PUBLICATIONS

Peer Reviewed (42)

• Kas, M.J.H., and D.M. Edgar. A non-photic stimulus inverts the diurnal-nocturnal phase preference in Octodon degus. J. Neuroscience 19: 328-333, 1999.
  

• Klerman, E.B., Z. Boulos, D.M. Edgar, R.E. Mistlberger and M.C. Moore-Ede. Circadian and homeostatic influences on sleep in the squirrel monkey: Sleep after sleep deprivation. Sleep 2: 45-59, 1999.
  

• Olive, F., W.F. Seidel and D.M. Edgar. Compensatory sleep responses to wakefulness induced by the dopamine autoreceptor antagonist (-)DS121. J. Pharmacol. Exp. Ther. 285: 1073-1083, 1998.
  

• O’Hara, B.F., Cao, V.H., Wiler, S.W., Heller, H.C., Edgar, D.M., Kilduff, T.S., and J.D. Miller. Nicotine and nicotine receptors in the SCN. Psychoneuroendocrinology 23: 161-173, 1998.
  

• Bradbury, M.J., W.C. Dement, and D.M. Edgar. Effects of adrenalectomy and subsequent corticosterone treatment on sleep state and EEG power spectra. Am. J. Physiol. 275: R555-R565, 1998.
  

• Edgar, D.M. and W.F. Seidel. Preclinical activity of wake-promoting agents: Clinical relevance of modafinil. Sleep (in press)
  

• Sack, R.L., R.J., Hughes, D.M. Edgar, and A.J. Lewy. Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanism? Sleep 20: 908-915, 1998.
  

• Ruby, N.F., D.M. Edgar, H.C. Heller, and J.D. Miller. The aged suprachiasmatic nucleus is phase shifted by cAMP in vitro. Brain Res. 779: 338-341, 1998.
  

• Kas, M.J.H., W.F. Seidel, B. and D.M. Edgar. Circadian rhythms of sleep and wake in the Octodon degus. J. Biol. Rhythms 13: 9-17, 1998.
  

• Bradbury, M.J., W.C. Dement and D,M. Edgar. 5HT-containing fibers in the hypothalamus attenuate light-induced phase delays in mice. Brain Res. 768: 125-134, 1997.
  

• Edgar, D.M., and W.F. Seidel. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J. Pharmacol. Exp. Ther 283: 757-769, 1997.
  

• Edgar, D.M., W.F. Seidel, K.W. Gee, N.C. Lan, G. Field, H. Xia, J.E. Hawkinson, S. Wieland, R.B. Carter and P.L. Wood. CCD-3693: An orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. J. Pharmacol. Exp. Ther 282: 420-429, 1997.
  

• Edgar, D.M., M.S. Reid, and W.C. Dement. Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock. Am. J. Physiol. 42: R265-R269, 1997.
  

• Seidel, W.F., M. Maze, W.C. Dement and D.M. Edgar. Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. J. Pharmacol. Exp. Ther. 275: 263-273, 1995.
  

• Glotzbach, S.F., D.M. Edgar, and. R.L. Ariagno. Biological rhythmicity in preterm infants prior to discharge from neonatal intensive care. Pediatrics 95: 231-237, 1995.
  

• Edgar, D.M. In search of neurobiological mechanisms regulating sleep-wakefulness: An empirical and historical account of two opponent processes. Sleep Res. Soc. Bull. 1(2): 22-27, 1995.
  

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• Edgar, D.M. Control of sleep-wake cycles by the mammalian suprachiasmatic pacemaker. Sleep Res. Soc. Bull. 1(1): 2-7, 1995.
  

• Glotzbach, S.F., D.M. Edgar, M. Boeddiker and R.L. Ariagno. Biological rhythmicity in normal infants during the first 3 months of life. Pediatrics 94: 482-488, 1994.
  

• Prosser, R.A., D.M. Edgar, H.C. Heller, J.D. Miller. A possible glial role in the mammalian circadian clock. Brain Res. 643: 296-301, 1994.
  

