The Alexander Laboratory's research focuses on understanding the fundamental mechanisms of amyloid formation and deposition in transthyretin amyloidosis (ATTR).
Our goal is to investigate the key molecular pathways connected to ATTR and to aid in the development of next-generation therapies for ATTR patients from bench to bedside. We've been concentrating on three important areas:
Establishing in vivo and in vitro models of ATTR amyloidosis;
Identifying novel mechanisms underlying the development of ATTR cardiac amyloidosis cardiomyopathy;
Conducting clinical and translational studies in ATTR patients to elucidate determinants and early signs of ATTR amyloidosis.
Our research has been published in several high-quality scientific journals, including Circulation, Circulation Heart Failure, Nature Review Cardiology, JAMA Cardiology, JACC CardioOncology, and Journal of Molecular and Cellular Cardiology.