(1):19-33.
Turner PJ, Patel N, Ballmer-Weber BK, Baumert JL, Blom WM, Brooke-Taylor S, Brough H, Campbell DE, Chen H, Chinthrajah RS, Crevel RWR, Dubois AEJ, Ebisawa M, Elizur A, Gerdts JD, Gowland MH, Houben GF, Hourihane JOB, Knulst AC, La Vieille S, López MC, Mills ENC, Polenta GA, Purington N, Said M, Sampson HA, Schnadt S, Södergren E, Taylor SL, Remington BC. Peanut Can Be Used as a Reference Allergen for Hazard Characterization in Food Allergen Risk Management: A Rapid Evidence Assessment and Meta-Analysis. J Allergy Clin Immunol Pract. 2022 Jan;10(1):59-70.
Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, IMPACC study group. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. eBioMedicine. 2022;83:104208.

2021 Publications

Anderson B, Wong L, Adlou B, Long A, Chinthrajah RS. Oral Immunotherapy in Children: Clinical Considerations and Practical Management. J Asthma Allergy. 2021 Dec 14;14:1497-1510.
Dashdorj NJ, Wirz OF, Röltgen K, Haraguchi E, Buzzanco AS 3rd, Sibai M, Wang H, Miller JA, Solis D, Sahoo MK, Arunachalam PS, Lee AS, Shah MM, Liu J, Byambabaatar S, Bat-Ulzii P, Enkhbat A, Batbold E, Zulkhuu D, Ochirsum B, Khurelsukh T, Dalantai G, Burged N, Baatarsuren U, Ariungerel N, Oidovsambuu O, Bungert AS, Genden Z, Yagaanbuyant D, Mordorj A, Pulendran B, Chinthrajah S, Nadeau KC, Jardetzky T, Wilbur JL, Wohlstadter JN, Sigal GB, Pinsky BA, Boyd SD, Dashdorj ND. Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia. Cell Host Microbe. 2021 Dec 8;29(12):1738-1743.e4.
Jansen K, Satitsuksanoa P, Wirz OF, Schneider SR, van de Veen W, Tan G, Sokolowska M, Message SD, Kebadze T, Glanville N, Pennington LF, Gasser P, Kleinboelting S, Zhang C, Skiniotis G, Eggel A, Jardetzky TS. Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun. 2021 Dec 3;12(1):7069.
Pennington LF, Gasser P, Kleinboelting S, Zhang C, Skiniotis G, Eggel A, Jardetzky TS. Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun. 2021 Dec 3;12(1):7069.
Jiang SY, Smith EM, Vo V, Akdis C, Nadeau KC. Non-immunoglobulin E-mediated allergy associated with Pfizer-BioNTech coronavirus disease 2019 vaccine excipient polyethylene glycol. Ann Allergy Asthma Immunol. 2021 Dec;127(6):694-696.
Pawankar R, Castells M, Akdis M, Nadeau K, Leung ASY. Women in science and medicine. Allergy. 2021 Dec;76(12):3578-3580.
Suárez-Fariñas M, Suprun M, Kearney P, Getts R, Grishina G, Hayward C, Luta D, Porter A, Witmer M, du Toit G, Lack G, Chinthrajah RS, Galli SJ, Nadeau K, Sampson HA. Accurate and reproducible diagnosis of peanut allergy using epitope mapping. Allergy. 2021 Dec;76(12):3789-3797.
Jiang SY, Smith EM, Vo V, Akdis C, Nadeau KC. Non-immunoglobulin E-mediated allergy associated with Pfizer-BioNTech coronavirus disease 2019 vaccine excipient polyethylene glycol. Ann Allergy Asthma Immunol. 2021 Dec;127(6):694-696.
Sampath V, Abrams EM, Adlou B, Akdis C, Akdis M, Brough HA, Chan S, Chatchatee P, Chinthrajah RS, Cocco RR, Deschildre A, Eigenmann P, Galvan C, Gupta R, Hossny E, Koplin JJ, Lack G, Levin M, Shek LP, Makela M, Mendoza-Hernandez D, Muraro A, Papadopoulous NG, Pawankar R, Perrett KP, Roberts G, Sackesen C, Sampson H, Tang MLK, Togias A, Venter C, Warren CM, Wheatley LM, Wong GWK, Beyer K, Nadeau KC, Renz H. Food allergy across the globe. J Allergy Clin Immunol. 2021 Dec;148(6):1347-1364.
Cauwenberghs N, Prunicki M, Sabovčik F, Perelman D, Contrepois K, Li X, Snyder MP, Nadeau KC, Kuznetsova T, Haddad F, Gardner CD. Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic. Am J Clin Nutr.2021 Nov 8;114(5):1655-1665.
Bae HR, Chandy M, Aguilera J, Smith EM, Nadeau KC, Wu JC, Paik DT. Adverse effects of air pollution-derived fine particulate matter on cardiovascular homeostasis and disease. Trends Cardiovasc Med. 2022 Nov;32(8):487-498.
Chen G, Shrock EL, Li MZ, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Phipatanakul W, Schneider L, Oettgen HC, Elledge SJ. High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy. Cell Rep Med. 2021 Oct 19;2(10):100410.
Valent P, Akin C, Hartmann K, Alvarez-Twose I, Brockow K, Hermine O, Niedoszytko M, Schwaab J, Lyons JJ, Carter MC, Elberink HO, Butterfield JH, George TI, Greiner G, Ustun C, Bonadonna P, Sotlar K, Nilsson G, Jawhar M, Siebenhaar F, Broesby-Olsen S, Yavuz S, Zanotti R, Lange M, Nedoszytko B, Hoermann G, Castells M, Radia DH, Muñoz-Gonzalez JI, Sperr WR, Triggiani M, Kluin-Nelemans HC, Galli SJ, Schwartz LB, Reiter A, Orfao A, Gotlib J, Arock M, Horny HP, Metcalfe DD. Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal. Hemasphere. 2021 Oct 13;5(11):e646.
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021 Oct 4;218(10):e20201466.
Cao S, Borro M, Alonzi S, Sindher S, Nadeau K, Chinthrajah RS. Improvement in Health-Related Quality of Life in Food-Allergic Patients: A Meta-Analysis. J Allergy Clin Immunol Pract. 2021 Oct;9(10):3705-3714.
Pennington LF, Gasser P, Brigger D, Guntern P, Eggel A, Jardetzky TS. Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J Allergy Clin Immunol. 2021 Oct;148(4):1049-1060.
Movassagh H, Halchenko Y, Sampath V, Nygaard UC, Jackson B, Robbins D, Li Z, Nadeau KC, Karagas MR. Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures. Environ Res. 2021 Oct;201:111385.
Jansen K, Wirz OF, van de Veen W, Tan G, Mirer D, Sokolowska M, Satitsuksanoa P, Message SD, Kebadze T, Glanville N, Mallia P, Skiepko R, Eljaszewicz A, Moniuszko M, Cardoso C, Gern JE, Papadopoulos NG, Akdis CA, Johnston SL, Nadeau KC, Akdis M. Loss of regulatory capacity in Treg cells following rhinovirus infection. J Allergy Clin Immunol. 2021 Oct;148(4):1016-1029.e16.
Nguyen KD, Wirz OF, Röltgen K, Pandey S, Tolentino L, Boyd SD, Pham TD. Efficient Identification of High-Titer Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Plasma Samples by Pooling Method. Arch Pathol Lab Med. 2021 Oct 1;145(10):1221-1227.
Sanghi A, Gruber JJ, Metwally A, Jiang L, Reynolds W, Sunwoo J, Orloff L, Chang HY, Kasowski M, Snyder MP. Chromatin accessibility associates with protein-RNA correlation in human cancer. Nat Commun. 2021 Sep 30;12(1):5732.
Chang SE, Feng A, Meng W, Apostolidis SA, Mack E, Artandi M, Barman L, Bennett K, Chakraborty S, Chang I, Cheung P, Chinthrajah S, Dhingra S, Do E, Finck A, Gaano A, Geßner R, Giannini HM, Gonzalez J, Greib S, Gündisch M, Hsu AR, Kuo A, Manohar M, Mao R, Neeli I, Neubauer A, Oniyide O, Powell AE, Puri R, Renz H, Schapiro J, Weidenbacher PA, Wittman R, Ahuja N, Chung HR, Jagannathan P, James JA, Kim PS, Meyer NJ, Nadeau KC, Radic M, Robinson WH, Singh U, Wang TT, Wherry EJ, Skevaki C, Luning Prak ET, Utz PJ. New-onset IgG autoantibodies in hospitalized patients with COVID-19. Nat Commun. 2021 Sep 14;12(1):5417.
Wirz OF, Röltgen K, Stevens BA, Pandey S, Sahoo MK, Tolentino L, Verghese M, Nguyen K, Hunter M, Snow TT, Singh AR, Blish CA, Cochran JR, Zehnder JL, Nadeau KC, Pinsky BA, Pham TD, Boyd SD. Use of Outpatient-Derived COVID-19 Convalescent Plasma in COVID-19 Patients Before Seroconversion. Front Immunol. 2021 Sep 14;12:739037.
Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A; Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J. RNA splicing programs define tissue compartments and cell types at single-cell resolution. Elife. 2021 Sep 13;10:e70692.
