Faculty Courtesy Appointments
Member, National Academy of Sciences
Research Interest: Axel Brunger's goal is to understand the molecular mechanism of synaptic neurotransmission. He is particularly interested in the structure, function, and dynamics of key players in the synaptic vesicle fusion machinery. His lab is also working on the mechanism of action of clostridial neurotoxins that target this machinery. Other projects include the ATPases of the AAA family that are involved in protein complex disassembly and degradation. A molecular understanding of these complex protein m.
Research Interest: Many of the wonders associated with biomolecules rest in their functionality, but before they can carry out any function, many of these molecules must accomplish another amazing feat: them must first assemble themselves. Moreover, these molecules must build complex structures quickly and reliably. It is intriguing to consider how one can design molecules to self assemble. Actually, this is an extremely old problem: for billions of years, Nature has been honing its skills at molecular design. Can we benefit from Nature's billion year investment in the R & D of molecular self assembly?