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Glutamate transporters are responsible for the uptake of the neurotransmitter glutamate from the synaptic cleft into glial cells in a process driven by the energy of ionic gradients. Extensive studies on a bacterial homologue GltPh have shown that these transporters operate by a so-called elevator mechanism, where a distinct “transport” domain moves the substrate and coupled ions across the membrane. The dynamics of this process determine the rate at which the transporters operate. We aim to understand the nature of the energetic barriers that shape the dynamics and function of these transporters and the means of their rational manipulations.

Department:  Neurosciences Institute

Contact: Roula El-Asmar | 6504978031 | roula@stanford.edu

Presenter(s):

• Olga Boudker, PhD Prof. Physiology & Biophysics, Weill Cornell

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