Research Projects

Targeted Microbubbles

In this project, we aim to develop novel beamforming techniques to improve the sensitivity of contrast-enhanced ultrasound (CEUS) imaging.  CEUS imaging techniques rely on the nonlinear response of microbubbles to ultrasound pressure waves in order to differentiate echoes originating from tissue and microbubbles.  However, the propagation of ultrasound in tissue creates nonlinear distortion too, so the pulse pressure must be kept low to avoid tissue signal leakage in the CEUS image.  This low pulse pressure results in low signal-to-noise ratio (SNR) of the CEUS image. This can be challenging for imaging targeted microbubbles, where the concentration of microbubbles may be much lower than in non-targeted imaging applications.


Juergen K. Willmann, M.D.

Juergen is the Clinical Chief of Body Imaging and a Professor in the Department of Radiology in the Stanford University Hospital and School of Medicine.  His research lab focuses on translational molecular imaging (read more here).

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Taehwa Lee, Ph.D.

Taehwa Lee is a post-doctoral research fellow in the Department of Radiology, Willmann/Translational Molecular Imaging Lab. He received the Ph.D. degree from the University of Michigan in 2015, with his work focusing on laser-generated ultrasound for cavitation and time-resolved optical imaging. His research interests include passive cavitation imaging, drug delivery, and therapeutic ultrasound.

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