Special Seminar in Microbiology & Immunology "Microbiota-immune interaction in lung cancer"
Mar 04, 2019 (Mon) | 11:00 AM -12:00 PM
Munzer Auditorium/Beckman Center
: Stanford, CA
Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here we provide evidence that local microbiota provoke inflammation and lung cancer development by activating lung-resident γδ T cells. Mechanistically, we showed that lung tumor growth is associated with increased bacterial load and altered bacterial composition in the lung. This dysregulated local microbiota stimulated Myd88-dependent IL-1β and IL-23 production from myeloid cells, inducing proliferation and activation of lung-resident Vγ6+Vδ1+ γδ T cells.
Department: Microbiology & Immunology
Contact: Rachel Rivas | 650-497-8716 | rachel.rivas@stanford.edu
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