Nygaard UC, Xiao L, Nadeau KC, Hew KM, Lv N, Camargo CA, Strub P, Ma J. Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma. Am J Clin Nutr. 2021 Sep 1;114(3):1012-1027.
Warren CM, Snow TT, Lee AS, Shah MM, Heider A, Blomkalns A, Betts B, Buzzanco AS, Gonzalez J, Chinthrajah RS, Do E, Chang I, Dunham D, Lee G, O'Hara R, Park H, Shamji MH, Schilling L, Sindher SB, Sisodiya D, Smith E, Tsai M, Galli SJ, Akdis C, Nadeau KC. Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System. JAMA Netw Open. 2021 Sep 1;4(9):e2125524.
Manohar M, Dunham D, Gupta S, Yan Z, Zhang W, Minnicozzi S, Kirkey M, Bunning B, Roy Chowdhury R, Galli SJ, Boyd SD, Kost LE, Chinthrajah RS, Desai M, Oettgen HC, Maecker HT, Yu W, DeKruyff RH, Andorf S, Nadeau KC. Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. Allergy. 2021 Sep;76(9):2809-2826.
Purington N, Andorf S, Bunning B, Chinthrajah S, Nadeau K, Desai M. Novel application of a discrete time-to-event model for randomized oral immunotherapy clinical trials with repeat food challenges. Stat Med. 2021 Aug 15;40(18):4136-4149.
Agarwal P, Kaushik A, Sarkar S, Rao D, Mukherjee N, Bharat V, Das S, Saha AK. Global survey-based assessment of lifestyle changes during the COVID-19 pandemic. PLoS One. 2021 Aug 13;16(8):e0255399.
Wilk AJ, Lee MJ, Wei B, Parks B, Pi R, Martínez-Colón GJ, Ranganath T, Zhao NQ, Taylor S, Becker W, Jimenez-Morales D, Blomkalns AL, O'Hara R, Ashley EA, Nadeau KC, Yang S, Holmes S, Rabinovitch M, Rogers AJ, Greenleaf WJ, Blish CA. Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19. J Exp Med. 2021 Aug 2;218(8)
Leung DYM, Elias PM, Nadeau KC, Berdyshev E. Olive oil is for eating and not skin moisturization. J Allergy Clin Immunol. 2021 Aug;148(2):652.
Arunachalam PS, Scott MKD, Hagan T, Li C, Feng Y, Wimmers F, Grigoryan L, Trisal M, Edara VV, Lai L, Chang SE, Feng A, Dhingra S, Shah M, Lee AS, Chinthrajah S, Sindher SB, Mallajosyula V, Gao F, Sigal N, Kowli S, Gupta S, Pellegrini K, Tharp G, Maysel-Auslender S, Hamilton S, Aoued H, Hrusovsky K, Roskey M, Bosinger SE, Maecker HT, Boyd SD, Davis MM, Utz PJ, Suthar MS, Khatri P, Nadeau KC, Pulendran B. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature. 2021 Aug;596(7872):410-416.
Röltgen K, Boyd SD. Antibody and B cell responses to SARS-CoV-2 infection and vaccination. Cell Host Microbe. 2021 Jul 14;29(7):1063-1075.
Zhou X, Yu W, Lyu SC, Macaubas C, Bunning B, He Z, Mellins ED, Nadeau KC. A positive feedback loop reinforces the allergic immune response in human peanut allergy. J Exp Med. 2021 Jul 5;218(7):e20201793.
Sahiner UM, Layhadi JA, Golebski K, István Komlósi Z, Peng Y, Sekerel B, Durham SR, Brough H, Morita H, Akdis M, Turner P, Nadeau K, Spits H, Akdis C, Shamji MH. Innate lymphoid cells: The missing part of a puzzle in food allergy. Allergy. 2021 Jul;76(7):2002-2016.
Halken S, Muraro A, de Silva D, Khaleva E, Angier E, Arasi S, Arshad H, Bahnson HT, Beyer K, Boyle R, du Toit G, Ebisawa M, Eigenmann P, Grimshaw K, Hoest A, Jones C, Lack G, Nadeau K, O'Mahony L, Szajewska H, Venter C, Verhasselt V, Wong GWK, Roberts G. EAACI guideline: Preventing the development of food allergy in infants and young children (2020 update). Pediatr Allergy Immunol.2021 Jul;32(5):843-858.
Nadeau KC. Allergen-specific IgG Antibodies for Cat Allergy?. Am J Respir Crit Care Med. 2021 Jul 1;204(1):1-2.
Mallajosyula V, Ganjavi C, Chakraborty S, McSween AM, Pavlovitch-Bedzyk AJ, Wilhelmy J, Nau A, Manohar M, Nadeau KC, Davis MM. CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients. Sci Immunol. 2021 Jul 1;6(61).
Wang Y, Matsushita K, Jackson J, Numata T, Zhang Y, Zhou G, Tsai M, Galli SJ. Transcriptome programming of IL-3-dependent bone marrow-derived cultured mast cells by stem cell factor (SCF). Allergy. 2021 Jul;76(7):2288-2291
Matsushita K, Li X, Nakamura Y, Dong D, Mukai K, Tsai M, Montgomery SB, Galli SJ. The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice. JCI Insight. 2021 Jun 22;6(12):e146572.
Paudel B, Chu T, Chen M, Sampath V, Prunicki M, Nadeau KC. Increased duration of pollen and mold exposure are linked to climate change. Sci Rep. 2021 Jun 17;11(1):12816.
Sampath V, Rabinowitz G, Shah M, Jain S, Diamant Z, Jesenak M, Rabin R, Vieths S, Agache I, Akdis M, Barber D, Breiteneder H, Chinthrajah S, Chivato T, Collins W, Eiwegger T, Fast K, Fokkens W, O'Hehir RE, Ollert M, O'Mahony L, Palomares O, Pfaar O, Riggioni C, Shamji MH, Sokolowska M, Jose Torres M, Traidl-Hoffmann C, van Zelm M, Wang Y, Zhang L, Akdis CA, Nadeau KC. Vaccines and allergic reactions: The past, the current COVID-19 pandemic, and future perspectives. Allergy. 2021 Jun;76(6):1640-1660.
Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Cao S, Tupa D, Zhang W, Sindher SB, Rank MA, Kita H, Katzka DA, Shim KP, Bunning BJ, Doyle AD, Jacobsen EA, Tsai M, Boyd SD, Manohar M, Chinthrajah RS. Gastrointestinal Eosinophil Responses in a Longitudinal, Randomized Trial of Peanut Oral Immunotherapy. Clin Gastroenterol Hepatol. 2021 Jun;19(6):1151-1159.e14.
Duan L, Celik A, Hoang JA, Schmidthaler K, So D, Yin X, Ditlof CM, Ponce M, Upton JEM, Lee JS, Hung L, Breiteneder H, Palladino C, Atkinson AR, Kim VHD, Berenjy A, Asper M, Hummel D, Wong S, Alexanian-Farr M, Magder A, Chinthrajah SR, Mukai K, Tsai M, Nadeau K, Galli SJ, Ramani AK, Szepfalusi Z, Eiwegger T. Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study. Allergy. 2021 Jun;76(6):1800-1812.
Wawrzyniak P, Krawczyk K, Acharya S, Tan G, Wawrzyniak M, Karouzakis E, Dreher A, Jakiela B, Altunbulakli C, Sanak M, O'Mahony L, Nadeau K, Akdis CA. Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma. Allergy. 2021 Jun;76(6):1864-1868.
Sokolowska M, Eiwegger T, Ollert M, Torres MJ, Barber D, Del Giacco S, Jutel M, Nadeau KC, Palomares O, Rabin RL, Riggioni C, Vieths S, Agache I, Shamji MH. EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines. Allergy. 2021 Jun;76(6):1629-1639.
Patel N, Adelman DC, Anagnostou K, Baumert JL, Blom WM, Campbell DE, Chinthrajah RS, Mills ENC, Javed B, Purington N, Remington BC, Sampson HA, Smith AD, Yarham RAR, Turner PJ. Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis. J Allergy Clin Immunol. 2021 Jun;147(6):2249-2262.e7.
Warren C, Dyer A, Lombard L, Dunn-Galvin A, Gupta R. The Psychosocial Burden of Food Allergy Among Adults: A US Population-Based Study. J Allergy Clin Immunol Pract. 2021 Jun;9(6):2452-2460.e3.
Satitsuksanoa P, Daanje M, Akdis M, Boyd SD, van de Veen W. Biology and dynamics of B cells in the context of IgE-mediated food allergy. Allergy. 2021 Jun;76(6):1707-1717.
Patel N, Adelman DC, Anagnostou K, Baumert JL, Blom WM, Campbell DE, Chinthrajah RS, Mills ENC, Javed B, Purington N, Remington BC, Sampson HA, Smith AD, Yarham RAR, Turner PJ. Using data from food challenges to inform management of consumers with food allergy: A systematic review with individual participant data meta-analysis. J Allergy Clin Immunol. 2021 Jun;147(6):2249-2262.e7.
Warren C, Lei D, Sicherer S, Schleimer R, Gupta R. Prevalence and characteristics of peanut allergy in US adults. J Allergy Clin Immunol. 2021 Jun;147(6):2263-2270.e5.
