Stanford ADRC Neuropathology Core

In support of research on Alzheimer disease and related disorders, the Neuropathology Core analyzes tissues and other biological samples from volunteers in the Stanford Alzheimer’s Disease Research Center (ADRC). Core faculty provide state of the art neuropathology diagnoses of ADRC participants according to consensus diagnostic criteria.  They contribute anonymous autopsy data to the National Alzheimer Coordinating Center, and prepare a brain autopsy report for a participant’s next of kin.  The Neuropathology Core maintains an archive of research tissues from ADRC brain autopsies. 

Maria Inmaculada Cobos Sillero MD, PhD
Assistant Professor of Pathology
Neuropathology Core Leader

Inma received her medical and doctoral degrees from the University of Murcia in Spain and completed post-doctoral training in Developmental Neurobiology at the University of California, San Francisco. She then pursued a clinical residency and fellowship in Anatomic Pathology and Neuropathology at Massachusetts General Hospital, Harvard Medical School. Before joining Stanford, she was an Assistant Professor in the Department of Pathology and Neuropathology at the UCLA David Geffen School of Medicine.

Her research program combines her background in diagnostic neuropathology, knowledge of developmental neuroscience, and state-of-the-art cellular and molecular technologies to advance the understanding of Alzheimer’s disease and related dementias. She is currently applying single-cell methods to human brain to dissect the contributions of distinct cell types to Alzheimer’s disease pathogenesis and investigate the mechanisms of tau-mediated neurodegeneration in human brain. Her work is supported by the NIH National Institute of Aging (R01), the Alzheimer’s Association, and BrightFocus. She recently received the Ben Barres Early Career Acceleration Award from the Chan Zuckerberg Initiative (CZI).

Donald Born, MD, PhD
Clinical Professor of Pathology

Dr. Born received his medical degree and PhD from the University of Virginia, and he trained in pathology and neuropathology at the University of Washington.  He is a senior anatomic neuropathologist with considerable experience in the evaluation and assessment of Alzheimer’s disease, Parkinson’s disease and other neurodegenerative disorders.

Birgitt Schüle, MD
Associate Professor of Pathology
Neuropathology Core Associate Leader

Birgitt Schüle, MD, is an Associate Professor in the Department of Pathology, Stanford University School of Medicine. Her research focuses on medical genetics and stem cell modeling to unlock disease mechanisms and pathways leading to neurodegeneration in Parkinson’s disease and related disorders, and to develop new therapeutic strategies to advance precision medicine.

She received her medical training from the Georg-August University Göttingen and Medical University Lübeck, Germany (1993 - 2001) and completed doctoral degree in medicine (Dr. med.) in neurophysiology at the Georg-August University Göttingen (2001). During her neurology internship from 2001 to 2002 at Medical University of Lübeck with Prof. Christine Klein, Dr. Schüle studied genes for inherited forms of Parkinson’s disease and dystonia. From 2003 to 2005, she completed a postdoctoral fellowship in human genetics with Prof. Uta Francke at Stanford University School of Medicine. From 2005-2019, Dr. Schüle led key clinical research programs and biospecimen repositories for neurogenetics, translational stem cell and brain donation at the Parkinson’s Institute and Clinical Center.

Hannes Vogel, MD
Professor of Pathology and of Pediatrics (Pediatric Genetics)

Dr. Vogel is associate chair for neuropathology in the Department of Pathology.  His research interests include mitochondrial diseases, nerve and muscle pathology, pediatric neuro-oncology, and transgenic mouse pathology.  He received his medical degree from the Baylor College of Medicine and completed residency and fellowship training in pediatrics, anatomic pathology, and neuropathology at Baylor, UCSF, Beth Israel Deaconess Medical Center, Stanford University, and Texas Children’s Hospital.

James Kelbert, BA
Autopsy Coordinator
Clinical Research Coordinator Associate

James Kelbert received his Bachelor of Arts in both Neuroscience and Spanish from Pomona College in 2020. He contributed to research in the UCLA David Geffen School of Medicine and in the UC Davis Department of Emergency Medicine. Within the ADRC, he coordinates brain donations and autopsies for ADRC participants and for volunteers in the Stanford Brain Bank Program. In this key role, he works closely with faculty and staff in the Clinical Core and Neuropathology Core.

Angela Elizabeth Madira
Neuropathology Coordinator

Angela graduated from Cal State LA in 2017 with a major in Biochemistry and a minor in Biology, while focusing on Neuroscience research. After graduation, she attended the University of Cambridge as a Gates-Cambridge scholar to pursue an MPhil in Health, Medicine, and Society. She worked as an EMT during the pandemic before joining Stanford’s Neuropathology Department under Dr. Inma Cobos.

Research Programs