I am a clinical anesthesiologist and basic scientist. My goal is to develop new treatments to improve neurologic outcome following cerebral ischemia. Global cerebral ischemia, as occurs secondary to cardiac arrest, often results in profound cognitive disability secondary to hippocampal injury in survivors. Currently no pharmaceutical interventions exist to minimize injury and improve clinical outcomes. To overcome translational barriers, my focus is on non-coding RNAs, with potential to simultaneously target multiple related downstream gene pathways. MicroRNAs are endogenous, non-coding RNAs that modulate gene expression by silencing translation of target genes. My recent work demonstrates roles for several microRNAs in altering levels of injury and their therapeutic potential as drug targets in cerebral ischemia.
Yi-Bing Ouyang , PhD
Senior Research Scientist
I have more than 30 years research experience in cerebral ischemia research using in vitro cell culture models and in vivo rodent ischemic models. I have created animal models of cerebral ischemia and I helped adapt the forebrain ischemia model we currently employ in our laboratory for use in the proposed Aims. I have advanced expertise in gene therapy approaches, measuring cellular function in living cells, assessing pathological outcomes following in vitro ischemic stress, designing in vivo and in vitro experiments, and collecting and analyzing experimental data.
Xiaoyun Sun, MD
Lijun Xu, MD
Research Associate, Lab Manager
|Georgia Kaidonis, MD, PhD||Opthomology Residency @ UCSF||2017-2018|
|Jie Pan, MD||Neurology Residency @ Texas Tech||2018|
|Le Li, MD, PhD||2016-2017|
Visiting Graduate Students
|Sean||Med Student @ Queen's University at Kingston||2018|
|Ryan Buchanan||Stanford BioX||2017|
|Bhavana Kunisetty||Undergraduate Visiting Intern||2018|
High School Students