Hedlin H, Garcia A, Weng Y, He Z, Sundaram V, Bunning B, Balasubramanian V, Cunanan K, Kapphahn K, Gummidipundi S, Purington N, Boulos M, Desai M. Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape. Clin Trials. 2021 Jun;18(3):324-334.
Kaushik A, Dunham D, He Z, Manohar M, Desai M, Nadeau KC, Andorf S. CyAnno: A semi-automated approach for cell type annotation of mass cytometry datasets. Bioinformatics. 2021 May 25;37(22):4164–71.
Yang F, Nielsen SCA, Hoh RA, Röltgen K, Wirz OF, Haraguchi E, Jean GH, Lee JY, Pham TD, Jackson KJL, Roskin KM, Liu Y, Nguyen K, Ohgami RS, Osborne EM, Nadeau KC, Niemann CU, Parsonnet J, Boyd SD. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues. Science. 2021 May 14;372(6543):738-741.
Kabasser S, Hafner C, Chinthrajah S, Sindher SB, Kumar D, Kost LE, Long AJ, Nadeau KC, Breiteneder H, Bublin M. Identification of Pru du 6 as a potential marker allergen for almond allergy. Allergy.2021 May;76(5):1463-1472.
Remme RP, Frumkin H, Guerry AD, King AC, Mandle L, Sarabu C, Bratman GN, Giles-Corti B, Hamel P, Han B, Hicks JL, James P, Lawler JJ, Lindahl T, Liu H, Lu Y, Oosterbroek B, Paudel B, Sallis JF, Schipperijn J, Sosič R, de Vries S, Wheeler BW, Wood SA, Wu T, Daily GC. An ecosystem service perspective on urban nature, physical activity, and health. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2018472118.
Sibai M, Solis D, Röltgen K, Stevens BA, Mfuh KO, Sahoo MK, Shi RZ, Zehnder J, Boyd SD, Pinsky BA. Evaluation of SARS-CoV-2 total antibody detection via a lateral flow nanoparticle fluorescence immunoassay. J Clin Virol. 2021 Jun;139:104818.
Neeland MR, Tursi AR, Perrett KP, Saffery R, Koplin JJ, Nadeau KC, Andorf S. Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food-allergic infants. Pediatr Allergy Immunol. 2021 May;32(4):771-775.
Haber LT, Reichard JF, Henning AK, Dawson P, Chinthrajah RS, Sindher SB, Long A, Vincent MJ, Nadeau KC, Allen BC. Bayesian Hierarchical Evaluation of Dose-Response for Peanut Allergy in Clinical Trial Screening. Food and Chemical Toxicology. 2021 May;151:112125.
Yin Q, Yu W, Grzeskowiak CL, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, von Boehmer L, Metzner TJ, Leppert JT, Chien YH, Kuo CJ, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2016168118.
Warren CM, Brewer AG, Grobman B, Jiang J, Gupta RS. Racial/Ethnic Differences in Food Allergy. Immunol Allergy Clin North Am. 2021 May;41(2):189-203.
Krempski JW, Warren C, Han X, Zhang W, He Z, Lejeune S, Nadeau K. Food Allergies: An Example of Translational Research. Immunol Allergy Clin North Am. 2021 May;41(2):143-163.
Truong TT, Ryutov A, Pandey U, Yee R, Goldberg L, Bhojwani D, Aguayo-Hiraldo P, Pinsky BA, Pekosz A, Shen L, Boyd SD, Wirz OF, Röltgen K, Bootwalla M, Maglinte DT, Ostrow D, Ruble D, Han JH, Biegel JA, Li M, Huang C, Sahoo MK, Pannaraj PS, O'Gorman M, Judkins AR, Gai X, Dien Bard J. Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series. EBioMedicine. 2021 May;67:103355
Delaveris CS, Wilk AJ, Riley NM, Stark JC, Yang SS, Rogers AJ, Ranganath T, Nadeau KC; Stanford COVID-19 Biobank, Blish CA, Bertozzi CR. Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19. ACS Cent Sci. 2021 Apr 28;7(4):650-657.
Rosas IO, Bräu N, Waters M, Go RC, Hunter BD, Bhagani S, Skiest D, Aziz MS, Cooper N, Douglas IS, Savic S, Youngstein T, Del Sorbo L, Cubillo Gracian A, De La Zerda DJ, Ustianowski A, Bao M, Dimonaco S, Graham E, Matharu B, Spotswood H, Tsai L, Malhotra A. Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia. N Engl J Med. 2021 Apr 22;384(16):1503-1516. (Nadeau KC listed under Study team members)
Borro M, Negrini S, Long A, Chinthrajah S, Murdaca G. H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far? Clin Mol Allergy. 2021 Apr 13;19(1):4.
Camiolo MJ, Zhou X, Oriss TB, Yan Q, Gorry M, Horne W, Trudeau JB, Scholl K, Chen W, Kolls JK, Ray P, Weisel FJ, Weisel NM, Aghaeepour N, Nadeau K, Wenzel SE, Ray A. High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status. Cell Rep. 2021 Apr 13;35(2):108974.
Starkl P, Gaudenzio N, Marichal T, Reber LL, Sibilano R, Watzenboeck ML, Fontaine F, Mueller AC, Tsai M, Knapp S, Galli SJ. IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells. Allergy. 2021 Apr 11.
Jeong DE, McCoy M, Artiles K, Ilbay O, Fire A, Nadeau K, Park H, Betts B, Boyd S, Hoh R, Shoura M. Assemblies of putative SARS-CoV2-spike-encoding mRNA sequences for vaccines BNT-162b2 and mRNA-1273. Github. In review.
Dreskin SC, Koppelman SJ, Andorf S, Nadeau KC, Kalra A, Braun W, Negi SS, Chen X, Schein CH. The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds. J Allergy Clin Immunol. 2021 Apr;147(4):1154-1163.
Mann JK, Lutzker L, Holm SM, Margolis HG, Neophytou AM, Eisen EA, Costello S, Tyner T, Holland N, Tindula G, Prunicki M, Nadeau K, Noth EM, Lurmann F, Hammond SK, Balmes JR. Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children. Environ Res. 2021 Apr;195:110870.
Skevaki C, Karsonova A, Karaulov A, Fomina D, Xie M, Chinthrajah S, Nadeau KC, Renz H. SARS-CoV-2 infection and COVID-19 in asthmatics: a complex relationship. Nat Rev Immunol. 2021 Apr;21(4):202-203.
Chinthrajah RS, Galli SJ. Omalizumab in "non-IgE-mediated" diseases. J Allergy Clin Immunol. 2021 Apr;147(4):1207-1208.
Huang Y, Radenkovic D, Perez K, Nadeau K, Verdin E, Furman D. Modeling Predictive Age-Dependent and Age-Independent Symptoms and Comorbidities of Patients Seeking Treatment for COVID-19: Model Development and Validation Study. J Med Internet Res. 2021 Mar 25;23(3):e25696.
Zhou X, Han X, Lyu SC, Bunning B, Kost L, Chang I, Cao S, Sampath V, Nadeau KC. Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy. JCI Insight. 2021 Mar 22;6(6).
Sweeney A, Sampath V, Nadeau KC. Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy. Allergy Asthma Clin Immunol. 2021 Mar 16;17(1):30.
Arasi S, Nurmatov U, Dunn-Galvin A, Daher S, Roberts G, Turner PJ, Shinder SB, Gupta R, Eigenmann P, Nowak-Wegrzyn A, Sánchez Borges MA, Ansotegui IJ, Fernandez-Rivas M, Petrou S, Tanno LK, Vazquez-Ortiz M, Vickery BP, Wong GW, Ebisawa M, Fiocchi A. Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review. World Allergy Organ J. 2021 Mar 11;14(3):
Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, Marconi VC, Ruiz-Palacios GM, Hsieh L, Kline S, Tapson V, Iovine NM, Jain MK, Sweeney DA, El Sahly HM, Branche AR, Regalado Pineda J, Lye DC, Sandkovsky U, Luetkemeyer AF, Cohen SH, Finberg RW, Jackson PEH, Taiwo B, Paules CI, Arguinchona H, Goepfert P, Ahuja N, Frank M, Oh MD, Kim ES, Tan SY, Mularski RA, Nielsen H, Ponce PO, Taylor BS, Larson L, Rouphael NG, Saklawi Y, Cantos VD, Ko ER, Engemann JJ, Amin AN, Watanabe M, Billings J, Elie MC, Davey RT, Burgess TH, Ferreira J, Green M, Makowski M, Cardoso A, de Bono S, Bonnett T, Proschan M, Deye GA, Dempsey W, Nayak SU, Dodd LE, Beigel JH. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. N Engl J Med. 2021 Mar 4;384(9):795-807. (Nadeau KC - listed under Study Team Members)