• Edgar, D.M. Sleep-wake circadian rhythms and aging: Potential etiologies and relevance to age-related changes in integrated physiological systems. Neurobiol. Aging 15(4): 499-501, 1994.
  

• Dantz, B., D.M. Edgar and W.C. Dement. Circadian rhythms in narcolepsy: Studies on a 90-minute day. Electroencephal. Clin. Neurophysiol. 90: 24-35, 1994.
  

• Prosser, R.A., D.M. Edgar, R.R. Dean, H.C. Heller, and J.D. Miller. Serotonin and the mammalian circadian system. I. In vitro phase-shifting by serotonergic agonists and antagonists. J. Biol. Rhythms. 8: 1-16, 1993.
  

• Mignot, E., S. Nishino, L. Hunt-Sharp, J. Arrigoni, J.M. Siegel, M.S. Reid, D.M. Edgar, R.D. Ciaranello and W.C. Dement. Heterozygocity at the CANARC-1 locus can confer susceptibility for narcolepsy: Induction of cateplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J. Neuroscience 13: 1057-1064, 1993.
  

• Glotzbach, S.F., E.A. Rowlett, D.M. Edgar, R.J. Moffat and R.L. Ariagno. Light in the modern NICU: Chronobiologic issues. Medical Hypotheses 41:217-224, 1993.
  

• Edgar, D.M., J.D. Miller, R.A. Prosser, R.R. Dean, and W.C. Dement. Serotonin and the mammalian circadian system. II. Phase-shifting behavioral rhythms with serotonergic agonists. J. Biol. Rhythms. 8: 17-31, 1993.
  

• Edgar, D.M., W.C. Dement and C. A. Fuller. Effect of SCN-lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J. Neuroscience 13: 1065-1079, 1993.
  

• Mignot, E., D.M. Edgar, J.D. Miller, R.A. Prosser, R.N. Van Gelder, S. Nishino, W.C. Dement. Strategies for the development of new treatments in sleep disorders. Int Acad Biomed Drug Res 3(11): 129-150, 1992.
  

• Trachsel, L., D.M. Edgar, W.F. Seidel, H.C. Heller, and W.C. Dement. Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: effects of sleep deprivation and triazolam administration. Brain Res., 589: 253-261, 1992.
  

• Van Gelder, R.N., D.M. Edgar and W.C. Dement. Real-time automated sleep scoring: validation of a microcomputer-based system for mice. Sleep 14: 48-54, 1991.
  

• Trachsel, L., D.M. Edgar and H.C. Heller. Are ground squirrels sleep deprived during hibernation? Am. J. Physiol. 260: R1123-1129, 1991.
  

• Krilowicz, B.L., D.M. Edgar and H.C. Heller. Reticular formation activity during wakefulness and sleep in a hibernator (Spermophilus lateralis). Brain Res. 540: 266-272, 1991.
  

• Edgar, D.M., W.F. Seidel, C.E. Martin, P.P. Sayeski and W.C. Dement. Triazolam fails to induce sleep in SCN-lesioned rats. Neurosci. Letters. 125: 125-128, 1991.
  

• Edgar, D.M., W.F. Seidel and W.C. Dement. Triazolam-induced sleep in the rat: influence of prior sleep, circadian time, and light/dark cycles. Psychopharmacology 105: 374-380, 1991.
  

• Edgar, D.M., C.E. Martin and W.C. Dement. Activity feedback to the mammalian circadian pacemaker: influence on observed measures of rhythm period length. J. Biol. Rhythms 6: 185-199, 1991.
  

• Edgar, D.M., T.S. Kilduff, C.E. Martin and W.C. Dement. Influence of wheel activity on free-running sleep-wake and drinking circadian rhythms in mice. Physiol. Behav. 50: 373-378, 1991.
  

• Edgar, D.M. and W.C. Dement. Regularly scheduled voluntary exercise synchronizes the mouse circadian clock. Am. J. Physiol. 26: R928-R933, 1991.
  

• Trachsel, L., D.M. Edgar, C. Haberland and H.C. Heller. Arousal from hibernation in order to sleep? In: Sleep '90, J. Horne (Ed.), Pontenagel Press, Bochum, 1990, pp 363-366.
  

