JULY 2003
Volume 27 No. 7

Emergency department expansion, renovation will enhance care

Leadership, teamwork pay off in successful trauma survey

Trauma program QI projects

Results of statewide hospital survey provide benchmarking data

New rules limiting residents' work hours will require increased efficiency

Lawyer and medical ethicist helps physicians, families navigate ethical dilemmas









Below are selected highlights of recent medical research
conducted at Stanford Medical Center.
Detailed news releases are available on the Internet at

COLON CANCER TREATMENT. Researchers at Stanford found that colon cancer patients treated with a combination of chemotherapy agents known as FOLFOX plus a new drug called Iressa showed improvement. In 16 patients who had never before received chemotherapy, 75 percent of the tumors shrank with the combination of Iressa and FOLFOX, compared with 38 percent in those who received only FOLFOX. In patients whose previous chemotherapy had not been successful, 29 percent of the tumors shrank compared with 9 percent in patients treated with FOLFOX alone. Stanford General Clinical Research Center director Branimir Sikic, professor of medicine (oncology), and colleagues presented these preliminary findings in June at the American Society of Clinical Oncology in Chicago..

DIAGNOSING ENDOMETRIOSIS. A new study using microarray technology to identify genes that contribute to endometriosis may lead to less-invasive diagnosis and improved treatment of the disease, which affects 10 to 15 percent of women of reproductive age and 35 to 50 percent of women with infertility. A screening of 12,868 genes performed at Stanford revealed that 91 genes had more than a twofold increase in gene expression in women with endometriosis compared with women without the disease, and 115 other genes showed more than a twofold decrease. Combining these findings and those of an earlier study, researchers zeroed in on genes that seem especially relevant, narrowing the field of genes that likely play a role in the development of endometriosis. The findings were reported in the July issue of Endocrinology by researcher Lee Kao and professor of obstetrics and gynecology Linda Giudice, along with colleagues elsewhere.

SHORT ON SLEEP. A pilot study on the effects of sleep deprivation found that although individual tolerance of sleep restriction varies widely, study participants who were limited to sleeping from 2:15 to 6:15 a.m. showed a better overall adaptation than members of a second study group who slept from 10:30 p.m. to 2:30 a.m. The researchers found that sleep deprivation affected all participants but that those in the early-morning sleep group had better rates of sleep efficiency (the percentage of time spent sleeping) and sleep latency (the amount of time spent falling asleep) than those in the late-night sleep group. The research, which appeared in the May issue of Sleep Medicine, was conducted by Christian Guilleminault, professor of psychiatry and behavioral sciences, and colleagues.