Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the architecture and dynamics of intercellular adhesion junctions, signaling pathways that govern cell fate determination, and determinants of cell polarity. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.
Structural Biology, founded in the 1970’s as the first of its kind in the United States, is a world leader in the molecular and structural understanding of biology. The discipline sits at the interface of physics, chemistry, and biology. Research in the department spans a wide range of biological problems at the molecular, cellular, tissue, and whole animal scales, and includes the molecular basis of transcription and translation, cellular signaling, development of multicellular tissues, virus structural biology, immunology, and computational biology.