• Bliwise, D.L., W.C. Bevier, N.G. Bliwise, D.M. Edgar and W.C. Dement. Systematic 24-Hour obervations of sleep/wakefulness in a skilled care nursing facility. Psychology and Aging, 5: 16-24, 1990.
  

• Krilowicz, B.L., D.M. Edgar, and H.C. Heller. Action potential duration increases as body temperature decreases during hibernation. Brain Research 498: 73-80, 1989.
  

• Edgar, D.M., R.N. VanGelder and C. Guilleminault. Invited commentary. Sleep 11(2): 220-221, 1988.
  

• Fuller, C.A. and D.M. Edgar. Effects of light intensity on the circadian temperature and feeding rhythms in the squirrel monkey. Physiol. Behav. 36: 687-691, 1986.
  

• Edgar, D.M. and C.A. Fuller. Primate body temperature and sleep responses to lower body positive pressure. Physiologist 27: S95-S96, 1984.
  

• Bradbury, M.J., W.C. Dement, and D.M. Edgar. Decreased voluntary exercise does not reflect aging of the circadian pacemaker: A longitudinal study in Wistar rats. Neurobiol. Aging (in revision)
  

• Bradbury, M.J., M.J.H. Kas, and D.M. Edgar. Entrainment and masking in young and old mice: Effects of light intensity. Am. J. Physiol.
  

• Kas, M.J.H., and D.M. Edgar. Photic phase response curve in Octodon degus: assessment as a function of activity phase preference. Am. J. Physiol.
  

• Kas, M.J.H., and D.M. Edgar. Scheduled voluntary wheel running activity modulates free-running circadian body temperature rhythms in Octodon degus. J. Biol. Rhythms
  

• Kas, M.J.H., and D.M. Edgar. Wheel running inverts light-dark cycle masking of sleep-wakefulness and behavioral activity in Octodon degus. Am. J. Physiol.
  

• Kas, M.J.H., and D.M. Edgar. Crepuscular timed wakefulness opposes sleep homeostasis after sleep deprivation in Octadon degus. Sleep
  

• Klerman, E.B., Z. Boulos, D.M. Edgar, R.E. Mistlberger and M.C. Moore-Ede. EEG delta activity during undisturbed sleep in the squirrel monkey. Sleep (in revision)
  

• Seidel, W.F., W.C. Dement, and D.M. Edgar. Circadian variation in the effects of nefazodone, fluoxetine and ritanserine on sleep, locomotor activity and body temperature in rats. Neuropsychopharm (in revision)
  

• Wurts, S.W., and D.M. Edgar. Caffeine during sleep deprivation: Sleep tendency and dynamics of recovery sleep in rats. Pharmacol. Biochem. Behav.

Non-Peer Reviewed Periodicals and Commentary (3)

• Edgar, D.M. The NEW SRS training and education program: Fostering the career development of SRS trainees. SRS Bulletin 2(2): 21-23, 1998.

• Edgar, D.M. Sleep and wakefulness in biological time. Sleep Medicine Alert 3(2):1-2 & 4, 1998.
  

• Edgar, D.M. Tinkering with the circadian clock. Stanford Medicine 15 (1): 17 & 32, 1997.
  

Book Chapters (9)

• Dijk, D-J. and D.M. Edgar. The circadian and homeostatic control of wakefulness and sleep. In: F.W. Turek and P.C. Zee (Eds.) Neurobiology of Sleep and Circadian Rhythms (series: Lung Biology in Health and Disease). New York: Marcel-Decker, Inc., in press (1998).

• Tedford, C.E. and D.M. Edgar. Histaminergic regulation of sleep-wakefulness. In: The Neurobiology of Histamine, G.D. Prell, ed, Humana Press: Totowa, NJ, 1998 (in press)
  

• Edgar, D.M. Control of sleep/wakefulness: Implications in shift work and therapeutic strategies. In: Physiological Basis of Occupational Health: Stressful Environments. Shiraki, K., Sagawa, S., and Yousef, M.K., eds. , Amsterdam: SPB Academic Publishing. Serial: Progress in Biometry 11: 253-265, 1996.
  

