Ability of Invariant NKT Cells to Modulate the Phenotype and Function of Myeloid Cells
In the last few years it has emerged that invariant NKT (iNKT) cells have the ability to both enhance and inhibit inflammatory responses. However, the mechanisms by which iNKT cells can modulate both pro- and anti- inflammatory responses remain unclear. Multiple mechanisms influencing iNKT-cell activation have emerged, indicating an important link between inflammation and iNKT cells, which results in the modulation of the phenotype of DC, monocytes, neutrophils and B cell activation. We have now extended these results by studying mechanisms which contribute to the anti inflammatory properties of iNKT cells. The significance of these results will be discussed.
Department: Institute for Immunity, Transplantation and Infection
Contact: Michele King | 650 723 3084 | email@example.com
- Dr Vincenzo Cerundolo, MD PhD Professor of Immunology