Muna Aryal Rizal
mentor: Jeremy Dahl and Raag Airan
(2/1/2018 - 1/31/2019)
Muna Aryal earned her MS and PhD in Physics at Boston College in 2014. Her interests focus on developing an ultrasound–based controlled drug design/delivery platform that can positively impact cancer/neurodegenerative patient care. She has been working on an application of early stage medical technology: Focused Ultrasound (FUS) for the treatment of central nervous system diseases in preclinical animal models. She uses this technology to deliver drugs to the brain either by combining with microbubbles to reversibly open the Blood Brain Barrier (BBB) or nanodroplets to locally uncage drug upon sonication. During her Ph.D. thesis and postdoctoral training with Nathan McDannold at Harvard University, she demonstrated that FUS mediated BBB opening allowed sufficient delivery of chemotherapeutics non-invasively to the rat brain tumor to reduce tumor size and increase their survival. During her second postdoctoral fellowship with Dr. Raag Airan at Stanford, she has been using FUS to uncage drug from polymeric-nanodroplets in the brains of rats, and studying the resultant changes in brain function and behavior. However a method is needed to visualize the drug-uncaging event to validate and calibrate the delivered drug dose in a controlled fashion. As a SCIT fellow, she will work with Dr. Jeremy Dahl and Dr. Raag Airan to develop and test the feasibility of passive acoustic imaging (PAI) during FUS drug uncaging from nanodroplets, and determine the spatial and temporal dynamics of the ultrasonic drug uncaging event with respect to its resultant biological effects. Together, this drug delivery phenomenon will be dynamically recorded using the fusion of FUS, PAI, and PET imaging technologies in a large translational animal model. If successful, this effort could yield a closed-loop system for ultrasonic drug delivery, with real time imaging and calibration of the delivered dose that is primed for translation to the clinic immediately.
mentor: Craig Levin
(10/1/2017 - 9/30/2018)
Andrew earned his BS, MS and PhD from the University of Illinois at Urbana-Champaign in Nuclear, Plasma, and Radiological Engineering with a concentration in Radiological and Medical Instrumentation which he formally completed in 2017. Andrew additionally held affiliate status in U of I’s NSF funded neuro-engineering pilot program intended for cross-disciplinary education between engineering and biologically focused students. His research interests focus on developing novel detector technologies and full preclinical/clinical systems with intended application in neuro-oncological and neuro-degenerative studies. Andrew is an experimentalist with direct experience in semiconductor CdTe PET, and X-ray Fluorescence Emission Tomography, and exposure to developing spatially capable EEG through integration with fMRI. As a SCIT fellow, he will work with Prof. Craig Levin to develop a prototype preclinical CZT PET system and work on clinical application of an MR compatible PET insert.
mentors: Brian Hargreaves and Bruce Daniel
(9/1/2017 - 8/31/2018)
Linxi earned her MS in Biomedical Engineering at Worcester Polytechnic Institute in 2010, and PhD in Medical Physics in 2017 from Georgia Institute of Technology. Her research interest is development of quantitative and computational tools to enhance the roles of quantitative imaging in cancer diagnosis and treatment. Her previous research focuses on developing novel artifact correction and reconstruction algorithms for cone beam computer tomography, with concentrations on its application on breast cancer diagnosis and image guided radiation therapy. As a SCIT postdoctoral fellow, she will work with Dr. Brian Hargreaves and use dynamic contrast enhanced MRI with more accurate pharmacokinetic modeling to improve the discrimination of breast cancer.
mentors: Daniel Rubin and Juergen Willmann
(7/1/2017 - 6/30/2018)
Hersh earned his BA in Biochemical Sciences at Harvard in 2007, his MD at Stanford in 2012, and completed a residency in Diagnostic Radiology at the University of Pittsburgh in 2017. He previously worked in the laboratory of Dr. Russ Altman at Stanford, doing research in pharmacogenomics and medical informatics. His current two greatest areas of interest are medical imaging informatics and molecular imaging. He is working in the laboratories of Dr. Daniel Rubin and Dr. Juergen Willmann. As part of an RSNA Fellow grant, he will use machine learning and texture analysis to develop a quantitative tool for the early detection of ovarian cancer. This study will specifically use BR55, a novel molecular imaging agent that targets sites of neoangiogenesis. He is interested in additional opportunities to apply deep learning techniques, as well as correlating radiologic and pathologic data.
mentor: Kim Butts Pauly and Pejman Ghanouni
Pooja earned her BS in Biomedical Engineering at the Johns Hopkins University, and her PhD at Vanderbilt University under the mentorship of Dr. William Grissom. During her doctoral research, she developed MRI methods for measuring temperature changes in the body during focused ultrasound heating treatments. These developments enabled faster measurements by leveraging data undersampling, and more accurate measurements by compensating for MR image distortions that result directly from heating. As a postdoctoral scholar under the guidance of Dr. Kim Butts Pauly, Dr. Gaur will use imaging methods to investigate the intracranial pressure produced by focused ultrasound during tumor ablation and chemotherapy drug delivery treatments for the brain.
Joshua de Bever
mentors: Brian Rutt and Sam Gambhir
Joshua de Bever earned a BS (honors) with a double major in Physics and Computer Science in 2005 and an MS in Physics in 2007 from the University of Western Ontario. While completing his Master’s degree, he designed and fabricated high performance MRI gradient coils. Dr. de Bever earned his PhD from the University of Utah where he performed research in Medical Robotics as part of the MR-guided focused ultrasound group. With this team, Dr. de Bever helped bring a focused ultrasound device for treating breast cancer to clinical trials. His dissertation research included the development of a novel adaptive model-predictive controller for thermal ablation of cancer using focused ultrasound and MR temperature imaging feedback, as well as multiple 3D MR acoustic radiation force imaging techniques. Dr. de Bever will be a postdoctoral scholar in Professor Brian Rutt’s laboratory and is pursuing research into thermal cancer therapies in a high-field MRI environment.
mentors: Sam Gambhir and Robert Sinclair
Hamed Arami received his Dual PhD in December, 2015 in Materials Science and Engineering (MSE) and Nanotechnology and Molecular Engineering (NTME) from the University of Washington. His research interests are development of advanced biomaterials (nanoparticles, hydrogels and scaffolds) for biomedical imaging, targeted therapy, tissue engineering and regenerative medicine. His PhD research was aimed at the development of multifunctional nanoparticle tracers for a new imaging technique called Magnetic Particle Imaging (MPI) and their applications in cancer diagnosis and cardiovascular imaging. Combining MPI with other imaging modalities, such as Magnetic Resonance Imaging (MRI) and Near Infra-Red Fluorescent (NIRF) imaging, he also studied immune response, pharmacokinetics and biodistribution of these nanoparticles and developed chemical approaches to prolong the blood circulation half-life of the MPI tracers in animal models. During his SCIT fellowship, he will work in Prof. Gambhir’s lab to study the role of cancer stem cells on tumors drug resistance and recurrence using intravital microscopy. He also uses iron oxide nanoparticles for targeted differentiation therapy of the cancer stem cells and uses magnetic and fluorescent imaging techniques to track the nanoparticles in animal models.