Selected Publications

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  • Mignot E, Taheri S, Nishino S. Sleeping with the Hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci. 2002 Nov;5 Suppl:1071-5. Article (),

  • Mignot E, Lammers GJ, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Bassetti C, Shrader H, Nishino S. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol. 2002 Oct;59(10):1553-62. Article ()

  • Mignot E. History of narcolepsy : a hundred years of research. Arch. Ital. Biol. 2001 Apr;139(3):207-20. Review. Article ()

  • Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu S, Leffell M, Grumet F, Fernandez-Vina M, Honda M, Risch N. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001 Mar;68(3):686-99. American Journal of Human Genetics, March 1st, 2001. Article ()

  • Hungs M, Mignot E. Hypocretin/orexin, sleep and narcolepsy. Bioessays. 2001 May;23(5):397-408. Article ()

  • Hungs M, Fan J, Lin L, Lin X, Maki RA, Mignot E. Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines. Genome Res. 2001 Apr;11(4):531-9. Article ()

  • Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001 Mar 1;21(5):1787-94. Article ()

  • Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep;6(9):991-7. Article ()

  • Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E.Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000 Jan 1;355(9197):39-40. Article ()

  • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999 Aug 6;98(3):365-76. Article ()

  • Anic-Labat S, Guilleminault C, Kraemer HC, Meehan J, Arrigoni J, Mignot E. Validation of a cataplexy questionnaire in 983 sleep-disorders patients. Sleep. 1999 Feb 1;22(1):77-87. Article ()

  • Mignot E. Genetic and familial aspects of narcolepsy. Neurology, 50(Suppl.1): 516-522, 1998.

  • Mignot E., Young T., Lin L., Finn L., Palta M. Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults. The Lancet 531: 727, 1998. Article ()

  • Nishino S., Mignot E. Pharmacological aspects of human and canine narcolepsy. Prog. Neurobiol. 52: 27-78, 1997. Article ()

  • Ellis M, Hetisimer AH, Ruddy DA, Hansen SL, Kronmal GS, McClelland E, Quintana L, Drayna DT, Aldrich MS, Mignot E. HLA Class II haplotype and sequence analysis support a role for DQ in narcolepsy. Immunogenetics, 46:410-417, 1997. Article ()

  • Mignot E, Kimura A, Lattermann A, Lin X, Yasunaga S, Mueller-Eckhardt G, Rattazzi C, Lin L, Guilleminault C, Grumet FC, Mayer G, Dement WC, Underhill P. Extensive HLA Class II studies in 58 non DRB1*15 (DR2) narcoleptic patients with cataplexy. Tissue Antigens, 49: 329-341, 1997.

  • Mignot E, Tafti M, Dement WC, Grumet FC. Narcolepsy and Immunity. Adv. Neuroimmunology 5 (1): 23-37, 1995.

  • Mignot E., Nishino S., Hunt-Sharp L., Arrigoni J., Siegel J.M., Reid M.S., Edgar D.M., Ciaranello R.D., Dement W.C. Heterozygocity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J. Neurosci, 13(3): 1057-1064, 1993.

  • Matsuki K., Grumet F.C., Lin X., Guilleminault C., Dement W.C., Mignot E. DQ rather than DR gene marks susceptibility to narcolepsy. The Lancet 339: 1052, 1992.

  • Mignot E., Wang C., Rattazzi C., Gaiser C., Lovett M., Guilleminault C., Dement W.C., Grumet F.C. Genetic linkage of autosomal recessive narcolepsy with an immunoglobulin µ chain switch-like segment. Proc. Natl. Acad. Sci. (USA), 88: 3475-3478, 1991.

  • Guilleminault C., Mignot E., Grumet C. Familial patterns of narcolepsy. The Lancet 333: 1376-1379, 1989.