Prof. Daniel Spielman award new 4-year NIH grant.
August 2015. NIH R01 EB019018, "Imaging Brain Metabolism Using MRS of Hyperpolarized 13C-Pyruvate"
Energy regulation and mitochondrial function are critically important for understanding brain metabolism in normal and diseased states. The overall goal of this technical development grant is to develop optimized methods for imaging brain energy utilization using in vivo using magnetic resonance spectroscopy of hyperpolarized 13C-pyruvate to assess glycolysis, oxidative phosphorylation, and mitochondrial metabolism. The successful completion of this project will provide a powerful new set of in vivo brain imaging tools with primary applications being assessing tumors, neurodegenerative and neuropathological disorders, and basic neuroscientific questions.