Pfaar O, Klimek L, Jutel M, Akdis CA, Bousquet J, Breiteneder H, Chinthrajah S, Diamant Z, Eiwegger T, Fokkens WJ, Fritsch HW, Nadeau KC, O'Hehir RE, O'Mahony L, Rief W, Sampath V, Schedlowski M, Torres MJ, Traidl-Hoffmann C, Wang Y, Zhang L, Bonini M, Brehler R, Brough HA, Chivato T, Del Giacco SR, Dramburg S, Gawlik R, Gelincik A, Hoffmann-Sommergruber K, Hox V, Knol EF, Lauerma A, Matricardi PM, Mortz CG, Ollert M, Palomares O, Riggioni C, Schwarze J, Skypala I, Untersmayr E, Walusiak-Skorupa J, Ansotegui IJ, Bachert C, Bedbrook A, Bosnic-Anticevich S, Brussino L, Canonica GW, Cardona V, Carreiro-Martins P, Cruz AA, Czarlewski W, Fonseca JA, Gotua M, Haahtela T, Ivancevich JC, Kuna P, Kvedariene V, Larenas-Linnemann DE, Abdul Latiff AH, Mäkelä M, Morais-Almeida M, Mullol J, Naclerio R, Ohta K, Okamoto Y, Onorato GL, Papadopoulos NG, Patella V, Regateiro FS, Samoliński B, Suppli Ulrik C, Toppila-Salmi S, Valiulis A, Ventura MT, Yorgancioglu A, Zuberbier T, Agache I. COVID-19 pandemic: Practical considerations on the organization of an allergy clinic-An EAACI/ARIA Position Paper. Allergy. 2021 Mar;76(3):648-676.
He Z, Vadali VG, Szabady RL, Zhang W, Norman JM, Roberts B, Tibshirani R, Desai M, Chinthrajah RS, Galli SJ, Andorf S, Nadeau KC. Increased diversity of gut microbiota during active oral immunotherapy in peanut-allergic adults. Allergy. 2021 Mar;76(3):927-930.
Bousquet J, Jutel M, Akdis CA, Klimek L, Pfaar O, Nadeau KC, Eiwegger T, Bedbrook A, Ansotegui IJ, Anto JM, Bachert C, Bateman ED, Bennoor KS, Berghea EC, Bergmann KC, Blain H, Bonini M, Bosnic-Anticevich S, Boulet LP, Brussino L, Buhl R, Camargos P, Canonica GW, Cardona V, Casale T, Chinthrajah S, Akdis M, Chivato T, Christoff G, Cruz AA, Czarlewski W, Del Giacco S, Du H, El-Gamal Y, Fokkens WJ, Fonseca JA, Gao Y, Gaga M, Gemicioglu B, Gotua M, Haahtela T, Halpin D, Hamelmann E, Hoffmann-Sommergruber K, Humbert M, Ilina N, Ivancevich JC, Joos G, Khaitov M, Kirenga B, Knol EF, Ko FW, Koskinen S, Kowalski ML, Kraxner H, Kudlay D, Kuna P, Kupczyk M, Kvedariene V, Abdul Latiff AH, Le LT, Levin M, Larenas-Linnemann D, Louis R, Masjedi MR, Melén E, Mihaltan F, Milenkovic B, Mohammad Y, Morais-Almeida M, Mullol J, Namazova L, Neffen H, Nunes E, O'Byrne P, O'Hehir R, O'Mahony L, Ohta K, Okamoto Y, Onorato GL, Panzner P, Papadopoulos NG, Passalacqua G, Patella V, Pawankar R, Pham-Thi N, Pigearias B, Popov TA, Puggioni F, Regateiro FS, Rolla G, Rottem M, Samolinski B, Sastre J, Schwarze J, Sheikh A, Scichilone N, Soto-Quiros M, Soto-Martinez M, Sova M, Nicola S, Stelmach R, Suppli-Ulrik C, Taborda-Barata L, To T, Tomazic PV, Toppila-Salmi S, Tsiligianni I, Usmani O, Valiulis A, Ventura MT, Viegi G, Vontetsianos T, Wang Y, Williams S, Wong GWK, Yorgancioglu A, Zernotti M, Zidarn M, Zuberbier T, Agache I. ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020). Allergy. 2021 Mar;76(3):689-697.
Goshua A, Gomez J, Erny B, Burke M, Luby S, Sokolow S, LaBeaud AD, Auerbach P, Gisondi MA, Nadeau K. Addressing Climate Change and Its Effects on Human Health: A Call to Action for Medical Schools. Acad Med. 2021 Mar 1;96(3):324-328.
Balz K, Kaushik A, Chen M, Cemic F, Heger V, Renz H, Nadeau K, Skevaki C. Homologies between SARS-CoV-2 and allergen proteins may direct T cell-mediated heterologous immune responses. Sci Rep. 2021 Feb 26;11(1):4792.
Prunicki M, Cauwenberghs N, Lee J, Zhou X, Movassagh H, Noth E, Lurmann F, Hammond SK, Balmes JR, Desai M, Wu JC, Nadeau KC. Air pollution exposure is linked with methylation of immunoregulatory genes, altered immune cell profiles, and increased blood pressure in children. Sci Rep. 2021 Feb 18;11(1):4067.
Wanet A, Bassal MA, Patel SB, Marchi F, Mariani SA, Ahmed N, Zhang H, Borchiellini M, Chen S, Zhang J, Di Ruscio A, Miyake K, Tsai M, Paranjape A, Park SY, Karasuyama H, Schroeder T, Dzierzak E, Galli SJ, Tenen DG, Welner RS. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021 Feb 5;6(56):eaba0178.
Muehe A, Nejadnik,Hossein,Muehe H, Rosenberg J, Gharibi H, Saei AA, Lyu S, Nadeau KC, Mahmoudi M, Daldrup-Link HE. Can the biomolecular corona induce an allergic reaction?—A proof-of-concept study. Biointerphases. 2021 February; 16(1).
Sharif H, Acharya S, Dhondalay GKR, Varricchi G, Krasner-Macleod S, Laisuan W, Switzer A, Lenormand M, Kashe E, Parkin RV, Yi Y, Koc M, Fedina O, Vilà-Nadal G, Marone G, Eifan A, Scadding GW, Fear DJ, Nadeau KC, Durham SR, Shamji MH. Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy. J Allergy Clin Immunol. 2021 Feb;147(2):663-676.
Lopez-Lopez C, Jaramillo-Polanco J, Talavera K, Alpizar YA, Feyerabend TB, Rodewald HR, Farre R, Redegeld FA, Si J, Raes J, Breynaert C, Schrijvers R, Bosteels C, Lambrecht BN, Boyd SD, Hoh RA, Cabooter D, Nelis M, Augustijns P, Hendrix S, Strid J, Bisschops R, Reed DE, Vanner SJ, Denadai-Souza A, Wouters MM, Boeckxstaens GE. Local immune response to food antigens drives meal-induced abdominal pain. Nature. 2021 Feb;590(7844):151-156.
Aguilera-Lizarraga J, Florens MV, Viola MF, Jain P, Decraecker L, Appeltans I, Cuende-Estevez M, Fabre N, Van Beek K, Perna E, Balemans D, Stakenborg N, Theofanous S, Bosmans G, Mondelaers SU, Matteoli G, Ibiza Martínez S, Lopez-Lopez C, Jaramillo-Polanco J, Talavera K, Alpizar YA, Feyerabend TB, Rodewald HR, Farre R, Redegeld FA, Si J, Raes J, Breynaert C, Schrijvers R, Bosteels C, Lambrecht BN, Boyd SD, Hoh RA, Cabooter D, Nelis M, Augustijns P, Hendrix S, Strid J, Bisschops R, Reed DE, Vanner SJ, Denadai-Souza A, Wouters MM, Boeckxstaens GE. Local immune response to food antigens drives meal-induced abdominal pain. Nature. 2021 Feb;590(7844):151-156.
Bao R, Hesser LA, He Z, Zhou X, Nadeau KC*, Nagler CR*. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021 Jan 19;131(2). (co-senior authors)
Yan Z, Maecker HT, Brodin P, Nygaard UC, Lyu SC, Davis MM, Nadeau KC, Andorf S. Aging and CMV discordance are associated with increased immune diversity between monozygotic twins. Immun Ageing. 2021 Jan 18;18(1):5.
Gupta RS, Fierstein JL, Boon KL, Kanaley MK, Bozen A, Kan K, Vojta D, Warren CM. Sensor-Based Electronic Monitoring for Asthma: A Randomized Controlled Trial. Pediatrics. 2021 Jan;147(1):e20201330.
Turner-Bowker DM, Jalbert JJ, Krohe M, Yaworsky A, Kelly MT, Padilla B, Chaston E, Radin A, Mastey V, Nadeau KC. A novel patient-reported outcomes instrument assessing the side effects of peanut oral immunotherapy. Ann Allergy Asthma Immunol. 2021 Jan;126(1):61-68.
Warren CM, Turner PJ, Chinthrajah RS, Gupta RS. Advancing Food Allergy Through Epidemiology: Understanding and Addressing Disparities in Food Allergy Management and Outcomes. J Allergy Clin Immunol Pract. 2021 Jan;9(1):110-118.
Yu W, Zhou X, Lyu SC, Davis MM, Nadeau KC. Regulation of peanut-specific CD8+ T cells from nonallergic individuals. J Allergy Clin Immunol.2021 Jan;147(1):385-387.e1.
Chakraborty S, Gonzalez J, Edwards K, Mallajosyula V, Buzzanco AS, Sherwood R, Buffone C, Kathale N, Providenza S, Xie MM, Andrews JR, Blish CA, Singh U, Dugan H, Wilson PC, Pham TD, Boyd SD, Nadeau KC, Pinsky BA, Zhang S, Memoli MJ, Taubenberger JK, Morales T, Schapiro JM, Tan GS, Jagannathan P, Wang TT. Proinflammatory IgG Fc structures in patients with severe COVID-19. Nat Immunol. 2021 Jan;22(1):67-73

