Welcome to Dr. Yunzhi Peter Yang’s Group at Stanford University.

Globally, musculoskeletal diseases and trauma have an estimated cost of US$950 billion annually, placing a significant economic burden on national healthcare systems. Musculoskeletal ailments severely impact mobility, dramatically reducing the quality of life for patients, especially the elderly. Regenerative medicine and tissue engineering hold great promise to improve the treatment of these diseases and trauma as well as to restore lost functions. Despite great progress in the past twenty years, we have gradually come to the consensus that the great complexity of tissue regeneration requires we approach problems in a systematic way in order to make breakthroughs. Currently, there are still three fundamental questions in tissue engineering that hinder translation and clinical success, including how to recreate microenvironments to control cell fate, how to promote vascularization for cell viability, and how to harness stem cells as cell source. More specifically, regarding microenvironments, how do we engineer a microenvironment to include both scaffold and signals, or accurately manipulate 3D biochemical, biophysical, biomechanical, bioelectrical and biomagnetic cell cues in a temporal and spatial manner to accelerate tissue regeneration and healing? Second, regarding vascularization, how do we meet the functional microvasculature requirement in which the distance between an individual cell and the nearest capillary vessels cannot be more than 100-300 μm or else the cell will suffer from insufficient nutrition and oxygen? Third, regarding stem cells, what is the origin of stem/progenitor cells and how fast and how many stem/progenitor cells can grow in a clinically relevant setting? In our lab, we use bio-inspired approaches to systematically address these challenges by integrating the expertise in materials science and engineering, chemistry, bone and stem cell biology, and orthopedic surgery.

News

  • July 2020: Congratulations to Dr. Alexander Martin Stahl  for successfully defending his PhD thesis (photos) !
  • June 2020: Drs. Stephen Palumbi, Bo Wang and Yunzhi Peter Yang received a grant from the Stanford Woods Institute for the Environment for identifying factors that affect coral reef’s resistance to bleaching using Yang lab’s newly developed high throughput bioprinting platform.
  • May 2020: Congratulations to Dr. Chi-chun Jerry Pan for successfully defending his PhD thesis (photos)!
  • May 2020: Drs. Yunzhi Peter Yang, and Emilie Cheung have received a three-year grant from the Department of Defense to study tendon regeneration! 
  • March 2020: Dr. Yunzhi Peter Yang has been inducted into the College of Fellows, Class of 2020  of American Institute for Medical and Biological Engineering (AIMBE) https://aimbe.org/press/yang-COF-5141.pdf
  • June 2019: Dr. Yunzhi Peter Yang’s Science Perspective on “Ruminants: Evolutionary past and future impact” and Wired Story in his research in deer antler regeneration are published. 
  • February 2019: Drs. Yunzhi Peter Yang, William Maloney, and Geoffrey Gurtner have received a five-year grant from the National Institutes of Health to study vascularization of tissue engineering bone constructs! 
  • November 2018: A decade-long research effort in deer antler stem cells at the Yang lab led to the first publication in Stem Cell Research & Therapy, which is featured by New York Times, and Telegraph!
  • August 2018: Dr. Yang and Dr. Goodman have received a five-year grant from the National Institutes of Health to study the novel tissue engineering approach to improve the treatment of early stage of osteonecrosis of the femoral head! 
  • June 2018: Dr. Yang’s Hybprinter 3D printing platform technology received the 2018 TechConnect Innovation Award, one of the two awardees from Stanford University!
  • January 2017: Yang lab technology is in the news, which could be the first alternative to the estimated 100,000 surgeries carried out in the US every year!