Karl Deisseroth

Research Interests
Neural stem cells, neuroengineering, adaptive plasticity, electrophysiology, two-photon imaging, animal behavior, computational modeling, neuropsychiatry, developing noninvasive technologies for focal brain stimulation.

Email
mailto:deissero@stanford.edu

Phone
736-4325

Fax
725-7799

Address
Clark Center W083
Mail Code: 5444

http://biox.stanford.edu/clark/deisseroth.html

Research in Dr. Deisseroth's laboratory focuses on developing molecular and cellular tools to observe, perturb, and re-engineer brain circuits. His laboratory is based in the James H. Clark Center at Stanford and employs a range of techniques including neural stem cell and tissue engineering methods, electrophysiology, molecular biology, neural activity imaging, animal behavior, and computational neural network modeling. Also a clinician in the psychiatry department, Professor Deisseroth employs novel electromagnetic brain stimulation techniques in human patients for therapeutic purposes.

Deisseroth K., Bito H., and Tsien R.W. (1996). Signalling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16, 89-101.

Bito H., Deisseroth K., and Tsien R.W. (1996). CREB phosphorylation and dephosphorylation: a Ca2+- and stimulus duration- dependent switch for hippocampal gene expression. Cell 87, 1203-1214.

Deisseroth K., Heist E.K., and Tsien R.W. (1998). Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature 392, 198-202.

Zhlke R., Pitt G.S., Deisseroth K., Tsien R.W., and Reuter H. (1999). Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 399, 159-162.

Graef I.A., Mermelstein P.G., Stankunas K., Neilson J.R., Deisseroth K., Tsien R.W., and Crabtree, G. (1999). Interplay of L-type calcium channels and GSK-3 in regulating the localization and activity of NF-ATc4 in hippocampal neurons. Nature 401, 703-708.

Wu G.-Y., Deisseroth K., and Tsien R.W. (2001). Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nature Neuroscience 4, 151-158.

Deisseroth K. and Tsien R.W. (2002). Dynamic multiphosphorylation passwords for activity-dependent gene expression. Neuron 34, 179-182.

Deisseroth K., Mermelstein P.G., Xia H. and Tsien R.W. (2003). Signaling from synapse to nucleus: the logic behind the mechanisms. Current Opinion in Neurobiology 13:3, 354-365.

Deisseroth K., Singla S., Toda H., Monje M., Palmer T.D., and Malenka R.C. (2004). Excitation-neurogenesis coupling in adult neural stem-progenitor cells. Neuron 42, 535-552.

Areas of Study
Systems/Behavioral Neuroscience
Cellular Neurobiology
Membrane Excitability
Molecular Neurobiology
PhD