Stanford Alzheimer's Disease Research Center Clinical Trials and Research Studies

Research Studies affiliated with the Stanford ADRC

Healthy Brain Aging Study

Goal: The Healthy Brain Aging Study refers to research undertaken by the Stanford Alzheimer’s Disease Research Center (ADRC). The Stanford ADRC is part of a nationwide network of congressionally mandated Centers of Excellence supported by the National Institutes of Health (NIH). We study people with Alzheimer’s disease, mild cognitive impairment, Lewy body disease, Parkinson’s disease, and normal cognition (healthy brain aging). The goal is to obtain information on factors that affect the risk of Alzheimer’s disease and related disorders and to find out how healthy brain aging differs from disorders like Alzheimer’s disease and Parkinson’s disease. The study collects information on medical history and family history. Data collection often includes questionnaires, memory testing, a blood sample, a brain scan, a stool sample, a very small (3 millimeter) skin biopsy, and spinal fluid examination. Not everyone can do all these studies, but we ask participants to consider these when possible. The Healthy Brain Study follows volunteers over time, and many participants consider brain donation at the time of death. Brain donation provides a definitive diagnosis and provides tissues for scientific research.
Sponsor:
 The NIH National Institute on Aging (grant no. P30 AG066515)
PI:
 Victor Henderson, MD, MS
Study status: Actively recruiting
Contact: 
Veronica Ramirez or Isabelle Yi 
vramirez1@stanford.edu or isabelleyi@stanfordhealthcare.org
(650) 721-5354 or (650) 721-2409

Pacific Udall Center

Goal: The Pacific Udall Center is part of a nationwide network of Centers of Excellence for Parkinson’s Disease Research supported by the National Institutes of Health. Udall Centers conduct research into the causes of Parkinson’s disease and Parkinson’s disease diagnosis and treatment. Many volunteers co-enroll in the Stanford ADRC, and protocols of the Pacific Udall Center and the Stanford ADRC are closely aligned with each other.
Sponsor:
 The NIH National Institute on Neurological Disease and Stroke (grant no. P50 NS062684)
PI: Tom Montine, MD, PhD and Kathleen Poston, MD, MS
Study status: Actively recruiting
Research coordinator: Maria-Lucia Campos
udallcenter@stanford.edu

(650) 721-5351

Stanford Alzheimer’s Disease Research Center (ADRC) Veterans supplement award

Goal: To increase Veteran recruitment into research programs of the Stanford ADRC and other NIH studies.
Sponsor:
 The NIH National Institute on Aging (grant no. 3P30 AG066515-01S1)
PI:
 Victor Henderson, MD, MS
Study status: 
Actively recruiting (Veterans only)
Research coordinator:
 Veronica Ramirez
vramirez1@stanford.edu

Alzheimer Gut Microbiome Project (AGMP)

Goal: To understand the role of the gut microbiome derived from stool samples in relation to Alzheimer disease.
Sponsor: 
 The NIH National Institute on Aging (grant no. U19 AG063744) and Duke University
PI:  Ami Bhatt, MD, PhD and Victor Henderson, MD, MS
Study status: Recruit occurs through the Stanford ADRC

Asian Cohort for Alzheimer’s Disease (ACAD)

Goal: To study the genetics of Alzheimer’s disease in people of Chinese ancestry (Mandarin- or English-speaking).  Eligible ACAD participants are encouraged to co-enroll in the Stanford ADRC.
Sponsor: 
 The NIH National Institute on Aging (grant no. R56 AG069130) and the University of Pennsylvania
PI:  Victor Henderson, MD, MS
Study status: Actively recruiting
Research coordinator:
 Isabelle Yi
IsabelleYi@stanfordhealthcare.org
(650) 721-2409

Auracle.  An AI-enabled telecare system to support the independence and safety of individuals with AD/ADRD and other dementias

Goal: To develop a home-based telecare system that uses artificial intelligence to promote the independence and safety of people with dementia.
Sponsor: 
 The NIH National Institute on Aging (grant no. R44 AG046969) and Gen Nine, Inc.
PI:  Abby King, PhD
Study status: Recruiting
Research coordinator: 
Dulce Garcia
dgarcia3@stanford.edu
(650) 463-6182

