Daniel V. Madison
Title
Associate Professor
Department
Molecular and Cellular Physiology
Research Interests
Synaptic plasticity and neurochemical modulation of neuronal excitability
in the CNS.
Email
madison@stanford.edu
Phone
725-7563
Fax
725-4628
Address
Beckman Center B003
Mail Code: 5345
Faculty Research Description
Our laboratory uses electrophysiological techniques to study the mechanisms
of synaptic transmission and plasticity in the mammalian hippocampus.
The main focus of the lab is the study of long term potentiation (LTP)
and long-term depression (LTD), th emost widely studeid and compelling
models for the mechanisms underlying memory formation in the mammalian
central nervous system. We study these plastic processes primarily in
the very small populations of synapses formed between individual pairs
of hippocampal neurons. These small population measures, combined with
the introduction of mutant genes into the pre and/or postsynaptic member
of a cell pair provide a powerful methodology for dissecting the mechanisms
of these plastic processes. Studies in the lab are carried out using a
full range of electrophysiological techniques including extracellular
field potential recording, intracellular recording,whjole cell and single
channel recording in hippocampal slices and cultured neurons.
McQuiston, A.R. and Madison, D.V. (1999). Nicotinic Receptor Activation Excites Distinct Subtypes of Interneurons in the Rat Hippocampus.Ê Journal of Neuroscience 19, 2887-2896.
Usdin, M., Shelbourne, P., Myers, R.M. and Madison D.V. (1999). Impaired Synaptic Placticity in Mice Carrying the Huntington's Disease Mutation. Human Molecular Genetics 8, 839-846.
McQuiston, A.R. and Madison, D.V. (1999). Muscarinic Receptor Activity has Multiple Effects on the Resting Membrane Potentials of CA1 Hippocampal Interneurons. Journal of Neuroscience 19, 5693-5702.
McQuiston, A.R. and Madison, D.V. (1999). Muscarinic Receptor Activity Induces and Afterdepolarization in a Subpopulation of Hippocampal CA1 interneurons.Ê Journal of Neuroscience 19, 5703-5710.
Pavlidis, P. and Madison, D.V. (1999). Synaptic Transmission in Pair Recordings From CA3 Pyramidal Cells in Organotypic Culture.Ê Journal of Neurophysiology 81, 2787-2797.
Pavlidis, P., Mongomery, J. and Madison, D.V. (2000). Presynaptic Protein Kinase Activity Supports Long-Term Potentiation at Synapses Between Individual Hippocampal Neurons. Journal of Neuroscience 20, 4497-4505.
Braun, J.E.A. and Madison, D.V. (2000). A Novel SNAP25-Caveolin Complex Correlates with the Onset of Persistent Synaptic Potentiation.Ê Journal of Neuroscience 20, 5997-6006.
Montgomery, J.M., Pavlidis, P, and Madison, D.V. (2001). All-Silent Synaptic Connections Reveal the Postsynaptic Expression of Long-Term Potentiation.Ê Neuron 29, 691-701.
Areas of Study
Systems/Behavioral Neuroscience
Cellular Neurobiology
Membrane Excitability
SBRC
Ph.D.