Stanford Alzheimer's Disease Research Center Clinical Trials

Pacific Udall Center

Sponsor: NIH/NINDS Morris K. Udall Center of Excellence for Parkinson's Disease Research
PI: Tom Montine, MD, PhD
Study status: Open, Enrollment ongoing
Research coordinator: Meagan Adams, BS
udallcenter@stanford.edu
  650-721-5274

Healthy Brain Aging Study

This is a longitudinal study enrolling individuals with Alzheimer’s disease, Mild Cognitive Impairment, Lewy Body Dementia, Parkinson’s disease, Parkinson’s disease with dementia and healthy volunteers. It is funded by the National Institute of Health and is part of the Alzheimer’s Disease Research Center (ADRC). This study will collect data including medical history, family history and medication. There will be questionnaires to be filled out, cognitive testing and MRI of the brain. This study will follow participants over time.
Status:
Active recruiting
PI:
Victor Henderson, MD
CO-PI:
Tony Wyss-Coray, PhD
Status: Open, enrollment ongoing
Research coordinator: Christina Wyss-Coray
memoryresearch@stanford.edu
(650) 724-8736

High Resolution Imaging of Hippocampal Mechanisms in Age-Related Memory Decline

This study will enroll healthy older adults without memory complaints to better understand the processes and mechanisms of memory that change as we age.
Status: Active recruiting
PI:  Anthony Wagner, PhD
Research coordinator: Manasi Jayakumar
agingstudy@stanford.edu, (650) 498 0444

Structural Correlates of Cognitive and Motor Dysfunction in Parkinsonian Disorders

Status: Enrollment closed, analysis ongoing
PI: Kathleen Poston, MD, MS
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060 

Development of Multimodal Imaging Biomarkers for Cognitive Dysfunction in Parkinson's Disease

Sponsor: The Michael J. Fox Foundation for Parkinson’s disease Research
PI: Kathleen Poston, MD, MS
Study status: Enrollment closed, analysis ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060 

Functional Networks in Parkinson's Disease - an fMRI Activation and Functional Connectivity Study

Sponsor: NIH/NINDS
PI: Kathleen Poston, MD, MS
Study Status: Enrollment closed, analysis ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060 

A Phase 1/2 Trial Assessing the Safety and Efficacy of Bilateral Intraputaminal and Intranigral Administration of CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN]) in Subjects With Idiopathic Parkinson’s Disease

Clinical Trials Protocol #: NCT00400634
Sponsor: Sangamo Biosciences, Inc
Site PI: Kathleen Poston, MD, MS
Study Status: Closed, publication available
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060 

Early Differential Diagnosis of Parkinsonism with Metabolic Imaging and Pattern Analysis

Sponsor: NIH/NINDS and The Michael J. Fox Foundation for Parkinson’s disease Research
Site PI: Kathleen Poston, MD, MS
Study status: Enrollment Closed, analysis ongoing
Research coordinator: Marian Shahid, MSc
mshahid@stanford.edu (650) 723-0060 

IDEAS: Imaging Dementia-Evidence for Amyloid Scanning

An observational, open-label, longitudinal cohort study designed to assess the impact of amyloid PET on patient-oriented outcomes in Medicare beneficiaries with mild cognitive impairment (MCI) or dementia of uncertain etiology
Status
: Open for Enrollment, 65 years old and older, Medicare beneficiary
PI: 
Sharon J. Sha, MD MS
memoryresearch@stanford.edu
(650) 724-8736
NCT02420756

PET/MRI of Neurological Disease

The purpose of the study is to identify novel metrics for these imaging markers when they are acquired simultaneously as compared to the current standard of sequential imaging
PI: Greg Zaharchuk, MD, PhD
Status
: Open for Enrollment
Research Coordinator
: Sia Boumis
siaboumis@stanford.edu
,  650-245-7454

Simultaneous Acquisition of PET and MRI for Brain Imaging

The overall goal of this project is to determine the relationships among the different brain imaging biomarkers
P.I.
: Minal Vasanawala, MD
Status
: Open for Enrollment
Clinical Research Coordinator
: Sia Boumis
siaboumis@stanford.edu
, 650-245-7454

A Study to Evaluate the Efficacy and Safety of RO7105705 in Patients With Prodromal to Mild Alzheimer's Disease

A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, And Safety Study Of MTAUtau9937Aa In Patients With Prodromal to Mild Alzheimer's Disease (TAURIEL STUDY)
Status: Closed to enrollment, study activities continuing

PI: Sharon J. Sha, MD MS (NCT03289143)
Research coordinator: Jenn Gaudioso
Contact: jenn.gaudioso@stanford.edu

Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease (TANGO STUDY)

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Safety, Tolerability, and Efficacy of BIIB092 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild Alzheimer's Disease
Status: Closed to enrollment, study activities continuing
PI:
 Sharon J. Sha, MD MS (NCT03352557)
Research coordinator: Nischal Archarya
Contact: nishcal_acharya@stanford.edu

A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Subjects With Early Alzheimer's Disease (MissionAD2 Study)

A Placebo-Controlled, Double-Blind, Parallel-Group, 24-Month Study to Evaluate the Efficacy and Safety of E2609 in Subjects with Early Alzheimer's Disease
Status: Closed to enrollment, study activities continuing
PI:
 Sharon J. Sha, MD MS (NCT03036280)
Research coordinator:
Hanna Balcha
Contact:
hannafb@stanford.edu

Clinical Trials Contact