Biology Department Special Seminar "Genetic and Functional Proteomic Approaches to Analysing Viral Evasion Pathways

Aug 07, 2013 (Wed) | 12:00 PM -1:15 PM
Clark Center, Room S-362, 318 Campus Drive : Stanford, CA

Our work on viral evasion of the MHC class I antigen presentation pathway has driven an interest in the role of ubiquitin in cell surface immunoreceptor regulation, identified novel ERAD E3 ligases and found a new role for ubiquitin in mRNA degradation. However, a large number of cell surface receptors will be modulated by different intracellular pathogens. This traditional approach of determining whether known ligands (eg MHC I) of critical effector cells (eg CTL) are altered following infection is unable to identify unanticipated cell surface viral targets. We therefore developed an unbiased quantitative proteomics method to identify those receptors whose cell surface expression is altered upon viral infection.

Department:  Biology

Contact: Tammy Learned | 725-4845 |