CCSB Seminar: Single-Cell Tumor Transcriptomics: Algorithms and Applications
Jun 28, 2018 (Thu) | 12:00 PM -1:00 PM
Clark Center - S360
: Stanford, CA
Abstract:
Single-cell RNA-seq (scRNA-seq) is increasingly the method of choice for examining the diversity of cell types and functional states within a heterogeneous tumor sample. We previously used scRNA-seq profiling of colorectal tumors, coupled with novel algorithms for data analysis, to uncover novel insights into tumor-specific stromal signatures, epithelial mesenchymal transition (EMT), cancer cell stemness and patient survival. In addition, we discovered distinct cancer-associated fibroblast (CAF) subtypes in colorectal tumors. Subsequent single cell analysis of non-small cell lung tumors revealed an even greater diversity of CAF subtypes.
Department: Radiology
Contact: Ramzi Totah | 6507214161 | rtotah@stanford.edu
Presenter(s):
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