Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Membrane Transporters Beyond Crystal Structures: Dynamics and Thermodynamics of Glutamate Transporters"
Jun 04, 2015 (Thu) | 12:00 PM -1:05 PM
James H. Clark Center, 318 Campus Drive, Seminar Room S360
: Stanford, CA
Lunch to be served at 12:00PM; seminar begins at 12:15PM. Abstract: Glutamate transporters are responsible for clearance of the neurotransmitter glutamate from the synaptic cleft following rounds of neurotransmission. They maintain steep concentration gradients of glutamate by coupling its uptake to symport of sodium ions and protons and to antiport of potassium ions. We have been investigating the molecular mechanism of this family of transporters using an archaeal homologue GltPh as a model system. For GltPh, we not only obtained the crystal structures of key states along the transport cycle, but also probed the dynamics and thermodynamics that define the rates of substrate uptake and the mechanism of coupling the uptake to movements of ions.
Department: BioX
Contact: Christina Huber | 650-725-7472 | chuber@stanford.edu
Presenter(s):
- Olga Boudker Associate Professor of Physiology and Biophysics, Cornell
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