MicroRNAs are non-coding RNAs that regulate gene expression. Endogenous microRNA levels in the brain can be altered with chemically modified mimics and inhibitors, which then can alter downstream gene expression. We are exploring novel approaches using microRNAs to alter mitochondrial function for both acute and long-term therapies.
Glia, including astrocytes and microglia, are master regulators of neuronal function in health and in response to injury. We are targeting glial mitochondrial function as a novel approach for neuroprotection from stroke.
Neurotrophins are extracellular signaling molecules that shape the developing brain, but regulate neuronal homeostasis in the adult brain as well. We are revisiting these molecules in the context of downstream mitochondrial function following cerebral ischemia, with a focus on neuroglia cross-talk.