Clinical Trials

Current Studies

The following are current vaccine clinical trials conducted by the Stanford-LPCH Vaccine Program. For more information about clinical trials and a nationwide database of clinical trials, please go to ClinicalTrials.gov.

For general information about participant rights, contact 1-866-680-2906.

Our clinic location is at 800 Welch Road, Palo Alto, CA 94304. General telephone number: (650) 498-7284.

Seasonal Flu Vaccine Studies
We have several seasonal flu vaccine studies each year in the fall. Find your age below to be directed to the appropriate trials:


Genetic and Environmental Factors in the Response to Influenza Vaccination; SLVP028 (Twin Study)

The Stanford-LPCH Vaccine Program is seeking healthy twins, 12-49 years old to take part in an influenza vaccine study (commonly known as "the flu"). We hope to understand the cell responses to influenza vaccination in Monozygotic (MZ) and Dizygotic (DZ) twins to determine the roles of genetic and environmental in the response to vaccination.

The flu vaccine used in this study is licensed by the FDA and is not experimental. The research will be conducted at Stanford University by Cornelia L. Dekker, MD, Professor of Pediatrics, William Hewitt Robinson, MD, PhD, Associate Professor of Medicine/Immunology & Rheumatology, and Catherine Blish, MD, PhD, Assistant Professor of Medicine. The trial is sponsored by the National Institutes of Health.

To be eligible you should be:

  • Generally Healthy
  • 12-49 years old, and an identical or fraternal twin
  • Able to attend 3 clinic visits at Stanford
  • Able to provide 3 blood samples

 

If eligible, you will receive:

  • Current licensed seasonal flu vaccine
  • $50 per clinic visit attended plus mileage
  • Parking vouchers

 

Eligibility:

To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link:  Eligibility Criteria and Visit Schedule.

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu


Innate and Acquired Immunity to Influenza Infection and Immunization (B-cell Study; SLVP029)

The purpose of this NIH-sponsored clinical trial is to provide a better understanding of the natural and adaptive immune response to the flu virus and to compare the immune cell responses to flu vaccine in nasal mucosal cells and in blood. We hope the information learned from this study will help identify and describe important factors of influenza immunity especially B-cell responses at different stages of life especially during infancy and possibly lead to the development of more effective vaccines.

Volunteers will receive one of two FDA-licensed influenza vaccines, either the inactivated vaccine given as a flu shot, or the live, attenuated vaccine given as a nasal spray. These are the same seasonal flu vaccines that are used for the public during the flu season.

The research will be conducted at Stanford University by Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection), and Harry Greenberg, MD. Senior Associate Dean of Research.

We are enrolling children and adults for this study. To be eligible you or your child must be:

  • Healthy and 6 month-4 years of age, 9-13 years or 18-49 years old
  • Able to come for 2-4 visits at Stanford and provide either a blood sample and/or nasal swab sample.

 

For your participation, you will receive $30.00 compensation for each completed visit and parking vouchers for clinic visits.

Eligibility: To review the complete list of eligibility requirements and to learn more about the visit schedule for this study, please click this link:  Eligibility Criteria and Visit Schedule  

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu


The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection (T-cell Study; SLVP030)

The purpose of this NIH-sponsored clinical trial is to provide a better understanding of the developing immune system by studying the response to the licensed flu vaccine. We hope the information learned from this study will help identify and describe important factors of immunity, especially T-cell responses in the early stages of life. This knowledge may lead to the development of more effective vaccines.

Your child will receive the FDA-licensed inactivated influenza vaccine given as a flu shot. This is the same seasonal flu vaccine that is used for the public during the flu season.

We are enrolling children for this study. To be eligible your child must be:

  • Healthy 6 months-10 years of age or identical twins 2-5 years of age.
  • Able to come for 2-3 visits at Stanford and provide a blood sample.

 

For your participation, you will receive $30.00 compensation for each completed visit and parking vouchers for clinic visits.

For further information or to volunteer:
Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284
or email us at Vaccines_Program@stanford.edu


Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort (SLVP033) 

The Stanford-LPCH Vaccine Program is enrolling healthy adults who have participated in prior studies to take part in a study to examining how vaccine responses in the elderly differ from the responses of young adults. We will study three vaccines, each of which is will elicit a different type of immune response: influenza, Hepatitis A and Typhoid.

The extent and underlying reasons for impaired primary responses in older subjects are not well understood. The purpose of this study is to gain molecular and cellular mechanistic insights into the impaired vaccine responses in the elderly.

All of the vaccines used in this study are licensed by the FDA and are not experimental. Because we are interested in understanding how the immune response changes over time in the same individual, volunteers will be asked to participate annually through the end of the funding period.

The research will be conducted at Stanford University by Cornelia L. Dekker, M.D., Professor of Pediatrics at Stanford (Stanford-LPCH Vaccine Program), Scott Boyd, M.D., Ph.D. and Mark Davis, Ph.D. (Institute of Immunity Transplantation and Infection). The trial is sponsored by the National Institutes of Health.

To be eligible you should be:

  • Generally healthy and 18-40 or 65 or more years old
  • Able to attend clinic visits yearly at Stanford University
  • Able to provide 4 blood samples with each vaccination
  • Able to provide two stool samples

 

If eligible you will receive:

You will receive current licensed seasonal flu vaccine every fall, appropriate for your age.

You may also receive current licensed Hepatitis A vaccine and current licensed Typhoid vaccine in either an oral or injectable form.

Eligibility: The study is open to volunteers who have been previously enrolled in a prior SLVP flu vaccine study.

For further information: Please contact the Stanford-LPCH Vaccine Program at (650) 498-7284 or email us at Vaccines_Program@stanford.edu.