Yoon Lab  

  Research on Schizophrenia and Related Conditions


Detail from 'Dopamine D2 Receptor' ©Neil Murphy

 

Adults between the ages of 16-55 with schizophrenia or a related disorder:

We are looking for individuals to participate in a study on psychosis and schizophrenia that looks at memory, attention, and information processing. Subjects must have no major medical or neurologic illness, or significant substance abuse.

Participants will serve as subjects for experiments including interviews, computer testing, functional magnetic resonance imaging (fMRI), and/or electroencephalography (EEG).

Individuals will participate in interviews, cognitive testing, magnetic resonance imaging (MRI), and other related tasks. Participants will receive $15 to $30 per hour depending on the task.

If interested, please call the Yoon Lab at (650) 849-1930 or email us at
brain-research@stanford.edu. A confidential phone screen will be conducted to determine your initial eligibility.

Principal Investigator: Jong Yoon, M.D.
Study Contact: Daniel Virtheim

For general information about participants’ rights, contact the Stanford IRB at 1-866-680-2906

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The Yoon Lab seeks to discover the brain mechanisms responsible for schizophrenia and to translate this knowledge into the clinic to improve how we diagnose and treat this condition. Towards these ends, our group has been developing cutting-edge neuroimaging tools to identify neurobiological abnormalities and test novel systems-level disease models of psychosis and schizophrenia directly in individuals with these conditions.

We have been particularly interested in the role of neocortical-basal ganglia circuit dysfunction. A working hypothesis is that some of the core symptoms of schizophrenia are attributable to impairments in neocortical function that results in disconnectivity with components of the basal ganglia and dysregulation of their activity. The Yoon Lab has developed new high-resolution functional magnetic resonance imaging methods to more precisely measure the function of basal ganglia components, which given their small size and location deep within the brain has been challenging. This includes ways to measure the activity of nuclei that store and control the release of dopamine throughout the brain, a neurochemical that is one of the most important factors in the production of psychosis in schizophrenia and other neuropsychiatric conditions.

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Prodromal/At-Risk Research Studies
Studies for Healthy Research Subjects

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