2019 Publications

Breiteneder H, Diamant Z, Eiwegger T, Fokkens WJ, Traidl-Hoffmann C, Nadeau K, O’Hehir R, O‘Mahony L, Pfaar O, Torres MJ, Wang DY, Zhang L, Akdis CA. Future trends in mechanisms and patient care in allergic diseases. Allergy. 2019 Dec;74(12):2293-2311.
Long A, Bunning B, Borro M, Sampath V, Nadeau, KC. The Future of omics for clinical practice. Ann Allergy Asthma Immunol. 2019 Dec;123(6):535-536.
Chinthrajah S, Cao S, Liu C, Lyu SC, Sindher SB, Long A, Sampath V, Petroni D, Londei M, Nadeau KC. . Phase 2a randomized, placebo-controlled study of anti-IL-33 inpeanut allergy. JCI Insight. 2019 Nov 14;4(22).
Kivistö JE, Clarke A, Dery A, De Schryver S, Shand G, Huhtala H, Mäkelä MJ, Asai Y, Nadeau K, Harada L, Chan ES, Ben-Shoshan M. Genetic and environmental susceptibility to food allergy in a registry of twins. J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2916-2918.
Iliopoulou BP, Hsu K, Pérez-Cruz M, Tang SW, Pang WW, Erkers T, Kambham N, Freeman GJ, Dekruyff RH, Meyer EH. Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation. Blood Adv. 2019 Nov 12;3(21):3419-3431.
Eiwegger T, Anagnostou K, Arasi S, Bégin P, Ben-Shoshan M, Beyer K, Blumchen K, Brough H, Caubet JC, Chan ES, Chinthrajah S, Davis CM, Roches AD, Du Toit G, Elizur A, Galli SJ, Håland G, Hoffmann-Sommergruber K, Kim H, Leung DYM, Muraro A, Nurmatov UB, Pajno GB, Sindher S, Szepfalusi Z, Torres MJ, Upton J, Worm M, Nadeau K. ICER report for peanut OIT comes up short. Ann Allergy Asthma Immunol. 2019 Nov;123(5):430-432.
Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation. Nat Immunol. 2019 Nov;20(11):1435-1443.
Du Toit G, Elizur A, Nadeau KC. Cow's Milk and Vitamin D Supplementation in Infants-Timing Is Everything. JAMA Pediatr. 2019 Oct 21. [Epub ahead of Print].
Chinthrajah RS, Purington N, Andorf S, Long A, O'Laughlin KL, Lyu SC, Manohar M, Boyd SD, Tibshirani R, Maecker H, Plaut M, Mukai K, Tsai M, Desai M, Galli SJ, Nadeau KC. Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2019 Oct 19;394(10207):1437-1449.
Yadava K, Medina CO, Ishak H, Gurevich I, Kuipers H, Shamskhou EA, Koliesnik IO, Moon JJ, Weaver C, Nadeau KC, Bollyky PL. Natural Tr1-like cells do not confer long-term tolerogenic memory. Elife. 2019 Oct 11;8.
Prunicki M, Kelsey R, Lee J, Zhou X, Smith E, Haddad F, Wu J, Nadeau K. The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children. Allergy. Oct;74(10):1989-1991.
Che H, Zhang Y, Jiang S, Jin T, Lyu SC, Nadeau KC, McHugh T. Almond (Prunus dulcis) Allergen Pru du 8, the First Member of a New Family of Food Allergens. J Agric Food Chem. 2019 Aug 7;67(31):8626-8631.
Davis MM, Boyd SD. Recent progress in the analysis of αβT cell and B cellreceptor repertoires. Curr Opin Immunol. 2019 Aug;59:109-114.
Yu S, Leung KM, Kim HY, Umetsu SE, Xiao Y, Albacker LA, Lee HJ, Umetsu DT,Freeman GJ, DeKruyff RH. Blockade of Repulsive guidance molecule b (RGMb)inhibits allergen-induced airways disease. J Allergy Clin Immunol. 2019 Jul;144(1):94-108.e11.
Ebert A, Joshi AU, Andorf S, Dai Y, Sampathkumar S, Chen H, Li Y, Garg P, Toischer K, Hasenfuss G, Mochly-Rosen D, Wu JC. Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes. Circ Res. 2019 Jun 21;125(1):90-103.
Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling Cardiovascular Risks of E-Cigarettes with Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 Jun 4;73(21):2722-2737.
Upton J, Montserrat A, Nadeau K. A perspective on the pediatric death from oral food challenge reported from the Allergy Vigilance Network. Allergy. 2019 Jun;74(6):1035-1036.
Howe LC, Leibowitz KA, Perry MA, Block W, Kaptchuk TJ , Nadeau KC, Alia J. Crum AJ. Changing Patient Mindsets About Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial. J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1550-1559.
Wheatley LM, Wood R, Nadeau K, Liu A, Zoratti E, Bacharier L, Brittain E, Calderon M, Casale T, Chipps B, Cox L, Creticos PS, Desai M, Dreborg S, Durham S, Gergen PJ, Gruchalla R, Nelson H, O'Hehir RE, Plaut M, Schwaninger JM, Tilles S, Vickery B, Wittenberg KM, Togias A. Mind the gaps: clinical trial concepts to address unanswered questions in aeroallergen immunotherapy. An NIAID/AHRQ Workshop. J Allergy Clin Immunol. 2019 May;143(5):1711-1726.
Yu W, Zhou X, Dunham D, Lyu S, Manohar M, Zhang W, Zhao F, Davis MM, Nadeau K. Allergen Specific CD8+ T cells in Peanut Allergic Individuals. J Allergy Clin Immunol. 2019 May;143(5):1948-1952.
Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA. Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells. J Allergy Clin Immunol. 2019 May;143(5):1892-1903.
Emeny RT, Korrick SA, Li Z, Nadeau K, Madan J, Jackson B, Baker E, Karagas MR. Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study. Environ Res. 2019 Apr;171:523-529.
Sampath V, Nadeau KC. Newly identified T cell subsets in mechanistic studies of food immunotherapy. J Clin Invest. 2019 Apr 1;129(4):1431-1440.
Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 Mar 12;321(10):946-955.
Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M. Report from the National Institute of Allergy and Infectious Diseases Workshop on "Atopic Dermatitis and the Atopic March: Mechanisms and Interventions". J Allergy Clin Immunol. 2019 Mar;143(3):894-913.
Suarez-Farinas M, Suprun M, Chang HL, Gimenez G, Grishina G, Getts R, Nadeau K, Wood RA, Sampson HA. Predicting development of "sustained unresponsiveness" to milk oral immunotherapy using epitope profiles. J Allergy Clin Immunol. 2019 Mar;143(3):1038-1046.
Galli SJ. Complexities in analyzing human basophil responses to autoantibodies to IgE or FcεRI. J Allergy Clin Immunol. 2019 Mar;143(3):932-934.
Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider L, Oettgen HC. IgE blockade during food allergen ingestion enhances the induction of inhibitory IgG antibodies. Ann Allergy Asthma Immunol. 2019 Feb;122(2):213-215.
Nowak-Węgrzyn A, Wood RA, Nadeau KC, Pongracic JA, Henning AK, Lindblad RW, Beyer K, Sampson HA. Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy. J Allergy Clin Immunol. 2019 Feb;143(2):651-661.e9.
Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol. 2019 Feb;20(2):129-140.
Andorf S, Purington N, Kumar D, Long A, O'Laughlin K, Sicherer S, Sampson H, Cianferoni A, Whitehorn TB, Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Desai M, Galli SJ, Rael E, Assa’ad A, Chinthrajah S, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Nadeau K. A Phase 2 randomized controlled multisite study using omalizumab-facilitated rapid desensitization to test continued vs discontinued dosing in multifood allergic individuals. Lancet eClinicalMedicine. 2019. Jan 21. 2019 Jan; 7:27-48.
Che H, Zhang Y, Lyu SC, Nadeau KC, McHugh T. Identification of almond (Prunus dulcis) vicilin as a food allergen. J Agric Food Chem. 2019 Jan 9;67(1):425-432.
Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, Schleimer RP, Nadeau KC. Prevalence and Severity of Food Allergies Among US Adults. JAMA Netw Open. 2019 Jan 4;2(1):e185630.

