Gene Expression Analysis of Human Endotoxin Response
Endotoxin administration to healthy human volunteers elicits a classic inflammatory response by activating the innate immune system. We utilize an approach which combines genome-wide expression analysis with a network analysis base on literature mining to explore the diversity and magnitude of this acute inflammatory process.
Impact/Significance
Endotoxin response is a classic model for study of inflammation
Inflammation is the hallmark of many human diseases, being associated with cancer, cardiac disease and trauma
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Personnel SGTC Glue Grant Consortium |
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Accomplishments
Profiling of the temporal gene expression response to in vivo endotoxin administration in whole blood leukocytes as well as T-lymphocyte, monocyte and neutrophil populations.
Systems analysis to identify biological networks involved during activation and resolution of the process
