In addition to standard molecular and biochemical assays, we utilize several, in-house platforms to assess the real-time intracellular/mitochondrial response to injury during hypoxia, including:

NeurolucidaTM Software

Reliable co-localization, neuron tracing and reconstruction, neuron analysis, and 3D brain mapping

NeurolucidaTM 360

Automated neuron reconstruction in a 3-dimensional environment to obtain reliable data about the size, shape, and complexity of neurons.

In Vivo Models

Potential pre-clinical therapeutics are tested for efficacy in rodent models of cerebral ischemia, including transient middle cerebral artery occlusion (MCAO) and global forebrain ischemia.  Pathohistology, neuroimaging and behavioral outcomes provide clinical measures of efficacy.