Welcome to Dr. Yunzhi Peter Yang’s Group at Stanford University.

Globally, musculoskeletal diseases and trauma have an estimated cost of US$950 billion annually, placing a significant economic burden on national healthcare systems. Musculoskeletal ailments severely impact mobility, dramatically reducing the quality of life for patients, especially the elderly. Regenerative medicine and tissue engineering hold great promise to improve the treatment of these diseases and trauma as well as to restore lost functions. Despite great progress in the past twenty years, we have gradually come to the consensus that the great complexity of tissue regeneration requires we approach problems in a systematic way in order to make breakthroughs. Currently, there are still three fundamental questions in tissue engineering that hinder translation and clinical success, including how to recreate microenvironments to control cell fate, how to promote vascularization for cell viability, and how to harness stem cells as cell source. More specifically, regarding microenvironments, how do we engineer a microenvironment to include both scaffold and signals, or accurately manipulate 3D biochemical, biophysical, biomechanical, bioelectrical and biomagnetic cell cues in a temporal and spatial manner to accelerate tissue regeneration and healing? Second, regarding vascularization, how do we meet the functional microvasculature requirement in which the distance between an individual cell and the nearest capillary vessels cannot be more than 100-300 μm or else the cell will suffer from insufficient nutrition and oxygen? Third, regarding stem cells, what is the origin of stem/progenitor cells and how fast and how many stem/progenitor cells can grow in a clinically relevant setting? In our lab, we use bio-inspired approaches to systematically address these challenges by integrating the expertise in materials science and engineering, chemistry, bone and stem cell biology, and orthopedic surgery.

News

  •  
  • February 2019: Drs. Yunzhi Peter Yang, William Maloney, and Geoffrey Gurtner have received a five-year grant from the National Institutes of Health to study vascularization of tissue engineering bone constructs! 
  • December 2018: Dr. Yang has been invited to give a webinar on 3D Printing Platform and 3D Printed Scaffolds for Bone Tissue Engineering hosted by the Society of Materials Research for the Focus Issue of 3D Printing of Biomaterials of the Journal of Materials Research!
  • November 2018: A decade-long research effort in deer antler stem cells at the Yang lab led to the first publication in Stem Cell Research & Therapy, which is featured by New York Times, and Telegraph!
  • October 2018: Dr. Yang has served as the co-track chair of the Orthopedic and Rehabilitation Engineering for the 2018 Biomedical Engineering Society Annual Meeting! 
  • August 2018: Dr. Yang and Dr. Goodman have received a five-year grant from the National Institutes of Health to study the novel tissue engineering approach to improve the treatment of early stage of osteonecrosis of the femoral head! 
  • June 2018: Dr. Yang’s Hybprinter 3D printing platform technology received the 2018 TechConnect Innovation Award, one of the two awardees from Stanford University!
  • May 2018: Dr. Yang gave an invited talk in 3D bioprinting platform technology and 3D printed medical devices in the workshop hosted by Advanced Regenerative Medicine Institute (ARMI)! 
  • December 2017: Dr. Yang has been invited to give a talk in Bioprinting for vascularized composite musculoskeletal tissue engineering in Kavli Workshop hosted by the Material Research Society!
  • October 2017: Dr. Yang has been invited to give a talk in the 15th Annual Symposium on Biomaterials Science with the theme of Pharmaceutical Biomaterials & Regenerative Medicine: From Concept to Manufacturing!
  • January 2017: Yang lab technology is in the news, which could be the first alternative to the estimated 100,000 surgeries carried out in the US every year!