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M. tuberculosis inhabits macrophages and other professional phagocytes and antigen presenting cells, yet the bacteria are not reliably eliminated by adaptive immune (T cell) responses. In studies in mice, we have discovered that M. tuberculosis inhabits multiple subsets of antigen presenting cells in the lungs, and we have exploited this diversity to discover mechanisms that allow the bacteria to survive and replicate in selected cell subsets, despite the presence of an adaptive immune response. This presentation will discuss the diversity of cells infected by M. tuberculosis in vivo, and will discuss the differences in bacteria-host cell interactions and outcomes, including recent studies of a cell subset that is especially hospitable to M. tuberculosis in vivo and functional pathways tha

Department:  Institute for Immunity, Transplantation and Infection

Contact: Michele King | 650 723 3084 | mking@stanford.edu

Presenter(s):

• Joel ERNST, MD Professor and Chief

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