Tang Lab In the Department of Genetics


Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, Quesenberry CP Jr, Rowell S, Sadler M, Sakoda LC, Sciortino S, Shen L, Smethurst D, Somkin CP, Van Den Eeden SK, Walter L, Whitmer RA, Kwok PY, Schaefer C, Risch N. Genetics. 2015 Jun 19.

Leveraging Multi-Ethnic Evidence for Mapping Complex Traits in Minority Populations: An Empirical Bayes Approach. Coram MA, Candille SI, Duan Q, Chan KHK, Li Y, Kooperberg C, Reiner AP, Tang H. American Journal of Human Genetics 2015 May 7;96(5):740-52.

Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families. Shetty PB, Tang H, Feng T, Tayo B, Morrison AC, Kardia SL, Hanis CL, Arnett DK, Hunt SC, Boerwinkle E; Candidate Gene Association Resource (CARe) Consortium, Rao DC, Cooper RS, Risch N, Zhu X.. Circ Cardiovasc Genet. 2015 Feb;8(1):106-13

Leveraging population admixture to characterize the heritability of complex traits. Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL. Nat Genet. 2014 Dec;46(12):1356-62.

The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function. Wang YJ, Tayo BO, Bandyopadhyay A, Wang H, Feng T, Franceschini N, Tang H, Gao J, Sung YJ; COGENT BP consortium, Elston RC, Williams SM, Cooper RS, Mu TW, Zhu X. PLoS Genet. 2014 Sep 18;10(9):e1004641.

Modeling 3D facial shape from DNA. Claes P, Liberton DK, Daniels K, Rosana KM, Quillen EE, Pearson LN, McEvoy B, Bauchet M, Zaidi AA, Yao W, Tang H, Barsh GS, Absher DM, Puts DA, Rocha J, Beleza S, Pereira RW, Baynam G, Suetens P, Vandermeulen D, Wagner JK, Boster JS, Shriver MD. PLoS Genetics. 2014; 10(3): e1004224.

Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative. Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N. Hum Mol Genet. 2014 Dec 15;23(24):6634-43. Epub 2014 Jul 15.

Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H. Am J Hum Genet. 2013 May 29. [Epub ahead of print]

Variation and genetic control of protein abundance in humans. Wu L, Candille SI, Choi Y, Xie D, Jiang L, Li-Pook-Than J, Tang H, Snyder M. Nature. 2013 May 15 [Epub ahead of print]

Genetic architecture of skin and eye color in an African-European admixed population. Beleza S, Johnson NA, Candille SI, Absher DM, Coram MA, Lopes J, Campos J, Araújo II, Anderson TM, Vilhjálmsson BJ, Nordborg M, Correia e Silva A, Shriver MD, Rocha J, Barsh GS, Tang H. PLoS Genetics. 2013; 9(3): e1003372.

Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations. Candille SI, Absher DM, Beleza S, Bauchet M, McEvoy B, Garrison NA, Li JZ, Myers RM, Barsh GS, Tang H, Shriver MD. PLoS One. 2012; 7(10):e48294.

Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. Reiner AP, Beleza S, Franceschini N, Auer PL, Robinson JG, Kooperberg C, Peters U, Tang H. Am J Hum Genet. 2012; 91(3):502-12.

Estimating kinship in admixed populations. Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N. Am J Hum Genet. 2012; 91(1):122-38.

Personal omics profiling reveals dynamic molecular and medical phenotypes. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Cell. 2012; 148(6):1293-307.

Human genetic variation altering anthrax toxin sensitivity. Martchenko M, Candille SI, Tang H, Cohen SN. Proc Natl Acad Sci U S A. 2012 ;109(8):2972-7.

Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). Carty CL, Johnson NA, Hutter CM, Reiner AP, Peters U, Tang H, Kooperberg C. Hum Mol Genet. 2012; 21(3):711-20.

Ancestral components of admixed genomes in a Mexican cohort. Johnson NA, Coram MA, Shriver MD, Romieu I, Barsh GS, London SJ, Tang H. PLoS Genet. 2011; 7:e1002410.

Joint testing of genotype and ancestry association in admixed families. Tang H, Siegmund DO, Johnson NA, Romieu I, London SJ. Genet Epidemiol. 2010; 34:783-91.

Characterizing the admixed African ancestry of African Americans. Zakharia F, Basu A, Absher D, Assimes TL, Go AS, Hlatky MA, Iribarren C, Knowles JW, Li J, Narasimhan B, Sidney S, Southwick A, Myers RM, Quertermous T, Risch N, Tang H. Genome Biol. 2009; 10 (12): R141

Molecular and evolutionary history of melanism in North American gray wolves. Anderson TM, vonHoldt BM, Candille SI, Musiani M, Greco C, Stahler DR, Smith DW, Padhukasahasram B, Randi E, Leonard JA, Bustamante CD, Ostrander EA, Tang H, Wayne RK, Barsh GS. Science. 2009; 323 (5919): 1339-43

Worldwide human relationships inferred from genome-wide patterns of variation. Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM. Science. 2008; 319 (5866): 1100-4

A statistical method for chromatographic alignment of LC-MS data. Wang P, Tang H, Fitzgibbon MP, McIntosh M, Coram M, Zhang H, Yi E, Aebersold R. Biostatistics. 2007; 8 (2): 357-67

Recent genetic selection in the ancestral admixture of Puerto Ricans. Tang H, Choudhry S, Mei R, Morgan M, Rodriguez-Cintron W, Burchard EG, Risch NJ. Am J Hum Genet. 2007; 81 (3): 626-33

Genomewide evolutionary rates in laboratory and wild yeast. Ronald J, Tang H, Brem RB. Genetics. 2006; 174 (1): 541-4

Reconstructing genetic ancestry blocks in admixed individuals. Tang H, Coram M, Wang P, Zhu X, Risch N. Am J Hum Genet. 2006; 79 (1): 1-12

A newly discovered founder population: the Roma/Gypsies. Kalaydjieva L, Morar B, Chaix R, Tang H. Bioessays. 2005; 27 (10): 1084-94

Estimation of individual admixture: analytical and study design considerations. Tang H, Peng J, Wang P, Risch NJ. Genet Epidemiol. 2005; 28 (4): 289-301

Ethnicity and human genetic linkage maps. Jorgenson E, Tang H, Gadde M, Province M, Leppert M, Kardia S, Schork N, Cooper R, Rao DC, Boerwinkle E, Risch N. Am J Hum Genet. 2005; 76 (2): 276-90

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork NJ, Risch NJ. Am J Hum Genet. 2005; 76 (2): 268-75

Locally weighted transmission/disequilibrium test for genetic association analysis. Hsu L, Yu X, Houwing-Duistermaat JJ, Uh HW, El Galta R, Lebrec JJ, Tang H. BMC Genet. 2005: 6 Suppl 1 S60


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