Sean Wu Lab

Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.

Recent News

September 1, 2015

Congratulations to Arun Sharma whose article titled “Members Only: Hypoxia-induced cell cycle activation in cardiomyocytes” was published in Cell Metabolism

July 15, 2015

Congratulations to Anthony Sturzu, Rajarajan Kuppusamy, Karolina Plonowska, Arun Sharma, Marc Engels, and Adele Xu whose paper titled “Fetal mammalian heart generates a robust compensatory response to cell loss” was published in Circulation and received an editorial comment in the same issue and an investigator highlight on Dr. Sturzu.

July 1, 2015

Dr. Sean Wu has joined the board of Consulting Editors of Circulation Research, the premiere basic cardiovascular research journal. Dr. Wu has been on the Editorial Board since July, 2014 for the Journal and has been an active reviewer for the Journal in the past 10 years.

July 1, 2015

Congratulations to Guang Li who has been award a post-doctoral fellowship from the Child Health Research Institute/Lucile Packard Foundation for Children.