The SCN lab is an integrated, multidisciplinary research facility dedicated to;
- understanding sleep-wake control and biological rhythms at all levels from the molecular to the behavioral, and
- developing new generations of pharmaceuticals to remedy the enormous unmet needs of sleep disorders medicine and disorders of circadian timekeeping.
SPECIAL RESOURCE AND MODEL SYSTEM FOR RESEARCH AND DRUG TESTING IN THE SCN LAB
- A large scale sleep-wake and circadian rhythm bioassay facility
- Automated data tracking and analysis computers to assure rapid, accurate communication of experimental results to research sponsors
- Unique animal model systems include a narcoleptic rodent colony for testing alerting pharmacological agents and other genetically engineered mouse models.
- Pharmacology in sleep deprived animals
- MPEG video monitoring system synchronized with EEG signals
- In vivo microdialysis and HPLC analysis for neurotransmitter and regional drug delivery studies together with sleep monitoring
- Neurochemical assessments, such as radio receptor bindings/gamma GTP- binding and radio/enzyme-immuno assays and analysis of gene expressions (quantitative RT-PCR)
- Molecular biology laboratory
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