Development of a cost-effective and neurobiologically valid VR assessment tool for early detection of AD

Goal: To assess virtual reality measures in relation to MRI brain scan images to detect very early changes of Alzheimer’s disease.
Sponsor: 
 The NIH National Institute on Aging (grant no. R21 AG073973)
PI:  Hadi Hosseini, PhD
Study status: Recruiting
Research coordinator:
Samantha Reitmaier
mcik_study@stanford.edu
or samreit@stanford.edu
(650) 724-2939

Early Onset AD Consortium - the LEAD Study (LEADS)

Goal: To study the natural history of people with early-onset Alzheimer’s disease in order to improve diagnosis and assess biomarker progression.  LEADS participants are eligible to co-enroll in the Stanford ADRC.
Sponsor: 
 The NIH National Institute on Aging (grant no. U01 AGA057195) and Indiana University/Purdue University
PI:  Sharon Sha, MD, MS
Study status: Recruiting
Research coordinator
: Savneet Takhar, Amanda Ng
sktakhar@stanford.edu or amandang@stanford.edu
(650) 304-7428 or (650) 485-9560

Iron as an imaging biomarker for inflammation in Alzheimer’s disease

Goal: To learn how iron may be involved in Alzheimer’s disease through MRI and PET-MRI brain imaging.
Sponsor:
 NIH National Institute on Aging (grant no. R01 AG061120) and GE Healthcare
Status:
 Actively recruiting
PI:
 Michael Zeineh, MD
Research Coordinator:
 Nicole Mouchawar
nmouchaw@stanford.edu 
(650) 260-3026

Neighborhoods Study: Contextual disadvantage and Alzheimer's disease and related dementias

Goal: To evaluate how neighborhood disadvantage across the life span affects the risk of dementia (limited to Stanford ADRC participants).
Sponsor: 
 The NIH National Institute on Aging (grant no. R01AG070883) and the University of Wisconsin
PI:  Victor Henderson, MD, MS and Patricia Rodriguez Espinosa, PhD
Study status: Not recruiting
Research coordinator:
  Nicole Caceres

Palliative care needs and outcomes for dementia patients

Goal: In older adults with and without cognitive impairment, the goal is to study an early palliative care intervention.
Sponsor: 
 The NIH National Institute on Aging (grant no. R01 AG062239)
PI:
 VJ Periyakoil, MD
Study status:
Recruiting

Tool to identify Parkinson’s disease using digital facial expression biomarkers

Goal: To create a digital image of the face in people with early stages of Parkinson’s disease to help predict the severity and progression of Parkinson symptoms.
Sponsor: 
The Michael J. Fox Foundation for Parkinson’s Disease Research
PI: Kathleen Poston, MD, MS
Study status: Actively recruiting
Research coordinator:
 Kristen Wheeler
kjwheele@stanford.edu 
(650) 269-0484

Speaker-listener coupling and brain dynamics during naturalistic verbal communication in Alzheimer's disease

Goal: To study natural speech communication in Alzheimer’s disease using functional MRI brain imaging.
Sponsor: 
 The NIH National Institute on Aging (grant no. R21 DC017950-02S1)
PI:  Vinod Menon, PhD and Daniel Abrams, PhD
Study status: Actively recruiting
Research coordinator:
Viki Pratuseviciute
viki.pratu@gmail.com
(669) 649-3383

Tau PET brain imaging in Parkinson’s disease

Goal: To study tau pathology in relation to aspects of brain inflammation (TREM2), cognition, and behavior.
Sponsor:
 The NIH National Institute on Neurological Disease and Stroke (grant no. R01 NS115114)
PI: Kathleen Poston, MD, MS
Study Status: Actively recruiting
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu 
(650) 723-0060 

Clinical Trials

The Stanford Neurosciences Clinical Trials Team conducts clinical trials supported by industry, foundations, and the federal government.  Additional information is available at ClinicalTrials.gov and through the following link:  https://med.stanford.edu/neurology/research/clinicaltrials.html