2018 Publications

Croote D, Darmanis S, Nadeau KC, Quake SR. High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes. Science. 2018 Dec 14;362(6420):1306-1309.
Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang J, Davis MM, Nadeau KC. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018 Dec;142(6).
Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Andorf S, Tupa D, Kumar D, Woch MA, O'Laughlin KL, Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Nadeau KC, Chinthrajah RS. Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens. Front Immunol. 2018 Nov 27;9:2689.
PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018 Nov 22;379(21):1991-2001.
Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim KP, Bunning B, Doyle AD, Jacobsen EA, Boyd SD, Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Chinthrajah RS. Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy. Front Immunol. 2018 Nov 22;9:2624.
Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT. Differences in multiple immune parameters between Indian and U.S. infants. PLoS One. 2018 Nov 16;13(11):e0207297.
Yu M, Mukai K, Tsai M, Galli SJ. Thirdhand smoke component can exacerbate a mouse asthma model via mast cells. J Allergy Clin Immunol. 2018 Nov;142(5):1618-1627.e9.
Birrueta G, Tripple V, Pham J, Manohar M, James EA, Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V. Peanut-specific T cell responses in patients with different clinical reactivity. PLoS One. 2018 Oct 10;13(10):e0204620.
Sindher SB, Long A, Acharya S, Sampath V, Nadeau KC. The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses. Clin Rev Allergy Immunol. 2018 Oct;55(2):190-204.
Purington N, Chinthrajah RS, Long A, Sindher S, Andorf S, O'Laughlin K, Woch MA, Scheiber AJ, Assa’ad A, Pongracic J, Spergel J, Tam J, Tilles S, Wang J, Galli SJ, Desai M, Nadeau KC. Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges. Frontiers in Immunology. 2018 Sep 21;9:2057.
Zhang W, Sindher S, Sampath V, Nadeau KC. Comparison of Sublingual Immunotherapy and Oral Immunotherapy in Peanut Allergy. Allergo J Int. 2018 September; 27(6):153-161.
Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee C, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 Jul 31;24(5):1377-1388.
Rice MB, Malea NM, Pinkerton KE, Schwartz J, Nadeau KC, Browner CM, Whitehouse S, Thurston GD. Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health: Where Science Meets Policy. Ann Am Thorac Soc. 2018 Jul;15(7):791-798.
Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC. Development of a Tool Predicting Severity of Allergic Reaction During Peanut Challenge. Ann Allergy Asthma Immunol. 2018 Jul;121(1):69-76.e2.
Chinthrajah RS, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC. High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma. Ann Allergy Asthma Immunol. 2018 Jul;121(1):117-119.e1.
Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW. Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects. Front Immunol. 2018 Jun 25;9:1408.
Klein O, Roded A, Hirschberg K, Fukuda M, Galli SJ, Sagi-Eisenberg R. Imaging FITC-dextran as a Reporter for Regulated Exocytosis. J Vis Exp. 2018 Jun 20;(136).
Gaudenzio N, Marichal T, Galli SJ, Reber LL. Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity. Front Immunol. 2018 Jun 5;9:1275.
Zhang W, Lin C, Sampath V, Nadeau K. Impact of allergen immunotherapy in allergic asthma. Immunotherapy. 2018 Jun;10(7):579-593.
Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ. Isotype-Specific Agglutination- PCR (ISAP): a sensitive and multiplex method for measuring allergen-specific IgE. J Allergy Clin Immunol. 2018 May;141(5):1901-1904.e15.
Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O'Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A; EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018 Apr;73(4):799-815.
Sampath V, Sindher SB, Zhang W, Nadeau KC. New Treatment Directions in Food Allergy. Ann Allergy Asthma Immunol. 2018 Mar;120(3):254-262.
Mukai K, Tsai M, Saito H, Galli SJ. Mast cells as sources of cytokines, chemokines, and growth factors. Immunol Rev. 2018 Mar;282(1):121-150.
Andorf S, Purington N, Block WM, Long AJ, Tupa D, Brittain E, Spergel AR, Desai M, Galli SJ, Nadeau KC, Chinthrajah RS. Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):85-94.
Prunicki M, Stell L, Dinakarpandian D, De Planell-Saguerd M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC. Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma. Clin Epigenetics. 2018 Jan 5;10:2.
Dhondalay GK, Rael E, Acharya, S, Zhang W, Sampath V, Galli SJ, Tibshirani, R, Boyd SD, Maecker, H, Nadeau KC, Andorf S. Food allergy and omics. J Allergy Clin Immunol. 2018 Jan;141:20-29.
Pellerin L, Jenks JA, Chinthrajah S, Dominguez T, Block W, Zhou X, Noshirvan A, Gregori S, Roncarolo MG, Nadeau KC, Bacchetta R. Peanut-specific Tr1 cells induced in vitro from allergic individuals are functionally impaired. J Allergy Clin Immunol. 2018 Jan;141(1):202-213.e8.
Galli SJ, Gaudenzio N. Human mast cells as antigen-presenting cells: when is this role important in vivo? J Allergy Clin Immunol. 2018 Jan;141(1):92-93.
Tam IYS, Ng CW, Lau HYA, Tam SY. Degradation of Monocyte Chemoattractant Protein-1 by Tryptase Co-Released in Immunoglobulin E-Dependent Activation of Primary Human Cultured Mast Cells. Int Arch Allergy Immunol. 2018;177(3):199-206.

2017 Publications

Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V,Chinthrajah RS, Nadeau KC. Feasibility of sustained response through long-term dosing in food allergy immunotherapy. Allergy Asthma Clin Immunol. 2017 Dec 21;13:52.
Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V, Chinthrajah RS, Nadeau KC. Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab. Allergy Asthma Clin Immunol. 2017 Dec 21;13:51.
Klein O, Roded A, Zur N, Azouz NP, Pasternak O, Hirschberg K, Hammel I, Roche PA, Yatsu A, Fukuda M, Galli SJ, Sagi-Eisenberg R. Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis. Sci Rep. 2017 Nov 10;7(1):15315.
Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial. JAMA. 2017 Nov 14;318(18):1798-1809.
Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC. Combining anti-IgE with oral immunotherapy. Pediatr Allergy Immunol. 2017 Nov;28(7):619-627.
Elizur A, Bollyky JB, Block WM. Elimination diet and the development of multiple tree-nut allergies. Pediatr Res. 2017 Oct;82(4):671-677
Frischmeyer-Guerrerio PA, Masilamani M, Gu W, Brittain E, Wood R, Kim J, Nadeau K, Jarvinen KM, Grishin A, Lindblad R, Sampson HA. Mechanistic Correlates of Clinical Responses to Omalizumab in the Setting of Oral Immunotherapy for Milk Allergy. J Allergy Clin Immunol. 2017 Oct;140(4):1043-1053.e8.
Andorf S, Borres MP, Block W, Tupa D, Bollyky JB, Sampath V, Elizur A, Lidholm, J, Jones JE, Galli SJ, Chinthrajah RS, Nadeau KC. Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children. J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1325-1334.e4.
Boyd SD, Hoh RA, Nadeau KC, Galli SJ. Immune monitoring for precision medicine in allergy and asthma. Curr Opin Immunol. 2017 Sep 6;48:82-91.
Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2017 Aug;140(2):335-348.
Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis. Allergy. 2017 Aug;72(8):1133-1147.
Chang HY, Nadeau KC. IL-4Rα Inhibitor for Atopic Disease. Cell. 2017 Jul 13;170(2):222.
Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev-Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC. Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. Allergy. 2017 Jul;72(7):1006-1021.
Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One. 2017 Jun 29;12(6):e0179606.
Park HK, Cheng KC, Tetteh AO, Hildemann LM, Nadeau KC. Effectiveness of Air Purifier on Health Outcomes and Indoor Particles in Homes of Children with Allergic Diseases in Fresno: A Pilot Study. J Asthma. 2017 May;54(4):341-346.
Galli SJ. Mast Cells and KIT as Potential Therapeutic Targets in Severe Asthma. N Engl J Med. 2017 May 18;376(20):1983-1984.
Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR. Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study. J Occup Environ Med. 2017 May;59(5):446-452.
Otani IM, Nadeau KC. Biologic Therapies for Immunoglobulin E-mediated Food allergy and Eosinophilic Esophagitis. Immunol Allergy Clin North Am. 2017 May;37(2):369-396.
Mukai K, Karasuyama H, Kabashima K, Kubo M, Galli SJ. Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4(+) T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect Immun. 2017 Apr 21;85(5).
Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 Apr;125(4):511-526.
Freeland DMH, Manohar M, Andorf S, Hobson BD, Zhang W, Nadeau KC. Oral immunotherapy for food allergy. Semin Immunol. 2017 Apr;30:36-44.
MacGinnitie AJ, Rachid R, Gragg H, Little SV, Lakin P, Cianferoni A, Heimall J, Makhija M, Robison R, Chinthrajah RS, Lee J, Lebovidge J, Dominguez T, Rooney C, Lewis MO, Koss J, Burke-Roberts E, Chin K, Logvinenko T, Pongracic JA, Umetsu DT, Spergel J, Nadeau KC, Schneider LC. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017 Mar;139(3):873-881.e8.
Ahuja SK, Manoharan MS, Harper NL, Jimenez F, Hobson BD, Martinez H, Ingale P, Liu YG, Carrillo A, Lou Z, Kellog DL, Ahuja SS, Rather CG, Esch RE, Ramirez DA, Clark RA, Nadeau K, Andrews CP, Jacobs RL, He W. Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. J Allergy Clin Immunol. 2017 Mar;139(3):844-854.
Mukai K, Gaudenzio N, Gupta S, Vivanco N, Bendall SC, Maecker HT, Chinthrajah RS, Tsai M, Nadeau KC, Galli SJ. Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Mukai K, Chinthrajah RS, Nadeau KC, Tsai M, Gaudenzio N, Galli SJ. A new fluorescent-avidin-based method for quantifying basophil activation in whole blood. J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11.
Balbino B, Sibilano R, Starkl P, Marichal T, Gaudenzio N, Karasuyama H, Bruhns P, Tsai M, Reber LL, Galli SJ. Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J Allergy Clin Immunol. 2017 Feb;139(2):584-596.e10.
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T. Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4. J Agric Food Chem. 2017 Jan 18;65(2):454-462.
Beutier H, Gillis CM, Iannascoli B, Godon O, England P, Sibilano R, Reber LL, Galli SJ, Cragg MS, Van Rooijen N, Mancardi DA, Bruhns P, Jönsson F. IgG subclasses determine pathways of anaphylaxis in mice. J Allergy Clin Immunol. 2017 Jan;139(1):269-280.e7.
Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2017 Jan;56(1):109-120.
Sampath V, Tupa D, Graham MT, Chatila TA, Spergel JM, Nadeau KC. Deciphering the black box of food allergy mechanisms. Ann Allergy Asthma Immunol. 2017 Jan;118(1):21-27.

