Selected Publications

  • Corder G, Castro D, Bruchas MR, Scherrer G. Endogenous and Exogenous Opioids in Pain. Annu Rev Neurosci. 2018. In press.
  • Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G. Functional divergence of delta and mu opioid receptor organization in CNS pain circuits. Neuron. 2018 Apr 4;98(1):90-108.e5. doi: 10.1016/j.neuron.2018.03.002. Epub 2018 Mar 22. PMID: 29576387.
  • François A, Low SA, Sypek E, Christensen AJ, Sotoudeh C, Beier KT, Ramakrishnan C, Sharif-Naeini R, Deisseroth K, Scott L Delp, Malenka R, Luo L, Hantman A, Scherrer G. A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins. Neuron. 2017 Feb 22;93(4):822-839. PMID: 28162807.
  • Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR, Sotoudeh C, Clark DJ, Barres BA, Bohlen C, Scherrer G. Loss of mu opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesia. Nat Med. 2017 Feb;23(2):164-173. PMID: 28092666.
  • Christensen AJ, Iyer SM, François A, Vyas S, Ramakrishnan C, Vesuna S, Deisseroth K, Scherrer G, Delp SL. In vivo interrogation of spinal mechanosensory circuits. Cell Reports. 2016 Nov 1;17(6):1699-1710. PMID: 27806306.
  • Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Aug 17:1-6. PMID: 27533032.
  • Dickinson JR and Scherrer G. Enhanced dendritic integration by Ih reduction in the anterior cingulate cortex increases nociception. Neuron. 2015 Apr 8;86(1):4-6. PMID: 25856476.
  • Wu YW, Kim JI, Tawfik VL, Lalchandani RR, Scherrer G, and Ding JB.Differential Expression of CB1 Receptor-Dependent LTD at Corticostriatal and Thalamostriatal Synapses. Cell Reports. 2015 Jan 6;10(1):75-87. PMID: 25543142
  • Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith C, de Nooij JC, Mennicken F, O’Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 2014 Mar 19;81(6):1312-27. PMCID: PMC4072501
  • Gaillard S, Lo Re L, Mantilleri A, Hepp R, Urien L, Malapert P, Alonso S, Deage M, Kambrun C, Landry M, Low SA, Alloui A, Lambolez B, Scherrer G, Le Feuvre Y, Bourinet E, Moqrich A. GINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia. Neuron. 2014 Sep 17. PMID: 25242222
  • Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22296-301. PMCID: PMC3009833
  • Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O’Donnell D, Kieffer BL, Basbaum AI. Dissociation of opioid receptor mechanisms that control mechanical and heat pain. Cell. 2009 Jun 12;137(6):1148-59. PMCID: PMC3683597
  • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and Molecular Mechanisms of Pain. Cell. 2009 Oct 16;139(2):267-84. PMCID: PMC2852643
  • Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. Knock-in mice expressing fluorescent delta opioid receptors uncover G protein receptor dynamics in vivo. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9691-6. PMCID: PMC1480468