Selected publications:

JS Lim, A Ibaseta, MM Fischer, B Cancilla, G O’Young, S Cristea, VC Luca, D Yang, NS Jahchan, C Hamard, M Antoine, M Wislez, C Kong, J Cain, YW Liu, AM Kapoun, KC Garcia, T Hoey, CL Murriel, J Sage. Intratumoral heterogeneity generated by Notch signaling promotes small-cell lung cancer. Nature, 2017 May 10.


NS Jahchan, JS Lim, B Bola, K Morris, G Seitz, KQ Tran, L Xu, F Trapani, CJ Morrow, S Cristea, GL Coles, D Yang, D Vaka, MS Kareta, J George, PK Mazur, T Nguyen, WC Anderson, SJ Dylla, F Blackhall, M Peifer, C Dive, J Sage. Identification and targeting of long-term tumor-propagating cells in small cell lung cancer. Cell Reports,
2016 June 30.


SK Denny*, D Yang*, CH Chuang, JJ Brady, JS Lim, BM Grüner, SH Chiou, AN Schep, J Baral, C Hamard, M Antoine, M Wislez, CS Kong, AJ Connolly, KS Park, J Sage**, WJ Greenleaf**, MM Winslow**. Nfib promotes metastasis through a widespread increase in chromatin accessibility. *, equal contribution. **, co-senior authors. Cell, 2016 June 30.


K Weiskopf*, NS Jahchan, PJ Schnorr, S Cristea, A Ring, RL Maute, AK Volkmer, JP Volkmer, J Liu, JS Lim, D Yang, G Seitz, T Nguyen, D Wu, K Jude, H Guerston, A Barkal, F Trapani, J George, JT Poirier, EE Gardner, LA Miles, E de Stanchina, SM Lofgren, H Vogel, MM Winslow, C Dive, RK Thomas, CM Rudin, M van de Rijn, R Majeti, KC Garcia, IL Weissman*, J Sage*. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. *, co-corresponding authors. Journal of Clinical Investigation, 2016 June 13.


N Reynoird*, PK Mazur*, T Stellfeld, NM Flores, SM Lofgren, SM Carlson, E Brambilla, P Hainaut, EB Kaznowska, CH Arrowsmith, P Khatri, C Stresemann, O Gozani**, J Sage**. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes Dev, 2016 Apr 1;30(7):772-85. doi: 10.1101/gad.275529.115. Epub 2016 Mar 17. *, equal contribution. **, equal contribution and co-corresponding authors.


PK Mazur* **, A Herner*, SS Mello, M Wirth, S Hausmann, T Kuschma, FJ Sanchez-Rivera, S Lofgren, SA  Hahn, D Vangala, M Trajkovic-Arsic, A Gupta, R Braren, M Erkan, J Kleeff, B Sipos, M Heikenwälder, E Heßmann, V Ellenrieder, I Esposito, T Jacks, JE Bradner, P Khatri, LD Attardi, RM Schmid, G Schneider, J Sage**, JT Siveke**. Synergistic suppression of pancreatic cancer by combined inhibition of the BRD4 and HDAC chromatin regulators. Nature Medicine, 2015, Sept 21.*, co-first authors, **, co-corresponding authors.


J George*, JS Lim*, …,  M Peifer**, J Sage **, RK Thomas **. Comprehensive genomic characterization of small cell lung cancer. Nature, 2015; online July 15. *, co-first authors, **, co-corresponding authors.    


MS  Kareta, LL Gorges, S Hafeez, BA Benayoun, S Marro, AF Zmoos, MJ Cecchini, D Spacek, LFZ Batista, M O’Brien, YH Ng, CE Ang, D Vaka, SE Artandi, FA Dick, A Brunet, J Sage*, M Wernig*. Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis. Cell Stem Cell, 2015, Jan; 16:39-50.*, co-corresponding authors.