2016 Publications

Sibilano R, Gaudenzio N, DeGorter MK, Reber LL, Hernandez JD, Starkl PM, Zurek OW, Tsai M, Zahner S, Montgomery SB, Roers A, Kronenberg M, Yu M, Galli SJ. A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice. Nat Commun. 2016 Dec 16;7:13696.
Yu W, Freeland DM, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016 Dec;16(12):751-765.
Zhang Y, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, McHugh TH. Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2. Food Research International. 2016 Dec;90:268-274.
Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2016 Nov 1;126(11).
Bunning BJ, DeKruyff RH, Nadeau KC. Epigenetic Changes During Food-Specific Immunotherapy. Curr Allergy Asthma Rep. 2016 Nov;16(12):87.
Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA. The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. Nat Commun. 2016 Oct 27;7:13198
Hussey Freeland DM, Fan-Minogue H, Spergel JM, Chatila TA, Nadeau KC. Advances in food allergy oral immunotherapy: toward tolerance. Curr Opin Immunol. 2016 Oct;42:119-123
Graham MT, Andorf S, Spergel JM, Chatila TA, Nadeau KC. Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. Curr Allergy Asthma Rep. 2016 Oct;16(10):75.
Mukai K, Tsai M, Starkl P, Marichal T, Galli SJ. IgE and mast cells in host defense against parasites and venoms. Semin Immunopathol. 2016 Sep;38(5):581-603.
Rael E. Allergen Immunotherapy . Prim Care. 2016 Sep;43(3):487-94.
Dhami S, Nurmatov U, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen L, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A. Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review. Clin Transl Allergy. 2016 Jul 5;6:24.
Ng E, Nadeau KC, Wang SX. Giant magnetoresistive sensor array for sensitive and specific multiplexed food allergen detection. Biosens Bioelectron. 2016 Jun 15;15;80:359-65.
Farzan SF, Li Z, Korrick SA, Spiegelman D, Enelow R, Nadeau K, Baker E, Karagas MR. Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort. Environ Health Perspect. 2016 Jun;124(6):840-7.
Zhang Y, Lee B, Du WX, Lyu SC, Nadeau KC, Grauke LJ, Zhang Y, Wang S, Fan Y, Yi J, McHugh TH. Identification and Characterization of a New Pecan [Carya illinoinensis (Wangenh.) K. Koch] Allergen, Car i 2. J Agric Food Chem. 2016 May 25;64(20):4146-51
Pennington LF, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham MT, Nadeau KC, Eggel A, Jardetzky TS. Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nat Commun. 2016 May 19;7:11610.
Galli SJ. Toward precision medicine and health: Opportunities and challenges in allergic diseases. J Allergy Clin Immunol. 2016 May;137(5):1289-300.
Wood RA, Kim JS, Lindblad R, Nadeau K, Henning AK, Dawson P, Plaut M, Sampson HA. A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy. J Allergy Clin Immunol. 2016 Apr;137(4):1103-10.e1-11.
Chinthrajah RS, Hernandez JD, Boyd SD, Galli SJ, Nadeau KC. Molecular and cellular mechanisms of food allergy and food tolerance. J Allergy Clin Immunol. 2016 Apr;137(4):984-97.
Ryan JF, Hovde R, Glanville J, Lyu S-C, Ji X, Gupta S, Tibshirani RJ, Jay DC, Boyd SD, Chinthrajah RS, Davis MM, Galli SJ, Maecker HT, Nadeau KC. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1286-95.
Bauer RN, Chinthrajah RS, Andorf S, Hobson B, Miller RL, Nadeau KC. T-Cell Immunophenotyping of Second-Hand Smoke-related Asthma. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S95.
Chang, A, Block W, Bollyky JB, Chinthrajah RS, Nadeau KC, Elizur A. Exploring Correlations Between Cross-Reactive Tree Nuts in Multiple Food Allergic Patients. J Allergy Clin Immunol. 2016 Feb;137(2):AB200.
Singh S, Kshirsagar RA , Dominguez TLR, Tupa D, Block W, Chinthrajah RS, Nadeau KC. Long-Term Follow-up of Oral Immunotherapy for Multiple Food Allergies. J Allergy Clin Immunol, 2016 Feb;137(2):AB132.
Elizur A, Bollyky JB, Block W, Nadeau KC. Different Triggers for the Diagnosis of Individual Food Allergies in Multiple Food Allergic Patients. J Allergy Clin Immunol, 2016 Feb;137(2):AB156.
Prunicki M, Zhou X, de Planell-Saguer M, Miller R, Nadeau KC. Identification of Tr1 Cells and Other CD4+ T Cell Subsets in Humans Using Mass Cytometry: A Tool for Understanding Asthma. J Allergy Clin Immuol, 2016 Feb;137(2):AB410.
Slatkin SC, Tupa D, Nadeau KC, Chinthrajah RS. Fraction of Exhaled Nitric Oxide (FeNO) and Abdominal Pain and/or Vomiting in Reaction to Oral Food Challenge. J Allergy Clin Immunol, 2016 Feb;137(2):AB135.
De Schryver S, Dery A, Clarke AE, Nadeau KC, Harada L, Greenwood C, Weatherall K, Daley D, Asai Y, Bamforth F, Ben-Shoshan M. START: Susceptibility to Food Allergies in a Registry of Twins. J Allergy Clin Immunol, 2016 Feb;137(2):AB152
Zhang Y, Du WX, Fan Y, Nadeau KC, McHugh TH. Prediction and Identification of Korean Pine (Pinus koraiensis) Vicilin As a Food. J Allergy Clin Immunol, 2016 Feb;137(2):AB267.
Noshirvan A, Petroni DH, Tsai M, Galli SJ, Chintrajah RS, Nadeau KC. Trends in Adverse Reactions Requiring Epinephrine in the Build-up Phase of Oral Immunotherapy. J Allergy Clin Immunol, 2016 Feb;137(2):AB131.
Galli SJ. The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis. Am J Pathol. 2016 Feb;186(2):212-24.
Ma J, Strub P, Lv N, Xiao L, Camargo CA Jr, Buist AS, Lavori PW, Wilson SR, Nadeau KC, Rosas LG. Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma. Eur Respir J. 2016 Jan;47(1):122-32.
Hoh RA, Joshi SA, Liu Y, Wang C, Roskin KM, Lee JY, Pham T, Looney TJ, Jackson KJ, Dixit VP, King J, Lyu SC, Jenks J, Hamilton RG, Nadeau KC, Boyd SD. Single B-cell deconvolution of peanut-specific antibody responses in allergic patients. J Allergy Clin Immunol. 2016 Jan;137(1):157-67.
Galli SJ, Starkl P, Marichal T, Tsai M. Mast cells and IgE in defense against venoms: Possible "good side" of allergy?Allergol Int. 2016 Jan;65(1):3-15.
Cheng K-C, Zheng D, Tetteh AO, Park H-K, Nadeau KC & Hildemann LM. Personal exposure to airborne particulate matter due to residential dryer lint cleaning. Building and Environment. 2016. 98:145-149.
Cheng K-C, Park H-K, Tetteh AO, Zheng D, Ouellette NT, Nadeau KC & Hildemann LM. Mixing and sink effects of air purifiers on indoor PM2.5 concentrations: A pilot study of eight residential homes in Fresno, California. Aerosol Science and Technology. 2016. 50(8):835-845.

2015 Publications

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma: An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72.
Chinthrajah RS, Tupa D, Prince BT, Block WM, Rosa JS, Singh AM, Nadeau K. Diagnosis of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1393-408.
Prince BT, Mandel MJ, Nadeau K, Singh AM. Gut Microbiome and the Development of Food Allergy and Allergic Disease. Pediatr Clin North Am. 2015 Dec;62(6):1479-92.
Geifman N, Bollyky J, Bhattacharya S, Butte AJ. Opening clinical trial data:are the voluntary data-sharing portals enough? BMC Med. 2015 Nov 11;13:280.
Walter JE, Rosen LB, Csomos K, et al. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 2;125(11):4135-48.
Bégin P, Schulze J, Baron U, Olek S, Bauer RN, Passerini L, Baccheta R, Nadeau KC. Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region. Clin Transl Allergy. 2015 Oct 20;5:35.
Vercelli D, Galli SJ. Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment. Curr Opin Immunol. 2015 Oct;36:ix-xi.
Roskin KM, Simchoni N, Liu Y, Lee JY, Seo K, Hoh RA, Pham T, Park JH, Furman D, Dekker CL, Davis MM, James JA, Nadeau KC, Cunningham-Rundles C, Boyd SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Sci Transl Med. 2015 Aug 26;7(302):302ra135
Lambrecht BN, Galli SJ. SnapShot: Integrated Type 2 Immune Responses. Immunity. 2015 Aug 18; 43(2):408-408.
Quake C, Nadeau KC. The role of epigenetic mediation and the future of food allergy research. Semin Cell Dev Biol. 2015 Jul;43:125-30.
Sabounchi S, Bollyky J, Nadeau K. Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases. Curr Allergy Asthma Rep. 2015 Jun;15(6):533.
Bégin P, Nadeau KC. Changes in peanut-specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol. 2015 Jun;135(6):1636-8.
Reber LL, Sibilano R, Mukai K, Galli SJ. Potential effector and immunoregulatory functions of mast cells in mucosal immunity. Mucosal Immunol. 2015 May; 8(3):444-63.
Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A. PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity. J Allergy Clin Immunol. 2015 Apr 1; S0091-6749(15)00185-2.
Hong X, Hao K, Ladd-Acosta C, Hansen KD, Tsai HJ, Liu X, Xu X, Thornton TA, Caruso D, Keet CA, Sun Y, Wang G, Luo W, Kumar R, Fuleihan R, Singh AM, Kim JS, Story RE, Gupta RS, Gao P, Chen Z, Walker SO, Bartell TR, Beaty TH, Fallin MD, Schleimer R, Holt PG, Nadeau KC, Wood RA, Pongracic JA, Weeks DE, Wang X. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
Bauer RN, Manohar M, Singh AM, Jay DC, Nadeau KC. The future of biologics: Applications for food allergy. J Allergy Clin Immunol. 2015 Feb;135(2):312-323.
Pajno GB, Nadeau KC, Passalacqua G, Caminiti L, Hobson B, Jay DC, Arasi S, Chiera F, Salzano G. The evolution of allergen and non-specific immunotherapy: past achievements, current applications and future outlook. Expert Rev Clin Immunol. 2015 Jan;11(1):141-54.
Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth B, Mann J, Pratt B, Balmes J, Hammond K, Eisen E, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clin Exp Allergy. 2015 Jan;45(1):238-48.

