The world’s largest longitudinal population-based study of immunology and aging


The Stanford 1000 Immunomes Project (KIP) is a collaborative ongoing study at Stanford University that aims to define the biological basis of aging and disease using state-of-the-art ‘omics’ platforms and advanced artificial intelligence (AI) methods.

The main focus of 1KIP is to establish biomarkers for healthy versus sub-functional immune systems. We do this by identifying the interactions between genetic and environmental factors, which contribute to the observed heterogeneity of biological responses in human beings. To this end, 1000 individuals of different age groups (9-96 years old) were recruited between 2007-2017. Their blood samples were screened using multiple state-of-the-art technologies at a single facility, the Human Immune Monitoring Center (HIMC) to measure circulating proteins, cell types, cellular functions, whole-genome blood gene expression and subjects' haplotypes using deep sequencing technologies.

The 1KIP dataset has enabled us for the first time to identify reliable biomarkers of aging and disease in a longitudinal population-based study of immunology and aging. 1KIP provides reference values for thousands of immune variables and identifies clusters of individuals sharing similar health versus disease immune profiles.


1KIP is supported by:

Human Immune Monitoring Center (Stanford University)

Stanford-LPCH Vaccine Program (Stanford University)

Twin Research at SRI International (Menlo Park, CA)

National Institute of Health

Howard Hughes Medical Institute

Stanford Center on Longevity

Ellison Medical Foundation