Griffith Harsh






		Griffith Harsh Title Professor Department Neurosurgery Research Interests Molecular mechanisms of brain tumor development. Gene therapy of brain tumors. Clinical managment of brain tumors. Email gharsh@stanford.edu Phone 723-6093 Fax 723-7813 Address Edwards 227 Mail Code: 5327 Faculty Research Description Molecular mechanisms of brain tumor development Servidi T et al: The protein-tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons, and renition astrocytes. Neuroscience 82:529-543, 1998 Boucher Y et al: Interstitial fluid pressure in intracranial tumors in patients and rodents. Br J Cancer 75:829-836, 1997 Reeves S et al: An alternative role for the src-homology-domain-containing phosphotyrosine phosphatase (SH-PTP2) in regulating epidermal-growth-factor-dependent cell growth. European Journal of Biochemistry 1995; 233:55-61 Alderson L et al: Human gliomas with wild-type p53 express bcl-2. Cancer Research 1995; 55:999-1001. Yong WH et al: Chromosome 19q deletions in human gliomas overlap telomeric to D19S219 and may target a 425 kb region centrometric to D19S112. Journal of Neuropathology and Experimental Neurology 1995; 622-626. Raffel C et al: The multiple tumor suppressor 1/cyclin dependent kinase inhibitor 2 gene (MTS1/CDKN2) in human central nervous system primitive neuroectodermal tumor. Neurosurgery 1995; 36:971-975. Lyons J et al: Two G protein oncogenes in human endocrine tumors. Science 1990; 249:655- 659. Gene therapy of brain tumors Harsh G et al: Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: A gene marking and neuropathologic study. J Neurosurg 92:804-811, 2000 Qureshi N et al: Multicolumn infusion of gene therapy cells into human brain tumors: Technical report. Neurosurgery 46:663-669, 2000 Ikeda K et al: Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nature Medicine 5(8):881-7, 1999 Barnett F et al: Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer Gene Therapy. 6(1):14-20, 1999 Ono Y et al: Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Human Gene Therapy 8: 2043-2055, 1997 Rainov NG et al: Retrovirus-mediated gene therapy of experimental brain neoplasms using the Herpes simplex virus/ganciclovir paradigm. Cancer Gene Therapy 3:99-106, 1996 Clinical management of brain tumors Peterson K et al: Daily low dose carboplatin as a radiation sensitizer for newly discovered malignant glioma; J Neuro-Onc, In Press, 2001 Harsh G et al: Pedicled rhinotomy for clival chordomas invaginating the brainstem. J Neurosurg (Neurosurg Focus), In Press, 2001 Fitzek M et al: Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial. Journal of Neurosurgery 91:251-260, 1999 Enochs W et al: Improved delineation of human brain tumors on MR images using a long- circulating, superparamagnetic iron oxide agent. Journal of Magnetic Resonance Imaging. 9(2):228-32, 1999 Bruening R et al: Echo-planar MR determination of relative cerebral blood volume in human brain tumors: T1 versus T2 weighting. AJNR An J Neuroradiol 17:831-840, 1996 Megerian CA et al The subtemporal-transpetrous approach for excision of petroclival tumors. Am J Otol 17: 773-779, 1996 Harsh G et al: Anterior midline approaches to the central skull base. Clinical Neurosurgery 43:15-43, 1996 Kim L et al: Procarbazine, comustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas. J Neurosurg 1996; 85:602-607 Flickinger JC et al: A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys 1994; 28:1039-1047. Int J Radiat Oncol Biol Phys 1995;31:693. Int J Radiat Oncol Biol Phys 1995; 32:557-559 Pardo FS et al: Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant gliomas. Int J Radiat Oncol Biol Phys 1994; 30:663- 669 Duma C et al: Stereotactic radiosurgery of cavernous sinus meningiomas as an addition or alternative to microsurgery. Neurosurgery 1993; 32:699-705. Areas of Study SBRC