If the antibody treatment is eventually found to be viable in humans, it could increase the numbers of people who benefit from hematopoietic stem transplants, Stanford researchers said.
Researchers at Stanford and the University of Tokyo may have cracked the code to doing stem cell transplants and gene therapy without radiation and chemotherapy.
In preclinical trials, Stanford scientists and their collaborators harnessed the gene-editing system CRISPR-Cas9 to replace the mutated gene underpinning the devastating immune disease.
An antibody to a protein on blood-forming stem cells may allow bone marrow transplants without the need for chemotherapy and radiation, according to a Stanford study.
Researchers’ experimental approach for preparing mice for blood stem cell transplantation may one day make it possible in humans to safely transplant organs or cells from any donor to any recipient.
Video: Viral DNA is crucial to human development
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