Sean Wu Lab

Lab Overview

My research laboratory seeks to identify mechanisms responsible for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers. We believe that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development we can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role. We currently use both genetically-modified mice as our living model to understand the biology of heart development as well as embryonic stem cells as a test-tube model to study the process of heart cell formation.

Recent News

December 18, 2016

Congratulations to Dr. Sean Wu who has been awarded the Established Investigator Award from the American Heart Association. His application entitled “Transcriptional Mechanism of Cardiac Lineage Development at Single Cell Resolution” received a 2.51 percentile score for funding.

December 15, 2016

Congratulations to high school student intern Thomas Thach who has been accepted to Stanford University’s class of 2021!! We hope he choses to stay here for college and complete an honor thesis project.

December 15, 2016

Congratulations to Mr. Francisco Galdos, and Dr. Sharon Paige whose paper on “Cardiac Regeneration: Lessons from Development” has been accepted for publication at Circulation Research.

December 8, 2016

Congratulations to Mr. Francisco Galdos and Dr. Sharon Paige for being the recipients of the Stanford Society of Physician Scholars research grant. Their project “In Vitro Modeling of Hypoplastic Left Heart Syndrome (HLHS) Using Cardiac Chamber-Specific Reporters in Patient-Derived Induced Pluripotent Stem Cells” will address the underlying molecular mechanism of HLHS using CRISPR-targeted reporter to address cell autonomous vs non-autonomous defects in this disease.

November 6, 2016

Congratulations to Drs. Vahid Serpooshan, Guang Li, and Elda Dzilic whose editorial article on “Mammalian Heart Regeneration: The Race to the Finish Line” has been accepted for publication at Circulation Research.