• Heller, H.C., D.M. Edgar, D.A., Grahn, and S.F. Glotzbzch. Sleep, thermoregulation, and circadian rhythms. In: Handbook of Physiology Section 4, Environmental Physiology Vol II. American Physiological Society, Fregly, M.J. and Blatteis, C.M., eds., Oxford University Press: New York, pp. 1361-1374, 1996.
  

• Ariagno, R.L., D.M. Edgar, and S.F. Glotzbach. Chronobiological issues in the neonatal intensive care nursery. In: Creating Hospital Environments for Newborn Special Care, Esther Silverman (ed.) , pp. 72-76, 1993.
  

• Edgar, D.M. Functional role of the suprachiasmatic nuclei in the regulation of sleep and wakefulness. In: Fatal Familial Insomnia: Inherited Prion Diseases, Sleep, and the Thalamus (Guilleminault, C., E. Lugaresi, P. Montagna, P. Gambetti, eds.) Raven Press: New York, 1993, pp. 203-213.
  

• Edgar, D.M., W.C. Dement and C. Guilleminault. Circadian and homeostatic determinants of sleep and aging. In: Sleep and Respiration in Aging Adults, Kuna, S.T., P.M. Suratt, J.E. Remmers (Eds.), Elsevier, New York, 1991, pp 57-60.
  

• Guilleminault, Ch., D. Edgar and R. Stoohs. Sleep and circadian rhythms. In: Etat de Veille et de Sommeil. Actualites de Pharmacologie Clinique, Vol. 7, P. Meyer, J. Elghozi and A. Salva, (Eds.), Masson, Paris, 1989, pp 1-12.
  

• Edgar, D.M., W.C. Dement and C. Guilleminault. Sleep, exercise and age related changes in circadian timekeeping. In: Proceedings, Fourth Congress of the International Psycogeriatric Association, A. Homma (Ed.), Tokyo, Japan, Sept 5-8, 1989.
  

Government Publications (1)

• Holley, D.C., C.M. Winget, C.W. DeRoshia, M.P. Heinold, D.M. Edgar, N.E. Kinney, S.E. Langston, C.L. Markley, and J.A. Anthony. Effects of Circadian Rhythm Phase Alteration on Physiological and Psychological Variables: Implications to Pilot Performance. Ames Research Center, Moffett Field, CA; NASA Technical Memorandum 81277, March 1981, 538 pp.

Representative Manuscripts Currently in Preparation

• Edgar, D.M., W.F. Seidel and W.C. Dement. Compensatory responses to sleep deprivation are impaired in aged rats. Am. J. Physiol.
  

• Edgar, D.M., M. Kas, W.F. Seidel, W.C. Dement, and M.R. Ralph. Sleep architecture in the period mutant hamster: Interaction between light and the circadian clock. Am. J. Physiol.
  

• Edgar, D.M., W.F. Seidel, W.C. Dement and E. Mignot. Wakefulness pharmacologically uncoupled from sleep homeostasis. Science
  

• Edgar, D.M., W.F. Seidel and W.C. Dement. Alertness and recovery sleep after caffeine and methamphetamine treatment in rats. Neuropsychopharmacology
  

• Edgar, D.M., M.R. Ralph, W.F. Seidel, L.K. Lee, and W.C. Dement. Fetal suprachiasmatic transplants restore sleep-wake and body temperature circadian rhythms in the rat. Brain Research
  
• Edgar, D.M., C.E. Martin, and W.C. Dement. Competition between photic and exercise-dependent zeitgebers in the mouse (Mus musculus). J. Biol. Rhythms
  
• Edgar, D.M., C.E. Martin, and W.C. Dement. Activity-dependent feedback to the mouse circadian clock: Measures of exercise duration and intensity sufficient for entrainment. J. Biol. Rhythms.
  
• Edgar, D.M., C.A. Fuller. Light-dark cycle masking of sleep-wakefulness and brain temperature in the squirrel monkey (Saimiri sciureus). Am. J. Physiol.