Alzheimer's Disease Models
Alzheimer’s disease (AD), the most common cause of dementia, is an age dependent progressive neuro-degenerative disorder. Amyloid-beta (a metabolic product of amyloid precursor protein; APP) plays an important role in pathology of AD.
PS19 Transgenic (Tg) mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age. Thus, the strain is commonly used as a model of tauopathy, such as Alzheimer's Disease.