David Morgan, "How the APC drives the cell through mitosis"

May 19, 2014 (Mon) | 4:00 PM -6:00 PM
393 Serra Mall, Herrin T-175 : Stanford, CA

The most dramatic event in cell division is the segregation of the duplicated chromosomes in anaphase of mitosis. This process is triggered by a multi-subunit ubiquitin ligase called the Anaphase-Promoting Complex (APC), which catalyzes the ubiquitination and destruction of proteins that govern anaphase events. We are dissecting the biochemical mechanisms by which the APC is regulated by associated activator subunits, and we are analyzing how these subunits contribute to substrate recognition and ubiquitination. We are also using fluorescence microscopy to identify the mechanisms that determine the precise timing and rates of APC substrate destruction in single yeast cells as they progress through mitosis.

Department:  Biology

Contact: Maria Magana-Lopez | 650-723-2413 | mmagana@stanford.edu

Presenter(s):

  • David Morgan UCSF