L Xu, FK Hazard, AF Zmoos, N Jahchan, H Chaib, PM Garfin, A Rangaswami, M Snyder, J Sage. Genomics analysis of fibrolamellar hepatocellular carcinoma. Hum Mol Genet, 2014, published online August 13.

U Ehmer, AF Zmoos, RK Auerbach, D Vaka, AJ Butte, MA Kay, J Sage. Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo. Cell Reports, 2014, published online July 10.

PK Mazur*, N Reynoird*, P Khatri, PW Jansen, AW Wilkinson, S Liu, O Barbash, GS Van Aller, M Huddleston, D Dhanak, PJ Tummingo, RG Kruger, AJ Butte, Vermeulen, J Sage**, O Gozani**. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature, 2014. *, equal contribution.**, equal contribution and co-corresponding authors.

N Jahchan, JT Dudley, PK Mazur, N Flores, D Yang, A Palmerton, AF Zmoos, D Vaka, KQ Tran, M Zhou, K Krasinska, JW Riess, JW Neal, KS Park, P Khatri, AJ Butte*, J Sage*. A drug repositioning approach identifies tricyclic antidepressants as potent inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discovery, 2013. *, co-corresponding authors.

P. Garfin, D Min, J Bryson, T Serwold, B Eddris, C Blackburn, E Richie, K Weinberg, N Manley, J Sage*, P Viatour. Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med, 2013. *, corresponding author.

K Jameson*, PK Mazur*, A Zehnder, J Zhang, B Zanegar, J Sage, P Khavari. IQGAP1 scaffold-kinase interaction blockade selectively targets Ras-MAP kinase-driven tumors. Nature Medicine, 2013. *, equal contribution.

J Conklin, J. Baker, J Sage. The RB family is required for the self-renewal and survival of human embryonic stem cells. Nature Communications, 2012.

J Sage. The retinoblastoma tumor suppressor gene in stem cell biology. Genes Dev, 2012.

H Chen, X Gu, Y Liu, J Wang, SE Wirt, R Bottino, H Schorle, J Sage, SK Kim. PDGF signaling controls age-dependent proliferation in pancreatic beta-cells. Nature, 2011.

KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, K Bernard, JF Conklin, A Szczepny, J Yuan, R Guo, B Ospina, J falzon, S Bennett, TJ Brown, A Markovic, WL Devereux, CA Ocasio, JK Chen, T Stearns, RK Thomas, M Dorsch, S Buonamici, DN Watkins, CD Peacock*, J Sage*. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature Medicine, 2011. *, co-corresponding authors.

P Viatour, U Ehmer, LA Saddic, C Dorrell, JB Andersen, C Lin, AF Zmoos, BE Schaffer, A Ostermeier, H Vogel, KG Sylvester, SS Thorgeirsson, M Grompe, J Sage. Notch signaling inhibits hepatocellular carcinoma upon inactivation of the RB pathway. J Exp Med, 2011.

LA Saddic, LE West, A Aslanian, JR Yates III, SM Rubin, O Gozani, J Sage. Methylation of the retinoblastoma tumor suppressor by SMYD2. Journal of Biological Chemistry. 2010.

S Wirt , AS Adler, V Gebala, JM Weimann, BE Schaffer, LA Saddic, P Viatour, H Vogel , HY Chang, A Meissner, J Sage. Cell cycle exit and terminal differentiation independent of the RB gene family during embryonic development. Journal of Cell Biology. 2010.

KV Pajcini, SY Corbel, J Sage, JH Pomerantz, HM Blau. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 2010.

DL Burkhart, SE Wirt, A Zmoos, J Sage. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genetics. 2010.

P Viatour, TC Somervaille, S Venkatasubrahmanyam, S Kogan, ME McLaughlin, IL Weissman, AJ Butte, E Passegue, J Sage. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008.

FA Dick, DW Goodrich, J Sage, NJ Dyson. Non-canonical functions of the RB protein in cancer. Nat Rev Cancer, 2018.

Last modified: May 7, 2018