2014 Publications

Graham MT, Nadeau KC. Lessons learned from mice and man: mimicking human allergy through mouse models. Clin Immunol. 2014 Nov;155(1):1-16.
Sleiman P, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau KC, Bredenoord A, Furuta G, Spergel J, and Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nature Communications. 2014 Nov 19;5:5593. *Participated in enrolling patients, provided technical support and material support.
Arasi S, Klingbeil E, Dominguez T, and Nadeau KC. Two year long term data on Quality of Life in Multiple Food Allergy Oral Immunotherapy. Allergy, Asthma, and Clinical Immunology. 2014 Nov; 10:57
Jay D, Manohar M, and Nadeau KC. Immune Mechanisms of Sublingual Immunotherapy. Current Allergy and Asthma Reports. 2014 Nov;14(11):473.
Lv N, Xiao L, Camargo C, Wilson S, Buist S, Strub P, Nadeau K, and Ma J. Abdominal and General Adiposity and Level of Asthma Control in Adults with Uncontrolled Asthma. Annals of the American Thoracic Society. 2014 Oct;11(8):1218-24. *Participated in acquisition of data, technical support, material support, and analysis and interpretation of data.
Luskin AT, Chipps BE, Rasouliyan L, Miller DP, Haselkorn T, Dorenbaum A. Impact of asthma exacerbations and asthma triggers on asthma-related quality of life in patients with severe or difficult-to-treat asthma. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):544-52. [Epub 2014 Jul 3]
Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, Nadeau KC, Kaiser S, Peters T, Perez A, Jones I, Arm JP, Strieter RM, Sabo R, Gunawardena KA. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 13. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Alexander ES, Martin LJ, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014 Sep 1. *Participated in enrolling patients in the study and acquisition of data.
Sampson H, Aceves S, Bock A, James J, Jones S, Lang D, Nadeau KC, Nowak-Wegrzyn A, Oppenheimer J, Perry T, Randolph C, Sicherer S, Simon R, Vickery B, and Wood R. Food Allergy: A practice parameter update-2014. J. of Allergy and Clinical Immunology. 2014 Aug. E publication. *Participated in design of parameters, material support, and review of data.
Manohar M and Nadeau KC. The Potential of anti-IgE in Food Allergy Therapy. Current Treatment Options in Allergy. 2014 Jun 1;1(2):145-156
Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. J Expo Sci Environ Epidemiol. 2014 Jun 18. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
McKenzie RB, Berquist WE, Nadeau KC, Louie CY, Chen SF, Sibley RK, Glader BE, Wong WB, Hofmann LV, Esquivel CO, Cox KL. Novel protocol including liver biopsy to identify and treat CD8+ T-cell predominant acute hepatitis and liver failure. Pediatr Transplant. 2014 Jun 14. *Participated in conception and design, enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Begin P, Chinthrajah RS, Nadeau KC. Oral immunotherapy for the treatment of food allergy. Hum Vaccin Immunother. 2014 Jun 5;10(8).
Begin P and Nadeau KC. Epigenetic regulation of asthma and allergic disease. Allergy, Asthma, and Clinical Immunology. 2014 May 28;10 (1):27.
Otani IM, Bégin P, Kearney C, Dominguez TL, Mehrotra A, Bacal LR, Wilson S, Nadeau KC. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol. 2014 May 12;10(1):25.
Jones PP, Nadeau KC. Introduction to the special issue on Stanford Immunology. Immunol Res. 2014 May;58(2-3):161-3.
Pellerin L, Jenks JA, Bégin P, Bacchetta R, Nadeau KC. Regulatory T cells and their roles in immune dysregulation and allergy. Immunol Res. 2014 May;58(2-3):358-68.
Klingbeil EC, Hew KM, Nygaard UC, Nadeau KC. Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res. 2014 May;58(2-3):369-73.
Bégin P, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Tavassoli M, Hoyte E, O'Riordan G, Blakemore A, Seki S, Hamilton RG, Nadeau KC. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy, Asthma, and Clinical Immunology. 2014 Feb 20;10(1):7.
Syed A, Garcia M, Kohli A, Maecker H, Tsai M, Galli S, and Nadeau KC. Peanut oral immunotherapy results in increased antigen-induced Treg function and hypomethylation of FOXP3. The Journal of Allergy and Clinical Immunology. 2014 Feb;133(2):500-10.
Kanai T, Jenks J, Seki S, Bacchetta R, and Nadeau KC. Identification of STAT5A and STAT5B Target Genes in Human T cells. PLoS One. 2014 Jan 30;9(1):e86790.
Bégin P, Winterroth LC, Dominguez T, Wilson SP, Bacal L, Mehrotra A, Kausch B, Trela A, Hoyte E, O'Riordan G, Seki S, Blakemore A, Woch M, Hamilton RG, Nadeau KC. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy, Asthma, and Clinical Immunology. 2014 Jan 15;10(1):1.

2013 Publications

Liu, J, Zhang, L, Winterroth, L, Garcia, M, Weiman, S, Wong, J, Sunwoo, J, and Nadeau, KC. Epigenetically-mediated pathogenic effects of phenanthrene on regulatory T cells. J Toxicol. 2013; 967-981.
Reber LL, Marichal T, Mukai K, Kita Y, Tokuoka SM, Roers A, Hartmann K, Karasuyama H, Nadeau KC, Tsai M, Galli SJ. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol. 2013 Oct;132(4):881-8. *Participated in obtaining funding, analysis and interpretation of data.
Syed A, Kohli A, and Nadeau KC. Food allergy diagnosis and therapy: where are we now? Immunotherapy. 2013 Sep; 5(9):931-44.
Chen R, Giliani S, Lanzi G, Mias GI, Lonardi S, Dobbs K, Manis J, Im H, Gallagher JE, Phanstiel DH, Euskirchen G, Lacroute P, Bettinger K, Moratto D, Weinacht K, Montin D, Gallo E, Mangili G, Porta F, Notarangelo LD, Pedretti S, Al-Herz W, Alfahdli W, Comeau AM, Traister RS, Pai SY, Carella G, Facchetti F, Nadeau KC, Snyder M, Notarangelo LD. Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias. J Allergy Clin Immunol. 2013 Sep;132(3):656-664. *Participated in acquisition of data, and analysis and interpretation of data.
Syed, A, Hew K, Kohli A, Knowlton G, Nadeau KC. Air Pollution and Epigenetics. Journal of Environmental Protection. 2013 Aug; 4:8A, 114-122.
Jenks JA, Seki S, Kanai T, Huang J, Morgan AA, Scalco RC, Nath R, Bucayu R, Wit JM, Al-Herz W, Ramadan D, Jorge AA, Bacchetta R, Hwa V, Rosenfeld R, Nadeau KC. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013 Aug;148(2):227-36.
Dominguez TL, Bégin P, Nadeau KC. The use of epinephrine in acute allergic reaction to food. Pediatric Annals. 2013 Jul;42(7):293-5.
Bégin P, Nadeau KC. Diagnosis of food allergy. Pediatr Ann. 2013 Jun 1;42(6):102-9.
Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, Chiang D, Umetsu DT, Nadeau KC. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol. Jun 2013;162(1):89-93
Ma J, Strub P, Lavori PW, Buist AS, Camargo CA Jr, Nadeau KC, Wilson SR, Xiao L. DASH for asthma: A pilot study of the DASH diet in not-well-controlled adult asthma. Contemporary Clinical Trials. 2013 May 3. *Participated in acquisition of data, analysis and interpretation of data, technical, and material support.
Le-Carlson M, Seki S, Abarbanel D, Quiros A, Cox K, and Nadeau KC. Markers of antigen presentation and activation on eosinophils and T-cells in the esophageal tissue of patients with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):257-62.
Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL. Immunomodulatory Effect of Vancomycin on Treg in Pediatric Inflammatory Bowel Disease and Primary Sclerosing Cholangitis. J Clin Immunol. 2013 Feb;33(2):397-406. *Participated in acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision of the manuscript for important intellectual content, technical support, material support, and statistical analysis.

2012 Publications

Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, and Nadeau KC. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7(11): p. 487-496.
Kanai T, Jenks J, Nadeau KC. The STAT5b pathway defect and Autoimmunity. Frontiers in Immunology. 2012; 3:234.
Kohli, A, Garcia, M, Miller, R, Maher, C, Humblet, O, Hammond, K, and Nadeau, KC. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. J. of Clinical Epigenetics. 2012 Sep 25;4(1):17. 2012.
Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012 Jul;130(1):215-224. (Recommended by Faculty 1000)
Yu GP, Weldon B, Neale-May S, Nadeau KC. The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial. Int Arch Allergy Immunol. 2012 Jun 1;159(2):179-182.
Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012 Jun;32(3):565-73.
Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, Schneider LC, Nadeau KC (co-senior author), Umetsu DT. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 2012 May;5(3):267-76.
Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr;19(2):284-8. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16;148(6):1293-307. *Participated in enrolling patients in the study, acquisition of data, and analysis and interpretation of data.
Recher M, Burns S, de la Fuente MA, Volpi S, Dahlberg C, Walter J, Moffitt K, Matthew D, Honke N, Lang, P, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau KC, Bouma G, Delmonte O, Frugoni F, Fomin A, Buchbinder D, Lundequist E-M, Massaad MJ, Tsokos G, Hartwig J, Manis J, Terhorst C, Geha R, Snapper S, Lang K, Malley R, Westerberg L, Thrasher A, Notarangelo L. B-cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22;119(12):2819-28. *Participated in enrolling patients in the study, and analysis and interpretation of data.
Pedroza L, Kumar V, Mace E, Nadeau KC, Perez E, Ruuskanen O, Orange J. AIRE contributes to Dectin-1-induced TNF-a production 1 and complexes with CARD9, Syk, and Dectin-1. J Allergy Clin Immunol. 2012 Feb;129(2):464-72. *Participated in enrolling patients in the study and analysis and interpretation of data.
Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT. Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Immunol Allergy Clin North Am. 2012 Feb;32(1):111-33.

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