The Activity Chamber is a simple assessment test used to determine general activity levels, gross locomotion activity, and exploration habits in rodent models of CNS disorders. Assessment takes place in a square arena mounted with three planes of infrared detectors within a specially designed sound attenuating chamber. The animal is placed in the center of the testing arena and allowed to freely move while being tracked by an automated tracking system. Distance moved, velocity, jump count, vertical count, time immobile, and times spent in pre-defined areas of the arena are recorded. The Activity Chamber is useful for phenotyping transgenic strains of mice and evaluating novel chemical entities for their effect on overall activity.